Ray Peat Email Advice Depository

Discussion in 'Email Advice' started by charlie, Jan 14, 2013.

  1. yerrag

    yerrag Member

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    I failed to include this earlier:
    *Osteoporosis drug strontium ranelate (Protelos) no longer available after August 31
    May 2017
    The osteoporosis medication strontium ranelate (Protelos) will no longer be available in the UK after August following a decision by its manufacturers Servier to cease marketing and supply of the drug treatment.
    The decision, the manufacturers says, has been taken because of commercial reasons based on the drug having limited uses and being prescribed to - and used by - very few people.
    This decision follows safety concerns about the drug connected to cardiovascular risks which have led to its limited use and a continuous decrease in those being treated with it. Strontium ranelate will no longer be available anywhere in the world from August 2017.
    Protelos was licensed for treatment of severe osteoporosis in postmenopausal women and adult men at high risk of fracture.

    Sarah Leyland, Osteoporosis Nurse Consultant at the National Osteoporosis Society, said anyone currently taking this treatment is advised to talk to their GP.
     
  2. DaveFoster

    DaveFoster Member

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    Do you think that, if someone gained some benefit from more T3 in their thyroid ratio, could that same benefit be mimicked entirely with coffee (sugared of course)? In other words, would some amount of coffee combined with a 1 to 4 ratio of T3 to T4 be equivalent to a 1 to 3 ratio without any coffee, or would the effects differ?

    Dr. Peat: "Sugar and coffee can sometimes reduce stress enough to improve T3 level, but it’s hard to predict."​
     
  3. jamies33

    jamies33 Member

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    Question: As I understand it, the main purpose of high dietary calcium is to keep Ca:P balanced, so as to minimize PTH. Vitamin D also brings down PTH. Could high vitamin D surrogate for high calcium intake?
    Dr. Peat: "Both calcium and vitamin D contribute to lowering PTH. Thyroid hormone and sugar help, too. Even baking soda can help."

    Question: Is there an optimal daily magnesium target you recommend? An optimal Ca:Mg balance? In Nutrition for Women, you recommend 1200mg.
    Dr. Peat: "Thyroid function is the crucial thing for magnesium retention, much more important than the ratio and quantity."
     
  4. theLaw

    theLaw Member

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    Q: Do you know of any negative health effects of drinking a full gallon of high-quality Orange Juice + a full gallon of low-fat milk per day provided enough salt is taken with it?

    Also, did you notice any issues personally from drinking large amounts of those liquids over the years?

    A:
    In hot weather I’ve used that amount, and have never noticed harmful effects. I usually had some salty cheese or other foods with it.
     
  5. Dan Wich

    Dan Wich Member

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    Some e-mails forwarded to me:

    On thyroid in alcohol and testosterone replacement:
    On post New-Deal America:
    On Selye:
    See Jahed's post for the context on this one:
     
  6. Peatit

    Peatit Member

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    Q: Would it be clever to dissolve pregnenolone in oil or vitamin E to increase its tissues availability by bypassing the liver?

    A: I haven’t noticed much difference, I think because it dissolves quickly in the bile with fats in foods.
     
  7. theLaw

    theLaw Member

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    Q: If someone needed a large number of calories to keep stress low (like 5000), what foods would you suggest while they transition to a healthier diet as liquids might pose a problem for those who are hypothyroid?

    A: Magnesium and calcium-rich foods, cooked greens, cheese, mushrooms, help with stress.
     
  8. jahed

    jahed New Member

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    [QUOTE="Dan Wich, post: 386792, member: 446"
    On why he talks more about biology than politics:[/QUOTE]

    The question was actually more about what can be done in the face of learned helplessness from e.g. capitalism, racism, neoliberalism, etc. my full original question is below, and was a bit different than the biology / politics divide:

    Q: I've been reading Frantz Fanon lately, the psychiatrist and revolutionary socialist. He speaks at length about mental disorders that the colonized experienced for the last ~400 years. He delves deeply into both the trauma experienced by colonizers and the colonized, and I think that even if you live in a western society like the US, you are still internally colonized by capital, with all of the concomitant responses, physiological and otherwise. Unless you're rich.

    I wanted to ask you - how do you deal with what can be I guess learned helplessness via just, understanding our environment, the social forces shaping it, and the at times, nihilistic outlooks?

    For instance, I think it's clear that mitochondria are at the center of the organism's response to stress, in both acute and chronic cases. They modulate the organism's response to stress as you've pointed out many times, but I think it's important to emphasize the perception of stress is also experienced, internalized, and reacted to. This much is absolutely true, at least in rats. What is this like over time?

    Is it possible for us to address these issues with nutritional, supplemental, and chemical means alone, or do we need to organize ourselves, our minds, and our actions in such a way ultimately that leads to better possibilities for us? If our perception of our condition is dark, and this perception and experience is true, as Lenin said, what is to be done?
     
  9. Ray on wisdom teeth and pericoronitis:
    "Mine had been impacted for about 15 years, and within 2 or 3 weeks of taking a small amount of DHEA they erupted properly.
    Antibiotic and topical antiseptic are commonly used."
     
  10. mimmo123

    mimmo123 Member

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    Me: Topically I been adding Dhea and Progesterone on the mole for about a week now but havent seen any change.
    How long did you do it to see a change?

    RP: I’ve never applied anything directly to a mole, because of the danger of causing irritation that could cause cancerization. When I have put progesterone or DHEA (dissolved in vitamin E) on the skin about an inch away from a mole, I have seen changes the next day, with steady shrinking during a week or 10 days. Sometimes I have just increased my dose of T3, to keep my daytime temperature at least normal, and it increase my resting pulse rate to about 95 beats per minute. I think I have accelerated the dissappearance of some moles by soaking in a bath containing epsom salts, baking soda, and salt.
     
  11. Beastmode

    Beastmode Member

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    ME:
    Do you believe their is. or will be, a time where stem cell injections can be a viable option?

    The anecdotal evidence I've read or heard of so far is that placenta stem cells are the most effective have helped a lot of people.

    Anything worth reading on this subject in your opinion that helps better understand your view point?

    RAY:
    Urine and menstrual blood are good sources of stem cells, but I think their main value is in learning the principles of regulating them. As a practical method for health maintenance, I think learning how to activate and regulate the existing system of stem cells is the correct approach.
     
  12. Ray on varicocele:

    "I think they develop because of an excess of cortisol relative to DHEA and pregnenolone. That imbalance is likely to occur with low protein intake, low thyroid, and low vitamins D and A."
     
  13. Dan Wich

    Dan Wich Member

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    More e-mails forwarded to me:

    On having estradiol levels under the lower end of the reference range:
    On hiatal hernia treatments:
     
  14. HDD

    HDD Member

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    On adjusting to high altitude-

    If a person’s thyroid function is borderline, adaptation to altitude is harder. It’s always best to rest for the first couple of days at altitude. Diamox, Coke, sugar, aspirin, and maybe baking soda can help. It’s good to make sure that it’s CO2 in the tanks, other, harmful gases are sometimes sold for similar uses.

    Aspirin for prophylaxis against headache at high altitudes: randomised ...
    Aspirin for prophylaxis against headache at high altitudes: randomised, double blind, placebo controlled trial
    by M Burtscher - ‎1998 - ‎Cited by 96 - ‎Related articles
    At altitudes of 3000-5000 m about 20-50% of skiers and mountaineers experience headache, the main symptom of acute mountain sickness. ... The use of drugs to prevent and treat headaches at high altitudes is therefore widespread, aspirin being one of the most commonly taken.

    ASPIRIN CAN HELP PREVENT HIGH-ALTITUDE SYMPTOMS - The ...
    https://www.washingtonpost.com/.../aspirin...altitude.../3714d41d-a070-46a8-96a0-0716...
    Jun 16, 1998 - ASPIRIN CAN HELP PREVENT HIGH-ALTITUDE SYMPTOMS. ... Seven people who received the placebo developed mild to severe headaches, but only one aspirin recipient reported headache -- a significant difference. High-altitude headache tends to occur as the oxygen level in the blood drops.

    Eur J Appl Physiol. 2018; 118(3): 607–615.
    Sodium bicarbonate supplementation improves severe-intensity intermittent exercise under moderate acute hypoxic conditions
    Sanjoy K. Deb, Lewis A. Gough, S. Andy Sparks, and Lars R. McNaughton
    Acute moderate hypoxic exposure can substantially impair exercise performance, which occurs with a concurrent exacerbated rise in hydrogen cation (H+) production. The purpose of this study was therefore, to alleviate this acidic stress through sodium bicarbonate (NaHCO3) supplementation and determine the corresponding effects on severe-intensity intermittent exercise performance. Eleven recreationally active individuals participated in this randomised, double-blind, crossover study performed under acute normobaric hypoxic conditions (FiO2% = 14.5%). Pre-experimental trials involved the determination of time to attain peak bicarbonate anion concentrations ([HCO3−]) following NaHCO3 ingestion. The intermittent exercise tests involved repeated 60-s work in their severe-intensity domain and 30-s recovery at 20 W to exhaustion. Participants ingested either 0.3 g kg bm−1 of NaHCO3 or a matched placebo of 0.21 g kg bm−1 of sodium chloride prior to exercise. Exercise tolerance (+ 110.9 ± 100.6 s; 95% CI 43.3–178 s; g = 1.0) and work performed in the severe-intensity domain (+ 5.8 ± 6.6 kJ; 95% CI 1.3–9.9 kJ; g = 0.8) were enhanced with NaHCO3supplementation. Furthermore, a larger post-exercise blood lactate concentration was reported in the experimental group (+ 4 ± 2.4 mmol l−1; 95% CI 2.2–5.9; g = 1.8), while blood [HCO3−] and pH remained elevated in the NaHCO3 condition throughout experimentation. In conclusion, this study reported a positive effect of NaHCO3 under acute moderate hypoxic conditions during intermittent exercise and therefore, may offer an ergogenic strategy to mitigate hypoxic induced declines in exercise performance.
     
  15. Beastmode

    Beastmode Member

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    ME:
    Does the same rule apply for a female toddler in regards to it being harder for T4 to convert to T3 via liver due to more estrogen than a toddler boy?

    Our daughter takes T3/T4 (equal to 1/16th of cynoplus per day) and we're wondering if the T3/T4 should be more of a night usage due to T4's effect on TSH at night and possibly T3 only during the day.

    We estimate based on the 1/16th of cynoplus, around 1 mcg of a cytomel would equate to what she was getting from the cynoplus (during the day.)

    Is our thinking correct based on your experience?

    p.s- Since starting her thyroid therapy, she stood for the first time in about week into the therapy and walked solo for the first time after 44 days (12 steps.)

    PEAT:
    I don’t know that there’s a gender difference at that age; the T3 component in the combination is likely to improve her liver function so that the T4 is effective. Recently someone told me that their non-walking kid had her first bowl of ice cream and almost immediately started walking.
     
  16. milk_lover

    milk_lover Member

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    Me:
    "What is your opinion on using diluted baking soda on hair instead of commercial shampoos? Would it be good for the hair health?"

    Peat:
    "It’s what I normally use."

    Me:
    "Do you have a specific ratio for baking soda to water in order to minimize the alkalizing effect of the solution and get the best results?"

    Peat:
    "No, it takes very little to clean the hair."
    ----------------------------------------------------------
    Me:

    "I can’t seem to tolerate aspirin as I think it gives me puffy nipples and overall body water retention for some reason and I know how you think highly of it. Can niacinamide substitute for aspirin in opposing estrogen and other beneficial effects?

    I heard niacinamide could reduce methylfolate because it intervenes in the metabolism of methionine and methylation?"

    Peat:
    "What about your diet and temperature and heart rate? Have you had blood tests for hormones, including TSH, vitamin D, cortisol?"

    Me:
    "My diet is mostly lamb, beef, sometimes chicken, liver and seafood every two weeks, coke, white rice, goat milk, coffee, and milk chocolate. I supplement with glycine, niacinamide, magnesium, vitamin D3, vitamin K2, little progesterone and little DHEA, and sometimes vitamin E. That’s almost my diet. I try to avoid PUFA, wheat, soy, legumes, and uncooked vegetables as much as I can. Sometimes I hide under the blanket at night to increase my CO2. I have an LED red light device that’s mostly 670nm wave length but I don’t use it much because I expose myself to the sun almost daily. I would say my temperature is alright as I don’t feel cold hands and feet. My heart rate as of right now is about 80 bpm. I don’t have any tests done on me because I am doing my military service now.
    Also I take about 1.5 grams of fine activated charcoal three times a week to deal with endotoxin."

    Peat:
    "That diet might be lacking calcium relative to phosphate."

    Me:
    "I thought the goat milk would be enough. I drink about 1 liter of it. I am thinking of making my own egg shell powder (boil some egg shells to kill bacteria, heat it in the oven to reduce moister, and then use a coffee grinder to grind it finely. I hope that helps in increasing the Ca/P ratio."

    Peat:
    "Yes, it’s a good calcium source, almost zero phosphate."
    ----------------------------------------------------------
    Me:

    "What brand of aspirin do you recommend/use? Is Bayer 100 mg good?"

    Peat:
    "I use plain crystals of aspirin, USP. I think Bayer is o.k., though I don’t know what excipients they use."
    ----------------------------------------------------------
    Me:

    "I searched online and I found the ratio Ca/P of goat milk to be relatively lower than that of cow milk and camel milk. Do you still think it’s good to consume goat milk if camel and cow milk are widely available?"

    Peat:
    "I think the ratio is still good."
    ----------------------------------------------------------
    Me:

    "I’ve read online that you use the drip coffee method (paper filter) to prepare your coffee. I am currently using the French press method with metal filter. I see quite a bit of oil layer on my black coffee. Do you see any problem with this kind of coffee brewing? "

    Peat:
    "The temperature is important, the oils deteriorate quickly at boiling temperature."
    ----------------------------------------------------------
    Me:

    "I have three normal wisdom teeth. The one in the bottom left side Is inflamed and you can tell it’s trying to emerge but the gum is not letting it. When I chew solid food, I think the top left side wisdom tooth is grinding on the gum surrounding the incomplete wisdom tooth and thus I feel sharp pain and inflammation. What do you think will help solve this issue? Should I extract it? Or wait until it’s fully emerged?"

    Peat:
    "When I first tried using DHEA (about 5 mg/day) my lower wisdom teeth quickly erupted and moved into position. I think chronically slightly low thyroid function with low vitamin D is usually responsible for delayed wisdom tooth eruption."

    Me:
    "I’ve noticed also when I take charcoal, the inflammation gets worse in the wisdom tooth. So maybe there is a bacteria infection or something. I have tetracycline prescribed to me by my dentist and I am thinking of experimenting with it in the next couple of days and see how I feel. I also forgot to mention I supplement with a lot of K2 and magnesium while not drinking probably enough milk (about a liter of goat milk). Maybe that could be lowering my calcium levels too much."

    Peat:
    "Irritation in the intestine often makes a tooth infection worse, so avoiding supplements while using the antibiotic is likely to help."
    ----------------------------------------------------------
    Me:

    "Lately, I have been drinking a lot of guava juice instead of OJ and I like the taste of it. I just place the whole fruit in the mixer and I add milk, sugar, and ice. Do you think the seeds in guava would be problematic?"

    Peat:
    "If they are broken by the blender, I think it would be good to strain them out. When the seeds are swallowed whole, they pass through without harmful effects."
    ----------------------------------------------------------
    Me:

    "I apply D3 on my shoulders and chest. Sometimes, I feel cold when I apply it. I read online that vitamin D can sometimes cause hypothermia. What is your opinion about that?"

    Peat:
    "I don’t think it can cause hypothermia. Have you checked your temperature?"

    Me:
    "I always have the AC on and the cold air hits my feet. I take vitamin D dissolved in SFA esters and ethanol and my feet start to feel cold all of the sudden, so I have to turn the AC off. When I take vitamin D dissolved in MCT oil, I don’t feel that much cold. So I don’t know what’s going on here."
    ----------------------------------------------------------
    Me:

    "I recently read a study that claims vitamin D3 increases TPH2, which means vitamin D3 can increase brain serotonin. I read natural progesterone can reduce TPH2, but I don’t want to supplement with progesterone because it has some anti-androgenic effects on me. What are some tools I can take to reduce TPH2 when I supplement with vitamin D3?"

    Peat:
    "I think it’s calcitriol that does that, and a vitamin D and calcium deficiency or phosphate excess increases calcitriol. Serotonin tends to cause bone loss, increasing parathyroid hormone."
    ----------------------------------------------------------
    Me:

    "The other day I had an argument with my cousin who studies biology at a university. He’s claiming we came from apes. I look at apes and I see resemblance in the way they walk and use their thumbs to grab things, but other than that, their faces are nothing like our faces. Do you agree with Darwin that we came from apes?"

    Peat:
    He didn't answer that
     
  17. tca300

    tca300 Member

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    Me: Do you think its possible that if someone has been chronically eating foods they are allergic or sensitive to that the body might defensively lower thyroid function? Thanks!

    Ray
    : The stress hormones produced by allergy cause the liver to convert thyroxine to reverse T3, lowering thyroid function, apparently in a kind of defensive semi-hibernation.
     
  18. damngoodcoffee

    damngoodcoffee Member

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    Me:
    "Do you think the original Hebrews are black?"

    Ray:
    "I think the Ethiopian and North African Jews are more directly connected than the eastern European and central Asian groups."
     
  19. Beastmode

    Beastmode Member

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    This is what Ray had to say about breastfeeding mothers getting vaccines.

    Ray:
    Substances in a vaccine are able to trigger a reaction in a nursing baby who is allergic to that substance. Any immune reaction affects the mother’s physiology, and vaccination can affect the quality and quantity of the milk. Commercial dairies are interested in this because it can affect their profits, but the medical business prefers not to investigate the subject, because it could affect their profits.

    Vet Record, 1997, Vol. 140(8), p. 196-9.
    Effect on milk production of vaccination with a bovine herpesvirus 1 gene-deleted vaccine
    J. C. Bosch, DVM, K. Frankena, MScAg, PhD and J. T. van Oirschot, DVM, PhD
    A field trial was conducted to determine the effect of vaccination with an inactivated bovine herpesvirus 1 (BHV1) gE-negative marker vaccine on the milk production of dairy cows. The daily milk yield of 455 cows in six herds was measured electronically from six days before vaccination until 14 days after vaccination. The treatment consisted of two injections with either vaccine or placebo, both at an interval of four weeks. There was a small, but significant (P<0.05), decrease of about 1.4 litres per cow in milk production after a double vaccination, the negative effect being slightly greater after the second vaccination.

    Vet Ther. 2008 Summer;9(2):141-6.
    Comparison of postvaccinal milk drop in dairy cattle vaccinated with one of two
    different commercial vaccines.
    Bergeron R(1), Elsener J.
    (1)Clinique Vétérinaire Bon Conseil, Notre-Dame-Du-Bon-Conseil, Quebec, Canada.
    Several veterinarians and dairy producers elect to vaccinate dairy herds with
    killed combination products in the fall or spring. Postvaccinal milk drop has
    been reported following the use of some killed vaccines, making it important to
    identify vaccines that can cause milk drop and evaluate the magnitude of
    postvaccinal milk drop. This study compared the pre- and postvaccinal milk
    production levels of dairy cows vaccinated with two commercial vaccines or
    injected with a saline placebo. Dairy cows receiving vaccine C (Cattlemaster Gold
    FP5; Pfizer Animal Health, Montreal, Canada) experienced a statistically
    significant difference in mean postvaccinal milk drop (-1.83 kg/cow/day) compared
    with cows receiving vaccine T (Triangle 4+Type 2 BVD, Wyeth Animal Health,
    Guelph, Ontario, Canada; -0.63 kg/cow/day) or saline (-0.02 kg/cow/day).

    J Am Vet Med Assoc. 1996 Oct 1;209(7):1291-3.
    Effect of vaccination with an Escherichia coli bacterin-toxoid on milk production
    in dairy cattle.
    Musser JM(1), Anderson KL.
    (1)Department of Food Animal and Equine Medicine, College of Veterinary Medicine,
    North Carolina State University, Raleigh 27606, USA.
    OBJECTIVE: To determine whether vaccination of lactating cattle with an
    Escherichia coli J5 bacterin-toxoid would produce a significant short-term change
    in milk production.
    DESIGN: Randomized, controlled clinical trial.
    ANIMALS: 84 healthy, lactating cows (42 Holsteins and 42 Jerseys).
    PROCEDURE: Control and vaccinated cows were paired on the basis of breed, days in
    milk, daily milk production 1 week prior to vaccination, and parity. One cow in
    each pair was inoculated IM with a commercially available bacterin-toxoid
    according to label directions; the other cow was given saline solution. Cows were
    milked twice daily for 5 days before and 5 days after inoculation. Milk
    production was compared by ANCOVA.
    RESULTS: Vaccinated cows produced significantly less milk than did control cows
    at the second and third milkings after inoculation. At these milkings, milk
    production in vaccinated cows was approximately 7% less than that of controls.
    CLINICAL IMPLICATIONS: Vaccination of lactating cattle with an E coli J5
    bacterin-toxoid may cause a significant short-term decrease in milk production.

    Tijdschr Diergeneeskd. 2001 Mar 15;126(6):173-80.
    [Analysis of symptoms associated with bovine herpesvirus 1 vaccination].
    [Article in Dutch]
    van Wuijckhuise L(1), Frankena K, van Oijen MA, Meijer L.
    (1)Gezondheidsdienst voor Dieren, Arnsbergstraat 7, 7418 EZ Deventer.
    1.v.wuyckhuise@gdvdieren.ml
    Between 1 May 1998 and 22 February 1999, it was compulsory for Dutch cattle
    farmers to take measures against bovine herpesvirus 1 (BHV1). Cattle on farms
    that were not certified as infectious bovine rhinotracheitis (IBR)-free had to be
    vaccinated twice a year. During the vaccination programme, both farmers and
    veterinarians reported side-effects of the vaccine. These reports were collected
    by the Stichting IBR/BVD Schade (SIS; Foundation for IBR/BVD Damage) in order to
    draw up a damage report. In 1999 in total 6977 cattle farmers lodged complaints
    which they considered to be related to the vaccination against BHV1. On these
    farms, 15,150 herd vaccinations had been performed, 10,269 of which were
    associated with one or more symptoms. During the compulsory vaccination period,
    13% of the herd vaccinations led to symptoms and complaints. In March 1999, a
    number of vaccine batches were found to be contaminated with bovine virus
    diarrhoea (BVD) virus. For the purposes of this analysis, a 'known contaminated'
    herd vaccination was defined as one in which at least one 'known contaminated'
    batch or lot of vaccine was used. In total, 987 of 1007 herds vaccinated with
    'known contaminated' vaccines developed one or more symptoms compatible with
    acute BVD. There were no commonly seen combinations of symptoms. For this reason,
    and because the start and end dates were not reported for 55% of the symptoms, it
    was not possible to detect a symptom pattern. Therefore there were no 'suspect'
    batches of vaccine which, although not contaminated with BVD virus, gave rise to
    symptoms. The number of BVD symptoms was determined for those herds with
    vaccination-related symptoms. There was no difference in the distribution
    frequency between batch numbers or between 'known contaminated' batches and
    'non-suspect' batches. The farmers' definition of chronic wasting was used in
    this investigation, with the inevitable large differences in definition. The
    symptom chronic 'wasting' was reported for 3209 of the 10,269 herds with
    vaccination-related symptoms. On 161 farms (164 herd vaccinations) 'chronic
    wasting' accounted for more than 20% of the symptoms. As expected, other symptoms
    were reported in addition to wasting. The symptom 'chronic wasting' was reported
    more often on forms where a 'known contaminated' vaccine was used. Inactivated
    vaccine was used for 154 herd vaccinations. In 34 cases, one or more symptoms of
    acute BVD were reported. The frequency was the same as that for live vaccines.
    The frequency of reported symptoms tended to be lower with the inactivated
    vaccine. On the basis of the SIS data, no relationship was found between vaccine
    batch and reported symptoms. This may be because (i) the classification of a
    vaccine as 'known contaminated', 'non-suspect', and 'not known' may not have been
    in keeping with the real status of the vaccine, (ii) farmers may have reported
    symptoms selectively, and (iii) there is no relationship with vaccination against
    BHV1.

    Tijdschr Diergeneeskd. 2001 Mar 15;126(6):198-207.
    [Management and herd performance of dairy herds with and without chronic wasting
    disease].
    [Article in Dutch]
    Bartels CJ(1), Barkema HW, Beiboer ML, Bouma A, Stegeman JA.
    (1)Gezondheidsdienst voor Dieren, Postbus 361, 9200 AJ Drachten.
    c.bartels@gdvdieren.nl
    'Chronic wasting' in cattle acquired a special meaning in the Netherlands in
    1999. It was used to define animal health problems that were thought to be
    associated with the use of bovine herpesvirus 1 marker vaccine. Criteria have not
    been set by which an objectively independent inventory of the problems could be
    made. The objective of this study was to determine management factors associated
    with the problem of 'chronic wasting' prior to the use of the BHV1 marker
    vaccine. Knowledge about these factors could be helpful for generating additional
    hypotheses about the aetiology of chronic wasting in cattle. A total of 188 farms
    participated in the study, of which 94 had severe problems with chronic wasting.
    The other half consisted of control farms matched with the case farms that did
    not report problems after the use of the BHV1 marker vaccine. Data analyses were
    performed over the period before (and not at the time of) 'chronic wasting'
    problems. Data were collected from various sources. A questionnaire was used to
    collect information on farm management practice. In addition, information on
    laboratory submissions for 1996 to 1998, animal movements in 1998, roughage
    analyses of 1997 and 1998, expenses for animal health in 1998, and herd
    performance in 1995 to 1999 was collected. In the analyses, a distinction was
    made between information obtained objectively and subjectively. Herds with
    problems of 'chronic wasting' were larger than herds without wasting problems
    (animals, surface) but not more intensively managed. 'Wasting' herds had a lower
    performance in terms of fertility and udder health. In addition, these herds had
    more contact with other herds through the purchase of animals. There were no
    differences in farm management practices related to disease control and
    prevention. Additional studies are required with regard to the patho-physiology
    of chronic wasting cows. The role of herd size needs more study.
     
  20. blob69

    blob69 Member

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    149
    Me: I’d like to research vaccines and wanted to ask about your general opinion since there is so much noise online. Do vaccines even work against the illness they are meant to work against? My impression is that science mixed up “inflammation” and “immune response” and that is why they are using dangerous adjuvants that trigger the inflammatory response. What is your view on that?

    Ray: Have you seen Suzanne Humphries’ things on vaccination? Your comment about inflammation vs immune response describes the situation exactly. I think inflammation is often a sign that the body’s resistance is low. The body is designed to handle viral and bacterial infections entering through the respiratory and digestive systems, and antigens of introduced by injection don’t produce the same reactions that the normally acquired infections do. The 20th century medical model of the immune system introduced by Paul Ehrlich was designed to promote the sale of drugs, and is corrupt at its core. Jamie Cunliffe (“damage”) and Polly Matzinger (“danger”) have introduced more biological models of immunity, that I think should displace the Ehrlich model. Good oxidative metabolism, with optimal vitamin D and thyroid function, gets people through epidemics without getting sick, despite being exposed to the thing that made others sick.

    Clin Transl Med. 2018 Jul 2;7(1):20.
    Cancer; an induced disease of twentieth century! Induction of tolerance,
    increased entropy and 'Dark Energy': loss of biorhythms (Anabolism v.
    Catabolism).
    Khatami M(1).
    (1)Inflammation, Aging and Cancer, National Cancer Institute (NCI), National
    Institutes of Health (NIH), Bethesda, MD, USA. mkgoodness@aol.com.
    Maintenance of health involves a synchronized network of catabolic and anabolic
    signals among organs/tissues/cells that requires differential bioenergetics from
    mitochondria and glycolysis (biological laws or biorhythms). We defined
    biological circadian rhythms as Yin (tumoricidal) and Yang (tumorigenic) arms of
    acute inflammation (effective immunity) involving immune and non-immune systems.
    Role of pathogens in altering immunity and inducing diseases and cancer has been
    documented for over a century. However, in 1955s decision makers in
    cancer/medical establishment allowed public (current baby boomers) to consume
    million doses of virus-contaminated polio vaccines. The risk of cancer incidence
    and mortality sharply rose from 5% (rate of hereditary/genetic or innate disease)
    in 1900s, to its current scary status of 33% or 50% among women and men,
    respectively. Despite better hygiene, modern detection technologies and discovery
    of antibiotics, baby boomers and subsequent 2-3 generations are sicker than
    previous generations at same age. American health status ranks last among other
    developed nations while America invests highest amount of resources for
    healthcare. In this perspective we present evidence that cancer is an induced
    disease of twentieth century, facilitated by a great deception of cancer/medical
    establishment for huge corporate profits. Unlike popularized opinions that cancer
    is 100, 200 or 1000 diseases, we demonstrate that cancer is only one disease; the
    severe disturbances in biorhythms (differential bioenergetics) or loss of balance
    in Yin and Yang of effective immunity. Cancer projects that are promoted and
    funded by decision makers are reductionist approaches, wrong and unethical and
    resulted in loss of millions of precious lives and financial toxicity to society.
    Public vaccination with pathogen-specific vaccines (e.g., flu, hepatitis, HPV,
    meningitis, measles) weakens, not promotes, immunity. Results of irresponsible
    projects on cancer sciences or vaccines are increased population of
    drug-dependent sick society. Outcome failure rates of claimed 'targeted' drugs,
    'precision' or 'personalized' medicine are 90% (± 5) for solid tumors. We
    demonstrate that aging, frequent exposures to environmental hazards, infections
    and pathogen-specific vaccines and ingredients are 'antigen overload' for immune
    system, skewing the Yin and Yang response profiles and leading to induction of
    'mild', 'moderate' or 'severe' immune disorders. Induction of decoy or pattern
    recognition receptors (e.g., PRRs), such as IRAK-M or IL-1dRs ('designer'
    molecules) and associated genomic instability and over-expression of growth
    promoting factors (e.g., pyruvate kinases, mTOR and PI3Ks, histamine, PGE2, VEGF)
    could lead to immune tolerance, facilitating cancer cells to hijack anabolic
    machinery of immunity (Yang) for their increased growth requirements. Expression
    of constituent embryonic factors would negatively regulate differentiation of
    tumor cells through epithelial-mesenchymal-transition and create "dual negative
    feedback loop" that influence tissue metabolism under hypoxic conditions. It is
    further hypothesized that induction of tolerance creates 'dark energy' and
    increased entropy and temperature in cancer microenvironment allowing disorderly
    cancer proliferation and mitosis along with increased glucose metabolism via
    Crabtree and Pasteur Effects, under mitophagy and ribophagy, conditions that are
    toxic to host survival. Effective translational medicine into treatment requires
    systematic and logical studies of complex interactions of tumor cells with host
    environment that dictate clinical outcomes. Promoting effective immunity
    (biological circadian rhythms) are fundamental steps in correcting host
    differential bioenergetics and controlling cancer growth, preventing or delaying
    onset of diseases and maintaining public health. The author urges independent
    professionals and policy makers to take a closer look at cancer dilemma and stop
    the 'scientific/medical ponzi schemes' of a powerful group that control a
    drug-dependent sick society before all hopes for promoting public health
    evaporate.
    Clin Transl Med. 2016 Dec;5(1):35.
    Is cancer a severe delayed hypersensitivity reaction and histamine a blueprint?
    Khatami M(1).
    (1)National Cancer Institute (NCI), the National Institutes of Health (NIH),
    Bethesda, MD, USA. mkgoodness@aol.com.
    Longevity and accumulation of multiple context-dependent signaling pathways of
    long-standing inflammation (antigen-load or oxidative stress) are the results of
    decreased/altered regulation of immunity and loss of control switch mechanisms
    that we defined as Yin and Yang of acute inflammation or immune surveillance.
    Chronic inflammation is initiated by immune disruptors-induced progressive
    changes in physiology and function of susceptible host tissues that lead to
    increased immune suppression and multistep disease processes including
    carcinogenesis. The interrelated multiple hypotheses that are presented for the
    first time in this article are extension of author's earlier series of
    'accidental' discoveries on the role of inflammation in developmental stages of
    immune dysfunction toward tumorigenesis and angiogenesis. Detailed analyses of
    data on chronic diseases suggest that nearly all age-associated illnesses,
    generally categorized as 'mild' (e.g., increased allergies), 'moderate' (e.g.,
    hypertension, colitis, gastritis, pancreatitis, emphysema) or 'severe' (e.g.,
    accelerated neurodegenerative and autoimmune diseases or site-specific cancers
    and metastasis) are variations of hypersensitivity responses of tissues that are
    manifested as different diseases in immune-responsive or immune-privileged
    tissues. Continuous release/presence of low level histamine (subclinical) in
    circulation could contribute to sustained oxidative stress and induction of
    'mild' or 'moderate' or 'severe' (immune tsunami) immune disorders in susceptible
    tissues. Site-specific cancers are proposed to be 'severe' (irreversible) forms
    of cumulative delayed hypersensitivity responses that would induce immunological
    chaos in favor of tissue growth in target tissues. Shared or special features of
    growth from fetus development into adulthood and aging processes and
    carcinogenesis are briefly compared with regard to energy requirements of highly
    complex function of Yin and Yang. Features of Yang (growth-promoting) arm of
    acute inflammation during fetus and cancer growth will be compared for consuming
    low energy from glycolysis (Warburg effect). Growth of fetus and cancer cells
    under hypoxic conditions and impaired mitochondrial energy requirements of
    tissues including metabolism of essential branched amino acids (e.g., val, leu,
    isoleu) will be compared for proposing a working model for future systematic
    research on cancer biology, prevention and therapy. Presentation of a working
    model provides insightful clues into bioenergetics that are required for fetus
    growth (absence of external threat and lack of high energy-demands of Yin events
    and parasite-like survival in host), normal growth in adulthood (balance in Yin
    and Yang processes) or disease processes and carcinogenesis (loss of balance in
    Yin-Yang). Future studies require focusing on dynamics and promotion of
    natural/inherent balance between Yin (tumoricidal) and Yang (tumorigenic) of
    effective immunity that develop after birth. Lawless growth of cancerous cells
    and loss of cell contact inhibition could partially be due to impaired
    mitochondria (mitophagy) that influence metabolism of branched chain amino acids
    for biosynthesis of structural proteins. The author invites interested scientists
    with diverse expertise to provide comments, confirm, dispute and question and/or
    expand and collaborate on many components of the proposed working model with the
    goal to better understand cancer biology for future designs of cost-effective
    research and clinical trials and prevention of cancer. Initial events during
    oxidative stress-induced damages to DNA/RNA repair mechanisms and inappropriate
    expression of inflammatory mediators are potentially correctable, preventable or
    druggable, if future studies were to focus on systematic understanding of early
    altered immune response dynamics toward multistep chronic diseases and
    carcinogenesis.
     
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