Philomath
Member
One of the potential side effects of radiation therapy (RT) is vascular stenosis. Up until recently, the cause has been largely unknown.
For people going through RT for head and neck cancers, the risk of Carotid Artery stenosis is a factor of aprox 15%. Of course, reduced blood flow to the brain is a cause for strokes and even death.
This particular study outlines “new” thoughts on the cause of stenosis and radiation induced vascular disease:
Moreover, degeneration of the vascular smooth muscle, aggregation of foamy histiocytes and adventitial fibrosis have been observed. This is believed to be the precursor of lipid-laden foam cells and the beginning of atherosclerosis formation under the influence of pro-inflammatory cytokine release, such as interleukin(IL)-1, IL-6, tumor necrosis factor (TNF)-α, transforming growth factor-β (TGF-β). Among those, TGF-β is one of the most pleiotropic cytokines, affecting many cellular processes including epithelial cell growth, mesenchymal cell proliferation, and extracellular matrix synthesis (11). Ionizing radiation, even in low doses, induces TGF-β activation, affecting fibroblasts which are transformed into matrix-producing myofibroblasts and leading to fibrosis, a common feature observed in radiation induced heart disease.
www.frontiersin.org
What peaty methods can be employed to reduce the inflammatory cytokine release and fibrosis?
Naturally, the standards are red light, CO2, thyroid, & progesterone, but what about Solban & defibron? Are there others?
For people going through RT for head and neck cancers, the risk of Carotid Artery stenosis is a factor of aprox 15%. Of course, reduced blood flow to the brain is a cause for strokes and even death.
This particular study outlines “new” thoughts on the cause of stenosis and radiation induced vascular disease:
Moreover, degeneration of the vascular smooth muscle, aggregation of foamy histiocytes and adventitial fibrosis have been observed. This is believed to be the precursor of lipid-laden foam cells and the beginning of atherosclerosis formation under the influence of pro-inflammatory cytokine release, such as interleukin(IL)-1, IL-6, tumor necrosis factor (TNF)-α, transforming growth factor-β (TGF-β). Among those, TGF-β is one of the most pleiotropic cytokines, affecting many cellular processes including epithelial cell growth, mesenchymal cell proliferation, and extracellular matrix synthesis (11). Ionizing radiation, even in low doses, induces TGF-β activation, affecting fibroblasts which are transformed into matrix-producing myofibroblasts and leading to fibrosis, a common feature observed in radiation induced heart disease.
Radiation-Induced Vascular Disease—A State-of-the-Art Review
Since the 1990s, there has been a steady increase in the number of cancer survivors to an estimated 17 million in 2019 in the US alone. Radiation therapy today is applied to a variety of malignancies and over 50% of cancer patients. The effects of ionizing radiation on cardiac structure and...
What peaty methods can be employed to reduce the inflammatory cytokine release and fibrosis?
Naturally, the standards are red light, CO2, thyroid, & progesterone, but what about Solban & defibron? Are there others?
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