Pyrucet - Liquid (ethyl) Pyruvate/Aceatoacetate Mix

Discussion in 'IdeaLabs' started by haidut, Jan 30, 2019.

  1. Nokoni

    Nokoni Member

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    True, the logic may be sound but I'm always suspicious of autoimmune explanations. MS is more likely an energy/vitamin deficiency and rheumatoid arthritis is more likely a boron deficiency. The other issue is that most drugs have many effects that are completely unsuspected. Like SSRI's that actually help with depression turn out to have beneficial inhibition of certain serotonin receptors. That may turn out to be the case with rituximab also. Maybe it does actually help but through some as yet unknown mechanism of action. My joke was more about the seeming fact that the first impulse of the medical establishment is to poison, burn, or cut off some apparently evil tissue. Not saying it's wrong, but even if the theory is correct that something turned the cells away from glucose oxidation, down-regulating beta-oxidation with pyrucet is probably safer.
     
  2. johnwester130

    johnwester130 Member

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    CFS could be a morgellons/vaccine/conspiracy related illness too
     
  3. SB4

    SB4 Member

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    I'm pretty sure the phase 3 results have been out for a couple years now and it was not much different than control unfortunately. There is some speculation of why this could be but the results for CFS with Rituximab where disappointing.

    I think there is a decent probability that PDH is being inhibited somehow in CFS thanks to my own symptoms. Soon after eating carbs my symptoms (particulary heart pounds) and also lactic acid build up from minimal exertion, increase. This is somewhat mitigated by MCT oil with carbs suggesting that the MCTs are used alongside carbs (as opposed to LCT) to aleviate some of the enery deficit caused by PDH inhibition. If that is actually happening of course.

    I didn't notice much in regards to symptoms improvement from Pyrucet though.
     
  4. johnwester130

    johnwester130 Member

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    Fuel Shortage: Norwegian Study Expands on Energy Problem in Chronic Fatigue Syndrome (ME/CFS) - Health Rising

    have you tried a acetyl-coa supplement by swanson ?

    or mildronate ? this seems far stronger and effective.

    Yes, peat wrote specifically about mildronate and coconut oil in his article and how it is digested.
    Coconut Oil
     
  5. SB4

    SB4 Member

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    Hey, John. I haven't tried that supp, have you? I just gave it a look and it is only the precursors to acetylCoa and its low dose, I think you would be needing to take grams of A coA equivalent to have noticeable effect.

    You tried mildronate? I just looked it up and it seems its mechanimsm of action is through inhibiting fat transport to mito, forcing glucose use, and also increasing vasodialation. Whilst forcing glucose use could overcome the PDH problems I tend to think that it will make me even worse by stopping any energy from fat and significantly increasing lactic acid. There is also the vasodialation which is probably going to upset my POTS and blood pooling.
    If I hear any good reviews for it with CFS symptoms I might be tempted though.
     
  6. johnwester130

    johnwester130 Member

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    there is a calcium pyruvate capsule at 1000mg

    mildronate looks interesting to experiment with, i don't know if it will cure cfs
     
  7. SB4

    SB4 Member

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    @johnwester130 The thing with the calcium pyruvate is that if PDH is inhibited, wouldn't providing more pyruvate just end up being converted to lactate? Although it isn't as bad, you still run into the problem of not being able to consume much pyruvate that way. It seems to be a 5:1 ratio of pyruvate grams to calcium. 1g of Ca = 5g of Pyruvate, plus it would be very expensive.

    Having said that, Ron Davis did find it brought his nano needle experiment back into normal range. Perhaps exogenous pyruvate could work some other way.
     
  8. johnwester130

    johnwester130 Member

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    Does mildronate work on the "pyruvate system " ?

    User reviews say it reduces all muscle pain, and soldiers and athletes use it. I really think it can work. Anecdotally it reduces lactic acid too.
     
  9. SB4

    SB4 Member

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    If you try it I would be very interested in the results. Looking at wikipedia it appears the mechanism of action is inhibiting fat transport into the cell. My fear here is that this will cause a bigger energy deficit and more lactic acid as I do best with fats and worse with carbs. But it could force PDH activation or do something else that helps glucose be oxidised by mito.
     
  10. johnwester130

    johnwester130 Member

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    after reading this, i am convinced of it.

    Maria Sharapova Tested Positive For A Drug Ray Peat Talked About

    here is how it works
     
  11. SB4

    SB4 Member

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    If you give it a go then keep me posted on what happens to you symptoms wise. If you get good results I might give it a shot. Do you have noticable trouble with carbs?
     
  12. johnwester130

    johnwester130 Member

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    personally, no, I handle carbs well.
     
  13. milkboi

    milkboi Member

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    I will try Mildronate too in the next months. Why would it stimulate NO tho? I would have thought it would rather stimulate CO2 production due to increased (full) oxidation of sugar, therefore making NO superfluous.
     
  14. johnwester130

    johnwester130 Member

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    I don't know. Peat speaks highly of it, I doubt he would reccomend something that increase NO
     
  15. johnwester130

    johnwester130 Member

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    I have noticed mid day sleepiness is gone - a problem i had for 8 years.

    Still aching muscles though
     
  16. SB4

    SB4 Member

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    Thats good, shame it not doing much for muscles. How long have you been on it?
     
  17. johnwester130

    johnwester130 Member

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    5 days now
     
  18. Fon

    Fon Member

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    You're blowing my mind, Haidut. I have been taking N.AC. for quite a while, and not more than an hour ago, I just ordered some liposomal glutathione. Now u are telling me that this stuff is bad for you? That it is doing damage to my body? Can anyone please explain? I dont get it.
     
  19. Fon

    Fon Member

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    In layman's terms
     
  20. tallglass13

    tallglass13 Member

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    @haidut, can Pyrucet be used in place of a Sodium Butyrate supplement?
     
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