RENIN-ANGIOTENSIN-ALDOSTERONE SYSYTEM And HAIR LOSS PROCESS

LLight

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That's in a kidney cell but the results they found seem interesting:

"MR expression is tightly regulated by osmotic stress. Hypertonic conditions induce expression of tonicity-responsive enhancer binding protein, an osmoregulatory transcription factor capable of binding tonicity-responsive enhancer response elements located in MR regulatory sequences. Surprisingly, hypertonicity leads to a severe reduction in MR transcript and protein levels. [...] In sharp contrast, hypotonicity causes a strong increase in MR transcript and protein levels."​

Osmotic Stress Regulates Mineralocorticoid Receptor Expression in a Novel Aldosterone-Sensitive Cortical Collecting Duct Cell Line
 

GorillaHead

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That's in a kidney cell but the results they found seem interesting:

"MR expression is tightly regulated by osmotic stress. Hypertonic conditions induce expression of tonicity-responsive enhancer binding protein, an osmoregulatory transcription factor capable of binding tonicity-responsive enhancer response elements located in MR regulatory sequences. Surprisingly, hypertonicity leads to a severe reduction in MR transcript and protein levels. [...] In sharp contrast, hypotonicity causes a strong increase in MR transcript and protein levels."​

Osmotic Stress Regulates Mineralocorticoid Receptor Expression in a Novel Aldosterone-Sensitive Cortical Collecting Duct Cell Line


So whats this mean exactly?


And what is topical licorice the answer now? For both body hair and scalp hair?
 

LLight

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So whats this mean exactly?
Less fluids -> higher osmotic "stress" & TonEBP expression (the osmoregulatory transcription factor) -> less Mineralocorticoid Receptor -> less bad effect of MR activation?

The question is whether this effect remains true for other cells than these kidney cells and whether this relation is true at physiological level of osmotic stress.
 

GorillaHead

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Less fluids -> higher osmotic "stress" & TonEBP expression (the osmoregulatory transcription factor) -> less Mineralocorticoid Receptor -> less bad effect of MR activation?

The question is whether this effect remains true for other cells than these kidney cells and whether this relation is true at physiological level of osmotic stress.
So diuretics basically
 

LLight

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So diuretics basically
Not sure it's a viable solution :):

Maybe less fluid consumption and/or fluid which will not induce hypo-osmotic situation. More salt if it doesn't induce thirst.

I wonder if the homeless-no hairloss conundrum could be linked to that. Alcohol is diuretic right? Have you ever seen a homeless person drinking plain water ;)
 
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LLight

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And thus, when they are not drinking alcohol, they may "implement" a sort of intermittent drinking pattern:
Intermittent Drinking, Oxytocin and Human Health - PubMed
"Recent research shows that the homeostatic disturbances leading to the "thirst feeling" not only activate specific substances regulating water and mineral household, but also the "trust and love" hormone oxytocin, while decreasing the production of the typical stress hormone cortisol."

"Animals drink up to satiety every time they drink, just as infants do. So infants and animals ‘‘suffer” real thirst (regulatory/physiologicalt thirst 14) based on hypernatremia, hypovolemia and/or
hyperosmolality
[15,16] and these conditions induce increased oxytocin signaling (Olszewski, 2010). Oxytocin has numerous effects on multiple physiological mechanisms and oxytocin influences behaviour significantly (see below). The mentioned up to satiety-drinking behaviour of infants every time they are breast-fed, is opposite to modern adults who drink small amounts of liquid, often numerous times every day."​
 
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ivy

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Spironolactone is a diuretic. A potassium sparing one. Still wouldn't go that way.
 

LLight

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So infants and animals ‘‘suffer” real thirst (regulatory/physiologicalt thirst 14) based on hypernatremia, hypovolemia and/or hyperosmolality [15,16] and these conditions induce increased oxytocin signaling (Olszewski, 2010).

Moreover (I don't know if it's bull****):
"Radiant skin and hair are universal indicators of good health. It was recently shown that feeding of probiotic bacteria to aged mice rapidly induced youthful vitality characterized by thick lustrous skin and hair, and enhanced reproductive fitness, not seen in untreated controls. Probiotic-treated animals displayed integrated immune and hypothalamic-pituitary outputs that were isolated mechanistically to microbe-induced anti-inflammatory interleukin-10 and neuropeptide hormone oxytocin."
Probiotic ‘glow of health’: it’s more than skin deep
 

GorillaHead

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Makes me think balding is edema. Honestly theres some research the other day that said balding scalp had characteristics of edema. Time to hop on the hawthorne berry
 
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Makes me think balding is edema. Honestly theres some research the other day that said balding scalp had characteristics of edema. Time to hop on the hawthorne berry
Interesting edema.

That correlates with my experience quite well..
 

mrchibbs

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Estrogen causes edema, and Ray says that it’s basically the first stage of energy deficiency, before the fibrosis, so yeah it’s probably involved
 

GorillaHead

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Estrogen causes edema, and Ray says that it’s basically the first stage of energy deficiency, before the fibrosis, so yeah it’s probably involved


Actually ***t edema makes hella sense cause for example I got work done on my nose and they tell u then longer the swelling the more likely their will be fibrosis.
 

GorillaHead

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Edema can be caused by protein deficiency
Protein wasting hair loss

ya but this is def not caused by protein wasting. Lol bodybuilders eat a ***t load of protein lol. This is due to blood sugar imo. And the veins in top are highly sensitive
 
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md_a

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I think the answer to hair loss is in the blood circulation which can be locally disrupted, the local vasodilators help but they probably also have side effects, instead CO2 produced on a normal metabolism maintains blood circulation in a healthy way. Ray Peat's answer below I think explains very well what happens with the blood circulation, edema, calcification, fibrosis are stages related to this process. From Kate Deering fb: Blood clots, serotonin and COVID-19

After listening to Dr. Peat's last interview on One Radio Network, I started to wonder about the affects of high serotonin in relation to the symptoms of COVID-19.

First, let's talk about serotonin.
-95% of serotonin is produced in the gut. When you are stressed, you produce MORE estrogen, cortisol AND SEROTONIN, not less. Diarrhea, nausea, vomiting, migraines, anxiety, and sweating are all related to excess serotonin.
-Serotonin is NOT the happy hormone you have been lead to believe. Increasing serotonin CAN increase gut motility, this alone can make someone "feel" better.
-Estrogen can promote serotonin. Serotonin can promote estrogen. Both can promote cortisol.
-Serotonin can activate all the system of the body that promote cortisol--pituitary, adrenals, and brain.
-Starvation and diabetes can increase serotonin in the brain
-On the microscopic level, stress, serotonin, and cortisol cause changes in cell structure,
-Learned helplessness and serotonin are strongly correlated.

When the gut is irritated by stress (bacteria, endotoxin, fibrous foods, chemicals, drugs, alcohol, crappy thinking, and/or corona viruses), serotonin production increases. The lungs are the main detoxifier of serotonin. When the lungs are damaged (which can happen with age, pollution, respiratory illness, or even a heater that is run all day long), detoxification decreases. When this happens, serotonin can build up in the blood, leading to serotonin toxicity or serotonin syndrome. One common symptom of serotonin syndrome is blood clotting...

Here are the other symptoms of excess serotonin:

Early stages
-Diarrhea
-Nausea
-Sweating
-Anxiety
-Fever

Serotonin syndrome complications include:

-Seizures
-Decreased Oxygen in the blood--lower O2 saturation
-Small blood clots in your bloodstream
-Muscle damage called rhabdomyolysis
-High acid levels called metabolic acidosis
-Kidney failure
-Elevated D-Dimer
-Fluid in the lungs, called acute respiratory distress syndrome (ARDS)
-Cardiovascular disease

Hmmm, these complications look VERY familiar.
Hint:CV-19

Essentially, the more stress you place upon the body, the more serotonin will be produced. If you add in lung issues, you may have a BIG problem. Serotonin syndrome can also occur from medications that increase serotonin levels, these include most antidepressants (SSRI's, SNRI's, MAOI's) pain meds. (opioids), and recreational drugs (cocaine, MDMA) plus the cough medicine dextromethorphan.

I asked Dr. Peat about the serotonin-blood clot-CV connection: here is his response:

"The coronas, like polio, have a strong tendency to grow on the intestine (also heart, lungs, blood vessels), and the (or any) inflammation in the bowel releases large amounts of serotonin, histamine, and endotoxin into the blood, adding to any lung problem from direct infection.

The angiotensin system increases estrogen, prostaglandins, nitric oxide and other inflammation mediators, so many anti inflammatory things help with this virus. Before big stringy, plugging clots form, the thin fibrin film that always coats red blood cells and the inside of capillaries begins getting thicker as the equilibrium between forming and dissolving the fibrin film shifts toward faster forming, and oxygenation of tissues lags behind deoxygenation of blood cells.

Lactic acid formation in response to hypoxia and stress signals adds to the inflammation of the lungs, causing them to take up water even if they aren’t infected."

-Dr. Ray Peat
 

Vinny

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Makes me think balding is edema. Honestly theres some research the other day that said balding scalp had characteristics of edema. Time to hop on the hawthorne berry
Why the hawthorne berry? What does it do?
 

Ableton

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Diuretics are prescribed all the time, if they had a powerful effect I think we would know about it
 

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