Pyrucet - Liquid (ethyl) Pyruvate/Aceatoacetate Mix

Discussion in 'IdeaLabs' started by haidut, Jan 30, 2019.

  1. OP
    haidut

    haidut Member

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    Thanks Bruce! Keep us posted please.
     
  2. OP
    haidut

    haidut Member

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    So, are you saying EP is already known in the CFS community? Can you please send some links where they discuss it on other forums?
     
  3. OP
    haidut

    haidut Member

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    Well, the studies that I posted show that pyruvate does activate PDH in a sort of a positive feedback cycle. So, even if come pyruvate gets converted to lactate the net effect is still increases glucose oxidation. Also, the acetoacetate should be able to reduce/prevent the lactate formation as it is another oxidizing agent that can keep PDH running. PDH activity depends primarily on the redox ratio (assuming deficiency of cofactors like thiamine is not an issue), and since both agents increase strongly NAD/NADH ratio that is probably what prevents the lactate buildup.
     
  4. OP
    haidut

    haidut Member

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    That's what one of the studies seemed to show, because neither ethanol nor pyruvate were able to replicate the effects, and giving ethanol + pyruvate together did not either. So, there is something about ethyl pyruvate as whole molecule that enables these effects and it is probably its stability and resistance to metabolism by LDH.
     
  5. OP
    haidut

    haidut Member

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    Thanks. Magnesium is also a cofactor for glucose metabolism so sounds plausible. Also, as I mentioned earlier in the thread, make sure it is always consumed with sugar as t increases its metabolism and some of the studies in the original post showed that the benefits of EP/EA manifest mostly when given together with glucose/carbs.
     
  6. mirc12354

    mirc12354 Member

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    Could You please elaborate on Mildronate toxicity you are mentionig in this thread?
     
  7. Dave Clark

    Dave Clark Member

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    I didn't mean to say that you suggested it, I was just trying to understand why GSH depletion would be a good thing in a non-cancer person. I see where it says about the anti-inflammatory effects. I also was under the impression that having high amounts of cellular GSH was a good thing for a healthy person. Like I said, I am still learning so this may make sense to me as i become more educated (I am self taught, I don't have a degree in biochemistry, medicine, etc.)
     
  8. OP
    haidut

    haidut Member

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    For most people GSSG/GSH ratio is too low for optimal health and lowering GSH increases that ratio.
     
  9. OP
    haidut

    haidut Member

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    Where did you see me saying Mildronate is toxic?
     
  10. OP
    haidut

    haidut Member

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    So, we try to both actually and it gets confusing. The units are for measurement purposes but as far as the supplements are concerned we also try to make a dosage split that would make the bottle last 30 days if used at that dose. It just so happens that the 500mg EP/EA daily more or less match the doses used in the animal studies.
     
  11. Mufasa

    Mufasa Member

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    Do you have a reference for that?
    Very often the exact opposite is claimed.

    Not saying that I disagree, but I would like to read more evidence.
     
  12. BRMarshall

    BRMarshall Member

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    Day 2 mid morning

    7 drops of Pyrucet on wrist
    4 drops Diamant
    4 drops Cardenosine

    While taken at the same time, I did feel a 'shift' similar to my first experience with
    Pyrucet, so definitely there is a signature to the substance, and one that I certainly like!.

    Distinct and unique and one different from that of Daimat and Cardenosine which I am familiar with.

    I took the smaller dose to try to understand what the parameters of response to it might be, and where there
    might be the option to pace one's dose through out the day, or towards understanding what might constitute
    a minimum booster dose.

    My understanding, and this is not a 'lab rat' experiment, but a experience with a GRAS combo, thus far is that Pyrucet
    has some important components towards addressing "learned-helplessness" and perhaps thus serve as a nutritional adjunct
    to mitigating addiction strategies such that Broda Barnes for example said that alcoholism was a problem of sugar
    nutrition and thus alcohol a form of rocket fuel per say, or that marijuana is an addiction to a blood rush of what is
    a temporary head feeding....

    While my reflections are topical, time will tell with further experimentation, without other substances, to further
    understand one's response of which today I had a few smiles that I believe were gently induced by such nutritional
    support.
     
  13. vetiver

    vetiver Member

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    I think this is on the Phoenix Rising forums?
    Would lowering the GSH/GSSH be negative for someone with heavy metal toxicity?
     
  14. ddjd

    ddjd Member

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    Methylene blue raises Serotonin
     
  15. truegrit

    truegrit Member

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    Methylene blue doesn't raise serotonin an appreciable amount in the dosages frequently recommended on these forums - only outsize doses seem to do that. Anything under 1mg seems to have a negligible/non-significant effect on serotonin.
     
  16. mirc12354

    mirc12354 Member

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    "So, I spend a lot of time over the last year looking for chemicals that work similarly to Mildronate but without toxic side effects."
     
  17. amaranthine

    amaranthine Member

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    From the sentence just above your quote: “Unfortunately, with the exception of Mildronate all other clinically used FAO have severe side effects, which greatly limit their use.”

    So he was saying that other clinical chemicals that inhibit FAO, like mildronate does, have toxic effects, not mildronate itself.
     
  18. SB4

    SB4 Member

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    I have purchased some and will look forward to seeing if it can help my CFS/POTS symptoms. I can see it going either way, either forcing glucose use with a stubborn PDH could result in even less energy and even more lactate accumulation, or perhaps it turns on PDH and allows carbs to be used with minimal heart symptoms.

    @haidut I have had limited success with using MCT oil with carbs in order to supply excess acetylCoA and force pyruvate down to oxaloacetate and avoid PDH (at least I think that's why it helps). Could ethyl aceatoacetate act in a similar mannor in high enough dose? Could it supply suffient acetyl CoA to help pyruvate avoid PDH? Do you know of any other substances that could do this (aside from alcohol and exogenous ketones)? Problem with MCT is I get diarhea even at relatively small doses.
     
  19. Vinero

    Vinero Member

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    Is it ok to take pyrucet if a person also takes Niacinamide and Aspirin? Or is it better to drop those?
    Since Niacinamide and Aspirin also inhibit free fatty acids, adding Pyrucet might be too much inhibition of free fatty acids?
     
  20. GAF

    GAF Member

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    Got 2 Bottles in the mail 30 minutes ago

    Got a spoon. 20 drops. I ate it. Nearly Died. DO NOT DO THIS! tastes super bad and burns! Washed down with coffee. Ok Now. No Permanent Damage.

    Put 10 drops on GF forearm.

    Gotta run to a lunch meeting. Fingers seem to be typing really fast.
     
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