Ray Peat Email Advice Depository Discussion/Comment Thread

Beastmode

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Beet root sugar made in deterium depleted water

Me:
Have you found a reliable source online that produces beet sugar?

You've mentioned deterium depleted areas that produce them as something to consider, but finding the manufacturing areas they're produced is challenging.

Also, have you noticed a differences health wise using it compared to cane sugar?

Ray:
Unless it’s 100% depleted, the effects probably take a couple of years to notice. There’s a company in Missouri that makes it, I don’t know where it’s distributed.
 

boris

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Question


Ray Peat responded few hours back

Did he ever mention what he feeds his cat? If not, can someone ask him what he would reccomend for an indoor cat?
Available information on that is very conflicting.

My cats get raw meat with eggshell powder and taurine, but they don't like ruminant organs very much, they prefer lean muscle meat. Chicken stuff yes, but what you can get at the stores is pufa fed. One of them likes dairy, the other not. They get fed 3 times a day, but I am thinking since they are naturally active at dawn and dusk, would it make sense to fast them during the day?

I realized a hunting outdoors cat would naturally get some thyroid with almost every meal which is completely absent in muscle meat. I know he said cats have high metabolism, but mine don't poop often, at the very most once a day sometimes less. They had a super high PUFA diet for the first 5 years of their life so I suspect they might be hypothyroid.
 

raypeatclips

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Here are a few email exchanges I've had with Dr. Peat. I've left out the email formalities (greeting/thanks) from my end.

Me: I find it difficult to focus when drinking milk, and also seem to experience a drop in motivation. I've read that milk proteins have an opiate effect, leading to brain fog, difficulty concentrating, lack of motivation, etc. What do you think?

Peat: "Those experiments involves chemically altering the casein (producing peptides), and then injecting it into rats’ brains. It doesn’t occur when casein is digested."

Me: Does practicing backbending cause damage to the body? Is contortion damaging to the body? Why are some people more "naturally" flexible than others?

Peat: "When it hurts it is causing some damage. The balance of hormones affects the flexibility of the tissues."

Me: Why do I feel excessive sleepiness after consuming dairy products? It feels like a fog comes over me and I just have to go to sleep in the middle of the day, even if I do get enough sleep at night. This does not happen for products like butter where there is no dairy protein.

Peat: "Calcium, although it can increase the metabolic rate, can have a relaxing, antistress effect. Thyroid hormone sometimes has a similar effect."

Me: I appear to have Delayed Sleep Phase Disorder, where I cannot fall asleep until about 5 or 6 in the morning and then wake up at around 1 in the afternoon. I wonder what the cause of this could be, and how I can regulate my sleep cycle so that it is more "normal". Any thoughts?

Peat: "
Pantothenic acid, vitamin D, a high ratio of calcium to phosphate in your diet, a daily carrot for fiber to protect the intestine, thyroid hormone, progesterone, and, when intestinal inflammation is involved, an antihistamine such as cyproheptadine can help to restore the normal pattern."

Peat has always rubbished the cows dairy opiate theory but this is something I strongly disagree with him on. Goats milk and dairy has been a complete game changer for me. Try it yourself to see if there is a difference if you suspect it is an issue, regardless of what Peat says.
 

Kvothe

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Peat has always rubbished the cows dairy opiate theory but this is something I strongly disagree with him on. Goats milk and dairy has been a complete game changer for me. Try it yourself to see if there is a difference if you suspect it is an issue, regardless of what Peat says.

When I asked him a while ago he said:

"If protein digestion is poor, I suppose that difference would become more apparent."​

and

"Although I don't know of any evidence that ingesting the different caseins produces effects similar to injecting the peptides into the brain, poor digestion would create a condition in which it might happen"​
 
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T

tca300

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Similar conversation.

Ray Peat: " Its a peptide derived from partial digestion of casein; good digestion should reduce it to amino acids. "
 

Beastmode

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Serotonin and leadership

Me:
I heard of a study where they administered serotonin to low ranking monkeys in a pack and after administration, they became leaders in the pack.

Does this have to do more with becoming more aggressive, therefore becoming more dominant in your opinion?

Seems like leadership is mistaken for aggressiveness in a lot of literature and teachings I've come across.

Ray:
And in the military—leadership qualities overlap with cruelty and stupidity. A classmate of mine who talked about the importance of leadership, years later described his war crimes in Vietnam, and then was quoted as saying “I’m a professional, when the president says to shoot someone, I shoot them."
 

schultz

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Serotonin and leadership

Me:
I heard of a study where they administered serotonin to low ranking monkeys in a pack and after administration, they became leaders in the pack.

Does this have to do more with becoming more aggressive, therefore becoming more dominant in your opinion?

Seems like leadership is mistaken for aggressiveness in a lot of literature and teachings I've come across.

Ray:
And in the military—leadership qualities overlap with cruelty and stupidity. A classmate of mine who talked about the importance of leadership, years later described his war crimes in Vietnam, and then was quoted as saying “I’m a professional, when the president says to shoot someone, I shoot them."

Ray's classmate sounds like a moron. As always, gotta love Ray's response... "leadership qualities overlap with cruelty and stupidity"
 

Amazoniac

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A classmate of mine who talked about the importance of leadership, years later described his war crimes in Vietnam, and then was quoted as saying “I’m a professional, when the president says to shoot someone, I shoot them."
I don't think that this guy is just an obedient fool as it may sound. It can be that he wants to be violent without dealing with the guilt, so it's more than welcome when the responsibility is transfered to someone else that's detached from the consequences of the commands. It's bi-winning with uni-losing (target).

Ray's classmate sounds like a moron. As always, gotta love Ray's response... "leadership qualities overlap with cruelty and stupidity"
schultz, I don't know why you're involving religion, but 'military' can't be omitted.
 

Blossom

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I asked Ray about therapies for COVID-19 killing patients.

Me: "I recall you mentioning oxygen use as highly problematic. Today I heard a renowned pulmonology specialist explaining that in his opinion, patients with COVID-19 in Italy are dying due to excessive use of oxygen respirators. He cited some studies that showed a larger percentage of patients survive if not put on respirators.

The fact is that a large part of COVID-19 patients die in the most modern hospitals in Europe using the most modern equipment (i.e. Bergamo and Madrid). This video shows how they are being treated:

There is also this Italian nurse's tale - she explains that patients arrive to the hospital in a relatively stable state, but after an hour "look like zombies": Coronavirus, racconto choc dell'infermiera: "In un'ora precipita tutto..."

Do you think that the use of respirators could indeed be killing a large percentage of patients so quickly? Maybe combined with other toxic therapies like antivirals, antibiotics, antifungals, chloroquine etc.?"


Ray: "I think that’s exactly what’s happening, irrational use of oxygen and immunosuppressive drugs like chloroquine."

Some doctors seem to agree and feel ECMO should be used instead of mechanical ventilators. The survival rate once placed on one is abysmal as far as I can determine. It’s hard to get accurate #s.
 

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Diokine

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Consequences of Hyperoxia and the Toxicity of Oxygen in the Lung

Time course of inflammation, oxidative stress and tissue damage induced by hyperoxia in mouse lungs

Effect of oxygen on breath markers of oxidative stress
Supplemental oxygen is often administered to induce hyperoxia in nonhypoxic patients for indications such as chest pain, despite lack of evidence of clinical benefit. Induced hyperoxia is potentially toxic, since it may increase oxidative stress and peroxidative damage to deoxyribonucleic acid, lipids and proteins.

Bench-to-bedside review: the effects of hyperoxia during critical illness
In this context, oxygen may be recognized as a multifaceted agent, a modifiable risk factor, and a feasible target for intervention. Although most clinical outcomes are still under extensive investigation, careful titration of oxygen supply is warranted in order to secure adequate tissue oxygenation while preventing hyperoxic harm.

Supplementary oxygen in healthy subjects and those with COPD increases oxidative stress and airway inflammation


I also read some reports in China, where suspected cases of illness were diagnosed using clinical signs and chest CT imaging. In some cases, patients received up to FOUR chest CT's per day. Does anyone know the effect of radiation injury on the lung?
 

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The arterial PO2 is staying around 50 despite the high level of supplemental oxygen and that’s one reason why these people are intubated and mechanically ventilated much sooner than in other diseases. Some doctors feel ECMO would be a better choice but I think there are even less ECMO machines.
 

Diokine

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Thank you.

In cases like you're describing, what kind of oxygen levels would be supplied? I wonder about PaO2 levels and their relationship to supplied oxygen - if reducing from 70% to say 50% supplemental O2 didn't change blood gas concentrations, would it make sense to continue pushing high levels of O2? Do you think some doctors might treat a PaO2 of 50 mmHg aggressively, with very high oxygen concentrations? It seems apparent that possible lung injury from hyperoxia is well documented and well studied, and it seems difficult to imagine that many doctors would not be aware. At any rate it does seem ECMO may be superior notwithstanding the effects of pumping blood through an electromechanical device.
 

Blossom

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Thank you.

In cases like you're describing, what kind of oxygen levels would be supplied? I wonder about PaO2 levels and their relationship to supplied oxygen - if reducing from 70% to say 50% supplemental O2 didn't change blood gas concentrations, would it make sense to continue pushing high levels of O2? Do you think some doctors might treat a PaO2 of 50 mmHg aggressively, with very high oxygen concentrations? It seems apparent that possible lung injury from hyperoxia is well documented and well studied, and it seems difficult to imagine that many doctors would not be aware. At any rate it does seem ECMO may be superior notwithstanding the effects of pumping blood through an electromechanical device.
We are mandated to start every suspected covid-19 case on a 5 L nasal cannula which is @40% and if they do not improve we can go to a high flow (minimum 40 L flow) device and dial in whatever oxygen percentage is necessary (from 24-100%) if that doesn’t help we go immediately to intubation. Some hospitals will not do the high flow for fear of creating more aerosol/droplets that could spread infection. That may change tomorrow. They seem to be updating things frequently right now. ECMO seems better to me as well but I believe there’s less of them than ventilators. :(
 

Lee Simeon

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We are mandated to start every suspected covid-19 case on a 5 L nasal cannula which is @40% and if they do not improve we can go to a high flow (minimum 40 L flow) device and dial in whatever oxygen percentage is necessary (from 24-100%) if that doesn’t help we go immediately to intubation. Some hospitals will not do the high flow for fear of creating more aerosol/droplets that could spread infection. That may change tomorrow. They seem to be updating things frequently right now. ECMO seems better to me as well but I believe there’s less of them than ventilators. :(
Are you working at a hospital? Thank you so much for the work you are doing and you have my upmost respect <3
 

Blossom

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Are you working at a hospital? Thank you so much for the work you are doing and you have my upmost respect <3
Yes, thank you. That means a lot. I figured I’d share what I’m learning through this experience here if it can help us put our minds together and understand this better.
 

Blossom

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CLASH

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We are mandated to start every suspected covid-19 case on a 5 L nasal cannula which is @40% and if they do not improve we can go to a high flow (minimum 40 L flow) device and dial in whatever oxygen percentage is necessary (from 24-100%) if that doesn’t help we go immediately to intubation. Some hospitals will not do the high flow for fear of creating more aerosol/droplets that could spread infection. That may change tomorrow. They seem to be updating things frequently right now. ECMO seems better to me as well but I believe there’s less of them than ventilators. :(

In a case of ARDS (acute respiratory distress syndrome for anyone not familiar with the medical lingo :) ), the high flow oxygen shouldn't make to much difference, no? With the alveolar membranes damaged/ leaky, forcing more O2 seems like a situation of diminishing returns. ECMO would make more sense, to give the lungs a rest, however its a pretty invasive process inserting catheters into major arteries/ veins (especially when the catheters are somewhat massive lol).

The priority in my mind would be to reestablish the alveolar barrier by inhibiting the inflammatory process. I don't know the specifics of the viral infection beyond the ACE2 stuff, as I haven't looked into it that much, but the situation seems similar to ARDS from sepsis. If this is the case, then the trial with IV ascorbic acid, thiamine, and cortisone (perhaps replaced with progesterone/ pregnenolone/ DHEA) seems like a viable remedy.

https://journal.chestnet.org/article/S0012-3692(16)62564-3/fulltext

Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid

For the non-hospitalized individual perhaps a combination of these remedies may be helpful as well?
-ascorbic acid (camu camu, acerola, pineapple, rose hips)
-zinc + copper (oysters)
-progesterone, pregnenolone, DHEA
-B-vitamins
-Emodin from cascara
 
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Blossom

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In a case of ARDS (acute respiratory distress syndrome for anyone not familiar with the medical lingo :) ), the high flow oxygen shouldn't make to much difference, no?
Yes, personally I’d prefer if we were not doing it but I’m not on the committee that made that decision. I am just relaying our current protocol and in no way saying it’s ideal.
 

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