I would like help ranking the various metabolism friendly substances by anti-seratonin activity and by anti-inflammatory activity, and any help connecting the two mechanistically would also be appreciated. I have been following the work on Psychadelics for depression and reduced inflammation and while promising, it is missing the metabolic perspective of this community as well as the more readily available substances such as lisuride, cyprheptadine etc. Curiously, DOI, a little know psychedelic, has been shown to be hugely anti-inflammatory which might also be related to its seratonin receptor half life being quite long. All of these are also related to immuno-modulation and potential suppression in which we might also include substances like vitamin-d, vitamin-k, melatonin (another tryptamine) etc. Relatedly, I would like to know if higher metabolisms across populations induce more melatonin - thus more endogenous DMT synthesis during REM sleep. This seems the case across the life span...REM sleep decreases with age (as does melatonin). Here are some studies in this genre:
Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities
Psychedelics As A New Anti-Inflammatory Therapeutic For Atherosclerosis
Genetic and biochemical changes of the serotonergic system in migraine pathobiology
Melatonin has also been found to be altered in other central nervous system (CNS) disorders, such as stroke, obsessive-compulsive disorder, mood and schizophrenia [114, 115]. Melatonin has regulatory effects on gastrointestinal tract motility and sensation, has sleep promoting effects and mood regulation and anti-stress effects [116]. Consequently, it is not surprising that melatonin supplements have shown potential in diminishing pain intensity in migraine co-morbid conditions such as fibromyalgia and irritable bowel syndrome [116, 117].
Melatonin and N-acetylserotonin inhibit leukocyte rolling and adhesion to rat microcirculation. - PubMed - NCBI
REM Sleep Percentage in Children with Autism Compared to Children with Developmental Delay and Typical Development
Selective modulation of autophagy, innate immunity and adaptive immunity by small molecules
Increased IL-1β signaling also underlies a group of autoinflammatory syndromes, many of which respond clinically to IL-1β blockade.(37, 38) These include monogenic conditions such as cryopyrin associated periodic syndrome, as well as genetically complex diseases such as systemic juvenile idiopathic rheumatoid arthritis and Still's disease.
Enhanced functional connectivity and volume between cognitive and reward centers of naïve rodent brain produced by pro-dopaminergic agent KB220Z
Individuals suffering from a substance use disorder, are consequently affected by Reward Deficiency Syndrome (RDS), which is characterized by a hypodopaminergic state or trait. A hypodopaminergic state may result from the toxic effects of binge drug intake, or chronic uncontrollable stress and predisposes individuals to self-medicate to elevate or stimulate dopamine release (sup patent: https://www.google.com/patents/US20130195827)
https://www.ncbi.nlm.nih.gov/pubmed/26132915
Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities
Psychedelics As A New Anti-Inflammatory Therapeutic For Atherosclerosis
Genetic and biochemical changes of the serotonergic system in migraine pathobiology
Melatonin has also been found to be altered in other central nervous system (CNS) disorders, such as stroke, obsessive-compulsive disorder, mood and schizophrenia [114, 115]. Melatonin has regulatory effects on gastrointestinal tract motility and sensation, has sleep promoting effects and mood regulation and anti-stress effects [116]. Consequently, it is not surprising that melatonin supplements have shown potential in diminishing pain intensity in migraine co-morbid conditions such as fibromyalgia and irritable bowel syndrome [116, 117].
Melatonin and N-acetylserotonin inhibit leukocyte rolling and adhesion to rat microcirculation. - PubMed - NCBI
REM Sleep Percentage in Children with Autism Compared to Children with Developmental Delay and Typical Development
Selective modulation of autophagy, innate immunity and adaptive immunity by small molecules
Increased IL-1β signaling also underlies a group of autoinflammatory syndromes, many of which respond clinically to IL-1β blockade.(37, 38) These include monogenic conditions such as cryopyrin associated periodic syndrome, as well as genetically complex diseases such as systemic juvenile idiopathic rheumatoid arthritis and Still's disease.
Enhanced functional connectivity and volume between cognitive and reward centers of naïve rodent brain produced by pro-dopaminergic agent KB220Z
Individuals suffering from a substance use disorder, are consequently affected by Reward Deficiency Syndrome (RDS), which is characterized by a hypodopaminergic state or trait. A hypodopaminergic state may result from the toxic effects of binge drug intake, or chronic uncontrollable stress and predisposes individuals to self-medicate to elevate or stimulate dopamine release (sup patent: https://www.google.com/patents/US20130195827)
https://www.ncbi.nlm.nih.gov/pubmed/26132915