Kingpinguin
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- Joined
- Aug 14, 2019
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- 586
Differential Metabolic Effects of Saturated Versus Polyunsaturated Fats in Ketogenic Diets
Changes in serum β-hydroxybutyrate, insulin sensitivity (SI), and lipid profiles were measured. Mean circulating β-hydroxybutyrate levels increased 8.4 mg/dl in the POLY group (P = 0.0004), compared with 3.1 mg/dl in the SAT group (P = 0.07).
beta-Hydroxybutyric acid - Wikipedia
In epilepsy patients on the ketogenic diet, blood β-hydroxybutyrate levels correlate best with degree of seizure control. The threshold for optimal anticonvulsant effect appears to be approximately 4 mmol/L.[11]
Our data demonstrate that short-term administration of a diet high in polyunsaturated fats induces a greater level of ketosis and improves SI without negatively affecting total or LDL cholesterol levels, compared with a traditional KD high in saturated fats. It has been suggested that the therapeutic efficacy of the KD in patients with epilepsy is related to the level of serum BOHB (20). Our findings indicate that the POLY KD is capable of achieving a level of ketosis greater than that from a traditional SAT KD in humans and are consistent with results obtained in animals (15).
Consistent with these data, we found that a SAT KD, despite being less ketogenic than a POLY KD, induced unfavorable changes in circulating lipids and lipoproteins and did not improve SI. This implies that a POLY KD may be preferable for chronic administration. Consistent with this postulate is a recent report that levels of polyunsaturated fatty acids, notably arachidonate and docosahexanoate, were elevated in sera of patients with epilepsy who were treated with KDs (23). Furthermore, seizure control correlated with circulating concentrations of arachidonate (23).
Anyone know what B S this is?
Not that I’m interested in keto diet, ketosis or high PUFA intake anyhow. But this just goes against what I believe I’ve heard and many other heard. I thought saturated fat was GABAeric and not PUFA.
Changes in serum β-hydroxybutyrate, insulin sensitivity (SI), and lipid profiles were measured. Mean circulating β-hydroxybutyrate levels increased 8.4 mg/dl in the POLY group (P = 0.0004), compared with 3.1 mg/dl in the SAT group (P = 0.07).
beta-Hydroxybutyric acid - Wikipedia
In epilepsy patients on the ketogenic diet, blood β-hydroxybutyrate levels correlate best with degree of seizure control. The threshold for optimal anticonvulsant effect appears to be approximately 4 mmol/L.[11]
Our data demonstrate that short-term administration of a diet high in polyunsaturated fats induces a greater level of ketosis and improves SI without negatively affecting total or LDL cholesterol levels, compared with a traditional KD high in saturated fats. It has been suggested that the therapeutic efficacy of the KD in patients with epilepsy is related to the level of serum BOHB (20). Our findings indicate that the POLY KD is capable of achieving a level of ketosis greater than that from a traditional SAT KD in humans and are consistent with results obtained in animals (15).
Consistent with these data, we found that a SAT KD, despite being less ketogenic than a POLY KD, induced unfavorable changes in circulating lipids and lipoproteins and did not improve SI. This implies that a POLY KD may be preferable for chronic administration. Consistent with this postulate is a recent report that levels of polyunsaturated fatty acids, notably arachidonate and docosahexanoate, were elevated in sera of patients with epilepsy who were treated with KDs (23). Furthermore, seizure control correlated with circulating concentrations of arachidonate (23).
Anyone know what B S this is?
Not that I’m interested in keto diet, ketosis or high PUFA intake anyhow. But this just goes against what I believe I’ve heard and many other heard. I thought saturated fat was GABAeric and not PUFA.