PUFA Effects Well Known In Australia

haidut

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Look at this article and focus especially on facts #8, #11, and #12. Apparently, in some medical circles in Australia it is well known what causes heart disease and cancer.

http://www.businessinsider.com.au/how-c ... at-2013-11

And this study actually goes as far as to say that high cholesterol is protective against CVD. And no, Peat was not one of the authors:):
http://qjmed.oxfordjournals.org/content/96/12/927

"...Many researchers have suggested that the blood lipids play a key role in the immune defence system.1–,21 There is also a growing understanding that an inflammatory response of the arterial intima to injury is a crucial step in the genesis of atherosclerosis. and that infections may be one type of such injury.22 These two concepts are difficult to harmonize with the low-density-lipoprotein (LDL) receptor hypothesis, according to which high LDL cholesterol is the most important cause of atherosclerosis. However, the many observations that conflict with the LDL receptor hypothesis, may be explained by the idea that high serum cholesterol and/or high LDL is protective against infection and atherosclerosis."
 

burtlancast

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Yes, they all come from the land down under...
 

tara

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Sheila

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Well known in a very, very small circle I regret to say. Slightly smaller than this .
This program caused uproar - as one might expect and was widely trashed in the media and all other vested interests and parties.
The general public no longer knows what to think, except sugar is probably bad for you...that's the latest, this week.
Luckily it is sunny here even if the Cancer Council and others think sunshine gives you cancer too.
So no, not a bastion of PUFA understanding here. Fish oil, for example, is one of Blackmores (large supplement company) best sellers.
Sheila.
 

burtlancast

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Here's an extract from the recently transcribed interview on Type 2 Diabetes, where Ray explains the real cause of nerve damage in diabetics: he claims it's the failure to produce protective steroids (pregnenolone, progesterone, ...) by the balancing steroid system (which normally counters the small estrogen production during moderate stresses by an abundance of protective steroids), that causes nerves tissues to degenerate.
When their energy producing machinery is poisoned by an excess of FFAs, this protection mechanism fails.

Glucose has nothing to do with it.

RP: I’ve gone through many articles, recently I watched a video by Gershom Zajicek, who’s a very amazing biology medical professor in Israel. He has a very good understanding of physiology, and he has a video on diabetes and explains how the increased blood glucose is called for by the brain to make up for its needs. But after explaining the compensatory effect of high glucose for the brain, he uses the term glycotoxic, for the harmful effects supposedly of glucose. And, basically, he just resorted to a word to explain how glucose affects the other organs. And, looking through the literature, I see that people do that without really explaining what’s happening, why extra glucose would be harmful; if it’s within a moderate osmolarity, the mechanism just isn’t explained, even though they say it’s doing the harm. The changes in the nerves, include everything that is failing because of lack of energy. And when the cells are known to be living on fatty acids, and the fatty acids are intrinsically disturbing the metabolism of phosphate, turning off glucose energy production, slowing it down, even activating nitric oxide, the respiratory inhibitor, you know that the energy of the cell being reduced, is going to slow all kinds of repairing processes.

And, incidentally, in the pancreas, glucose stimulates regeneration of new insulin producing cells. And it’s the bad balance (too much FFAs and not enough glucose to defend the cells) that causes them to die. And anywhere else that a cell is deprived of it’s energy and forced to eat fatty acids instead… that’s now well recognized in heart failure: a simple treatment such as niacinamide can restore great amounts of heart energy production and improve the failure. Drugs are being developed to do the same as aspirin and niacinamide.

But in nerves, one of the effects of failing energy is the inability to make cholesterol and convert cholesterol into the neurosteroids; when a nerve (or its supporting cells, the glial cells) when they’re injured by anything, including lack of glucose or a lack of oxygen, they not only stop producing the defensive steroids from cholesterol, but they begin producing estrogen. And the diabetic brain and nerves, and all of the diabetic tissues, have more aromatase than a normal person of the same age (more of the enzymes which convert androgens to estrogens).

And the estrogen in a healthy personwhen a nerve is stressed, the activation of these enzymes which are normally inactive in a nerve… stress activates the production of a little estrogen which sends out signals to the surrounding cells to cause them to produce pregnenolone, progesterone, allopregnanolone and a whole range of protective nerve steroids...but if you don’t have the energy, you get stuck in producing just the estrogen, which keeps things excited and stressed.
 

Sheila

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Burtlancast, thanks so much for posting this. Just what I needed to read to refocus.
And, indeed, for all the transcription work you and others have done tirelessly.
After that, who knows, the effects of PUFA might become 'well known' Down Under after all.
Thank you again, sincerely
Sheila
 

burtlancast

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You welcome, Sheila. :D

The amazing thing about these interviews is i don't recall reading this exact explanation inside Ray's posted articles on diabetes.

( i might be wrong, though) ?
 

burtlancast

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Here's an expansion from my above quoted extract about phosphate ions and energy production
And when the cells are known to be living on fatty acids, and the fatty acids are intrinsically disturbing the metabolism of phosphate, turning off glucose energy production

found in the second interview on diabetes, posted today: It seems it's the PUFA's indirect effect on increasing free phosphate ions that inhibits the pyruvate dehydrogenase enzyme (which is the crucial enzyme at the top of the energy producing chain) that causes the decreasing cell energy production.

But another substance which uncouples mitochondria also lowers ATP a little bit and greatly protects the mitochondrion from free radicals, that’s fructose! Fructose absorbs excess phosphate ions (probably that’s related to why it lowers the ATP). But the absorption of the phosphate ions by fructose is, in a way, a direct defensive system of the oxidative system: because the pyruvate dehydrogenase enzyme ,which is suppressed in cancer, is why dichloroacetate is gaining so much interest, because it’s a chemical that reactivates pyruvate dehydrogenase and improves the cancer metabolism in a great variety of tumors. But simply lowering the free phosphate in the cell tends to reactivate this crucial enzyme at the top of the energy producing chain. And when you are supplied with aspirin, caffeine and fructose, for example, you’re not calling on FFAs. If you load up the cell with excess FFAs (for example, from some stress), the FFAs reverse all of those processes; they block pyruvate dehydrogenase by making more phosphate ions available, where the sugars instead bind them, and lower the free phosphate ions. Fatty acids increase them (the phosphate ions) and then tend to poison the crucial enzyme.
 

tara

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burtlancast said:
post 107471
The amazing thing about these interviews is i don't recall reading this exact explanation inside Ray's posted articles on diabetes.

( i might be wrong, though) ?
I have not read these explanations in his articles on his website either (though I haven't read many of his newsletters). It's such fun finding new bits like this.
Always so much more to learn. :)
 
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chispas

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Except that the militaristic Australian Heart Foundation puts star ratings and ticks of approval on every omega-3 and iron enriched product in the shops, with their ugly recommendations endorsed by all the mainstream media. I often joke with my colleagues that I base my own health choices on doing the binary opposite of what the AHF recommends.
 

chispas

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There are some people in Australia who are starting to publicize Ray Peat, such as the personal trainers at Nustrength in Queensland and nutritionist Emma Sgourakis in Victoria.
 

chispas

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The other thing that should be mentioned in this thread is the blind acceptance that Australian sun leads to melanoma. Great money making enterprise for wealthy skin specialists in Australia. Nevermind that young children die of melanoma without even venturing into the sun, and yet the same explanation is given.
 

Agent207

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Look at this article and focus especially on facts #8, #11, and #12. Apparently, in some medical circles in Australia it is well known what causes heart disease and cancer.

http://www.businessinsider.com.au/how-c ... at-2013-11

Why do you take an article and use it as an example to corroborate a determined position, and picking just selected parts at your convenience and hidding others, instead of analizing it in context to expose it's whole idea?

Or didn't you see part 13. Why the Mediterranean diet worked?
Then one can understand the article sees not only just n-6 as bad, but the lack of a balanced ratio with the n-3 too.

That article you linked in its whole, matches more with my criteria and the studies posted about the significance of a balanced ratio on n6:n3 than what you echoes with.


As for the cholesterol ridiculous stigma there's no need to seek in remote journals or blogs; Uffe Ravnskov has been talking about this since 1991, and much before Peat btw.
 
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Luann

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mujuro

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There are some people in Australia who are starting to publicize Ray Peat, such as the personal trainers at Nustrength in Queensland and nutritionist Emma Sgourakis in Victoria.

Are they taking full credit? Nothing annoys me more. A famed GH researcher in bodybuilding circles regularly had the work published on his private forum plagiarized. Except he commanded enough respect across the bodybuilding culture that said plagiarism was usually called out and the plagiarizer heckled into obscurity.
 

chispas

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Australia's government would probably love to con the country into the "seed oil = heart health" group.

This is random, but take a look at this migraine med from 2006 that treats pain by upregulating cholesterol synthesis and slowing SC-desaturase at the same time : )
The messenger RNA profiles in liver, hypothalamus, white adipose tissue, and skeletal muscle of female Zucker diabetic fatty rats after topiramate treatment

Wherever there are wheat farmers I suppose, given that they supplement their income by selling pressed oil to incorporate into food for livestock and every other thing they can find. I don't know how they reconcile the idea of using the omega 6 oil as a preservative when they are well aware how oxidised and rancid it becomes sitting at room temperature.

Do they have rocks in their heads?
 
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