Randomised Clinical Study: Gluten Challenge Induces Symptom Recurrence In Only A Minority Of Patient

Discussion in 'Articles & Scientific Studies' started by Entropy, Sep 1, 2015.

  1. Entropy

    Entropy Member

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    Methods
    We studied 35 non-CD subjects (31 females) that were on a gluten-free diet (GFD), in a double-blind challenge study. Participants were randomised to receive either gluten-containing flour or gluten-free flour for 10 days, followed by a 2-week washout period and were then crossed over. The main outcome measure was their ability to identify which flour contained gluten. Secondary outcome measures were based upon Gastrointestinal Symptoms Rating Scale (GSRS) scores.

    Results
    The gluten-containing flour was correctly identified by 12 participants (34%), who were classified as having NCGS. Their mean GSRS dimension scores were significantly higher following gluten challenge compared to baseline.

    Conclusion
    Double-blind gluten challenge induces symptom recurrence in just one-third of patients fulfilling the clinical diagnostic criteria for non-coeliac gluten sensitivity.


    http://onlinelibrary.wiley.com/doi/10.1 ... 13372/full
     
  2. Such_Saturation

    Such_Saturation Member

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    Nov 26, 2013
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    How can it be blind? They'd be billionaires if the gluten-free bread was truly the same :ss
     
  3. OP
    Entropy

    Entropy Member

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    Apr 11, 2015
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    Yeah I don't know if I can take this flour sprinkled into soup study seriously...
     
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