I normally take 10 to 15 drops orally and I try to make sure my blood sugar doesn't become low from doing so. Haidut said this stuff can be applied to the belly button in much smaller doses (roughly 4-5 drops if I remember correctly) if you also use some ethanol to rub it in, but ethanol is required for this to be really effective, and I can't get that stuff up here in Canada. I can't even get Everclear vodka up here for a decent price.Applied topically to the knees? What dosage? My dad has arthritic knees I may ey this on him. Thanks!