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Relative Testosterone Deficiency And Hypogonadotropism May Lead To Zinc Deficiency


Sep 25, 2017
Zinc deficiency tends to cause few androgens but according to this study it is possible that androgen deficiency causes zinc deficiency. Zinc increases when methyltestosterone is given, especially in boys with growth delay. And zinc level in boys beyond stage 3 of genital development are higher than in stage 1. :emoji_honey_pot::emoji_dart::emoji_bowling:
Zinc nutritional status, androgens, and growth retardation.
Castro-Magana M, Collipp PJ, Chen SY, Cheruvanky T, Maddaiah VT.
Zinc levels were measured in hair and serum of boys with constitutional growth delay and familial short status and in several boys before and after oral administration of methyltestosterone. These results show the following: (1) zinc levels in boys beyond stage 3 of genital development are significantly higher than in stage 1 and 2; (2) there is a linear relationship between zinc levels and serum testosterone concentration (up to 250 ng/dL); and (3) methyltestosterone administration raised the zinc concentration in serum and hair, especially in boys with constitutional growth delay. Therefore, increased endogenous production or exogenous supply of testosterone are associated with increased zinc levels. We speculate that the relative testosterone deficiency and hypogonadotropism seen in constitutional growth delay may result in decreased zinc levels, which in turn could cause a further delay in the appearance of secondary sexual characteristics and greater growth retardation.
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