- Jul 8, 2019
From OP: "EP also exerts anti-apoptotic effects, increases heme oxygenase-1 expression..." which pyruvate itself doesn't do.
RP wrote that heme oxygenase produces carbon monoxide and that its production is stimulated by estrogen and pituitary hormones like ACTH, prolactin, etc. which obviously are not good.
I appreciate your posting your concern, lampofred. I always want to hear concerns like this.
I know that when I've tried to take Pyrucet daily for an extended period, even at a very low dose, it makes me manic.
But if you're coming out of something really bad, like cancer, there's nothing else like it. You don't need the official cancer diagnosis to know you're in serious trouble. Then you take this and you know you've escaped, at least for a while.
Same thing if you neglected to take D3 and thyroid all winter and at the end of the winter you find yourself in a serious hole.
So I wouldn't try to use this as a replacement for thyroid or progesterone but if you're in serious trouble, it's very nice to have around to help you regroup.
Edit: Since HO-1 is a heat shock protein, here is Ray Peat on how heat shock proteins work and at what cost (starting at 20:85 with an important summary at roughly 27:00).