- Jan 5, 2016
maybe also of interest:
QUININE THERAPY IN CASES OF MULTIPLE SCLEROSIS OVER A FIVE YEAR PERIOD June 1935The study of quinine therapy in cases of multiple sclerosis has been in progress for five years. In an earlier report,1 presented about fourteen months after the study was commenced, it was stated that quinine therapy appeared to have promise. The experience of five years with forty-nine patients...jamanetwork.com
Is multiple sclerosis caused by a silent infection with malarial parasites? A historico-epidemiological approach: part IIIn 1935 the world's literature on the subject of the treatment of multiple sclerosis was reviewed by Brickner.1 He emphasized the factors which made scientific investigation in the field of treatment of multiple sclerosis difficult, the most important being the notorious unpredictability of the...jamanetwork.com
The comparison between the old map of malaria and the later distribution of multiple sclerosis (MS) first carried out in the USA (Part I) is continued in Europe. The Italian 'dilemma' (Kurtzke), meaning the disappearance of the north-south gradient in Italy by recent surveys, can be solved when considering the dependence of malaria transmission in relation to the altitude. Further, the high prevalence of MS in earlier times in Mississippi, Louisiana and in the former province of Lucania in Italy can be explained by preceding epidemics of malaria. Brickner's therapeutic trial with quinine in cases of MS patients is reevaluated, and by this the Jarisch-Herxheimer reaction is shown to exist in MS too. The possible significance of the old and rather forgotten provocative methods for the diagnosis of latent malaria is discussed.
Thanks, I had to find a map for myself. I am wondering if a gain-of-function strain of malaria could revive the prevalence of malaria in parts of the world shown in the old maps.