Relationship Between The Blood Concentration Of Several Metals &Endocrine Disorders Of Aging Males


Jan 6, 2015
Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with m... - PubMed - NCBI


Beyond 30 years of age, men experience a decline in the production of testosterone, yet only a few develop late-onset hypogonadism. This study was designed to determine the relationship between blood concentrations of metals, macro- and micronutrients and age-related testosterone deficiency and associated hormonal changes in aging men. The research involved 313 men aged 50-75 years. We used ELISA to determine the concentrations of total testosterone (TT), free testosterone (FT), estradiol (E2), dehydroepiandrosterone sulfate (DHEAS) and sex hormone-binding globulin (SHBG). We calculated free androgen index (FAI). With the use of emission spectrometry in inductively coupled argon plasma, we determined the whole-blood concentrations of lead (Pb), cadmium (Cd), mercury (Hg), arsenic (As) and tungsten (W), as well as serum concentrations of magnesium (Mg), iron (Fe), calcium (Ca), copper (Cu), zinc (Zn), selenium (Se), chromium (Cr), manganese (Mn) and molybdenum (Mo). The study showed no relationship between TT and FT and the concentrations of metals. Men with TT deficiency had significantly lower concentrations of Mg and Fe and increased Mn. Men with FT deficiency had higher W and Cr levels and lower Fe. Assessing the correlation between the concentrations of hormones, SHBG and FAI, and the concentration of metals and macro- and microelements in the blood of the men, we found positive correlations between the concentrations of TT-Mg, TT-Fe, TT-Mo, FT-Fe, E2-As, SHBG-Mn, FAI-W, FAI-As, FAI-Zn and FAI-Ca, and negative correlations between the concentrations of TT-Mn, FT-Cd, FT-Cr, E2-Hg, E2-Cr, SHBG-W, SHBG-As, SHBG-Zn, SHBG-Ca, FAI-Pb and FAI-Mn. Positive correlations between As and E2 and between As and FAI may suggest a lack of association between this metal and hypogonadism in people not exposed to excess As levels. Our research indicates a positive relationship between the concentrations of Mg, Fe and Zn and endocrine system in aging men, in contrast to Mn and Cr. Toxic metals (Cd, Pb) seemed to negatively affect the level of bioavailable testosterone. In persons not exposed to As, As does not contribute late-onset hypogonadism. Heavy metals (Pb, Cd, Hg and W) may contribute to a lower concentration of DHEAS. The role of W in men with LOH was found to be ambiguous, as on the one hand its concentration was higher in men with FT deficiency, and on the other hand it positively correlated with FAI, which in turn indirectly indicates testosterone availability. Copper and selenium do not seem to play any significant role in the occurrence of TT deficiency in aging men.
Similar threads
Thread starter Title Forum Replies Date
bzmazu Relationship Between Blood Clotting And Covid-19 Viruses, Parasites, Fungus, Vaccines 6
goodandevil Relationship Between Urine Ph, Blood Ph, Diet Articles & Scientific Studies 3
Gunnar Relationship Between Aspirin And Vitamin K Supplements, Pharmaceutical Drugs 1
S A Direct Relationship Between PUFA And Allergies Polyunsaturated Fats, Seed Oils 2
charlie A Statistically Strong Relationship Has Been Found Between The MMR Vaccine & Autism Vaccines 2
Mito Inverse Log-Linear Relationship Between TSH Free T4 Thyroid and Hormones 1
J Is There A Relationship Between CO2 And Estrogen? Health 6
J Can Someone Explain The Relationship Between Thyroid Function And Darkness? Thyroid and Hormones 2
L No Relationship Between Dietary Linoleic Acid Intake And Tissue Arachidonic Acid Content Scientific Studies 23
P The Relationship Between Serum Level Of Manganese And Severity Of Coronary Atherosclerosis Articles & Scientific Studies 18
S Inverse Relationship Between Lifelong Premature Ejaculation And Obesity Articles & Scientific Studies 3
milk_lover The Relationship between Prolactin and Dietary Calcium Diet 22
B A Reappraisal Of The Quantitative Relationship Between Sugar Intake And Dental Caries: The Need For Articles & Scientific Studies 0
J The relationship between dose of vitamin E and suppression o Articles & Scientific Studies 0
burtlancast The Relationship Of Fluoride Exposure, The Pineal Gland And Sleep In Adolescents Insomnia, Sleep Issues 20
nigma Gravity As A Stressor, And Its Relationship To Sleep And Consciousness Mind, Sleep, Stress 13
L 2 Recent Studies On Cortisol/androgen Relationship Scientific Studies 0
L Basal Testosterone's Relationship With Dictator Game Decision-making Depends On Cortisol Reactivity Scientific Studies 0
S Vitamin A And Microbiome Relationship Digestion, Gut Flora 3
S Hedonistic Relationship To Food And Bad Dietary Recommendations By Governing Bodies Society 18
Gadsie Should I Stay In A Non-peat Relationship Ask For Help or Advice 48
vulture Thyroid - Pituitary - Gonads Relationship Study Scientific Studies 23
J T3s Relationship To Liver Glycogen Story Thyroid and Hormones 9
J Caffeine & Thyroids Relationship To Satiety Synthetic Thyroid 46
ShirtTieFitness Sauna Use Has An Inverse Relationship With Fatal Cardiovascular And All-Cause Mortality Events Scientific Studies 1
bzmazu Relationship Of A To D From Sunshine Only Supplements, Pharmaceutical Drugs 5
G The Functional Relationship Mental Issues 0
P Relationship Phospholipids To Omega Fatty Acids? Supplements 8
burtlancast Hot Flashes, Night Sweats, The Relationship To Stress, KMUD Herb Doctors , 2012 Audio Interview Transcripts 9
burtlancast Project 8 (NON FULL): William Blake And Art's Relationship To Science, Politics And Science, 2014 Interview Transcript Projects 10
LucyL Vaccines And Autism, The Selye Relationship? Vaccines 15
Mito No correlation between lockdowns and death rates? Miscellaneous Health Discussions 3
ScurveDream Differences between begging and working -- a comprehensive outlook of livelihood. Miscellaneous 1
I Study Showing Mitochondria moving between cells Scientific Studies 0
S People in Quebec, Canada, are not allowed to leave home between 8 p.m. 5 a.m. Political Talk, Alternative World Theories 0
Mr Joe What's the link between CO2, Methylene blue, ATP and Electricity (Ether) ? Ask For Help or Advice 2
T Is it possable for people to react differently between Benzodiazapines? Supplements, Pharmaceutical Drugs 0
Hugh Johnson French professor who found links between the Pasteur institute and covid19 forced into a mental asylum. Society 4
Mauritio Autism Study Suggests Connection Between Repetitive Behaviors And Gut Problems Scientific Studies 9
Lokzo It’s MORe Exciting Than Mu: Crosstalk Between Mu Opioid Receptors And Glutamatergic Transmission Scientific Studies 0
H Link Between Alzheimer's Disease And Gut Microbiota Is Confirmed Alzheimer's 1
Lewis Acid Lucid Dreaming: Increased Connectivity Between Frontopolar Cortex & Temporoparietal Areas Mind, Sleep, Stress 3
Tristan Loscha Metabolomics Study Reveals Differences Between Diabetic And Non‐diabetic Patients With Cataract Eyes, Ears, Nose and Headaches/Migraines 0
L Association Between High Serum Total Cortisol Concentrations And Mortality From COVID-19 Scientific Studies 0
Hgreen56 How To See The Differents Between Full Belly And Bloat? Diet 0
U How To Lengthen Time Between Cycles? Female Issues 4
Amber Connection Between Liver Dysfunction & Hypothyroidism Thyroid and Hormones 41
md_a There Is An Extremely Important Connection Between ACE-inhibitor Medication For Hypertension And The Scientific Studies 2
md_a Similar Patterns Of Pulmonary Disease Between HAPE And COVID-19 Scientific Studies 6
Atma Return To The Brain Of Eden: Restoring The Connection Between Neurochemistry And Consciousness The Ray Peat Forum Lounge 5

Similar threads