Hi everyone. As you know I have PSSD from SSRI use. SSRIs caused me hashimoto, with severe hypothyroidism. Despite the integration of T3 and T4 I don't solve the problem. My temperatures are low, metabolism slow, breathing hard, dry skin, hair loss, no libido, erectile dysfunction.
I have found that PSSD does not benefit from levothyroxine / liothyronine or the dried thyroid extract itself, but from an upstream process. When the body is in a low thyroid state after the suspension of external replacement, it begins to produce a lot of TRH through the hypothalamus to stimulate the production of TSH by the anterior pituitary.
TRH has a lot of other pharmacological actions besides its effect as a hormone. I need to update my knowledge on it as it has been a long time but I can remember that it is closely related to dopamine release mechanisms. Also:
I have found that PSSD does not benefit from levothyroxine / liothyronine or the dried thyroid extract itself, but from an upstream process. When the body is in a low thyroid state after the suspension of external replacement, it begins to produce a lot of TRH through the hypothalamus to stimulate the production of TSH by the anterior pituitary.
TRH has a lot of other pharmacological actions besides its effect as a hormone. I need to update my knowledge on it as it has been a long time but I can remember that it is closely related to dopamine release mechanisms. Also:
What do you think? How to solve the problem? Thank you all!Il TRH esercita anche una varietà di effetti sul sistema nervoso centrale indipendenti dalla sua attività sull'asse HPT. Con l'avanzare dell'età, sono state dimostrate diminuzioni nella sintesi, espressione e attività di TRH. Associato a questa evidenza emergente suggerisce che TRH è implicato nelle malattie neurodegenerative dell'invecchiamento, tra cui il morbo di Alzheimer e il morbo di Parkinson. Il TRH ei suoi analoghi sintetici sono stati riconosciuti come fattori trofici nei neuroni del diencefalo e del midollo spinale e come neuroprotettori contro lo stress ossidativo, la tossicità del glutammato, la morte cellulare indotta dalla caspasi, la frammentazione del DNA e l'infiammazione. In questa recensione, forniremo una panoramica di alcuni dei ruoli di TRH, al di fuori dell'asse HPT.