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- Aug 24, 2017
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Quite a few enzymes and pathways can produce ROS, for example, MAO, xanthine oxidase, NOX, ETC, etc., although the ETC is by far the largest contributor. ROS serves a purpose in that it signals mitochondrial biogenesis, fission, autophagy, etc. Buring fructose and saturated fat can create more ROS than burning other fuels which can be beneficial by inducing UCP, signaling mitochondrial biogenesis and killing cancer cells and so on.Hey Hans, speaking of ROS, wanted your opinion. We see sometimes read the benefits of it such as saturated fat+sugar in controlling blood sugar. When and how can we conclude ROS is beneficial or harmful?
However, the risk comes in when, for example, one or more of the complexes in the ETC doesn't work optimally anymore. Then a lot more ROS is created, and in the presence of low anti-oxidants enzymes and substrates, such as SOD, CAT, glutathione, vitamin E, C, etc., then there will be an excess of ROS and oxidative stress. Too much ROS inhibits fusion and promotes fission and this leads to an overwhelmed autophagy and an accumulation of smaller less efficient and even toxic mitochondria.
So my approach would be to make sure my ETC is working optimally and my anti-oxidant enzymes are optimized at all times by eating a nutritious diet which provides all my vitamins and minerals as well as minimizing stress, toxins, EMF, pollution, heavy metals, pharma drugs, low quality water, etc.