Proviron Supresses T In Teenagers

Discussion in 'Scientific Studies' started by André Luiz, Oct 27, 2019.

  1. André Luiz

    André Luiz Member

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  2. Kingpinguin

    Kingpinguin Member

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    Interesting. Seems like they saying it did supress total T and lowered protein bound T aka SHBG bound testosterone. But it did not affect free testosterone levels and it did not affect the pituitary to stop sending signals to stop T production. I would not say that this means supression. Because it did not supress the pituitary. And free T remained the same. So your title is misguiding. On top of that it did supress SHBG bound which makes sense because mesterolone is know o have higher affinity for SHBG than testosterone so it binds up all SHBG so that theres none left for T to bind. In all this study is rather great because it means you can use mesterolone for its androgenic effect and still stop it without having to wait for pituitary to start again and also it didnt even affect free testosterone.
     
  3. tankasnowgod

    tankasnowgod Member

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    75 and 150 mg per day are massive, un-physiologic doses. Isn't normal levels of DHT produced in a healthy teenage male under 10mg daily?
     
  4. Kingpinguin

    Kingpinguin Member

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    That aswell
     
  5. Cameron

    Cameron Member

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    About 1mg dht and around 6-8mgs of testosterone in healthy males
     
  6. vulture

    vulture Member

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    Body doesn’t produce Mesterolone, BTW, and it’s not DHT, also.
    When I toke 25 to 50 mg my T rose from 800 to 900 levels. Two weeks.
    It’s a mystery for me what’s the mechanism for that T drop, there are studies on high dosages where it drops E2 and T significantly, don’t know why. But seem a like low doses isn’t that simply to say that’s is supressive, there are studies saying it’s not
     
  7. bdawg

    bdawg Member

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    for you its likely the E2 drop that maintained the T.

    AI such as exe also lead to massive increases in blood androgens simply due to blocking the E2 plug on the testes

    DHT can hit estrogen beta (the good estrogen IMO) though which im thinking could be a potential negative feedback mechanism, DHT cream can suppress T

    Mesterelone is a diff compound as you mention tho
     
  8. Kunstruct

    Kunstruct Member

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    Yes Mesterolone is not DHT like people claim.
    We are talking about a drug invented in 1934 which is even before Testosterone Propionate 1937.
     
  9. Kunstruct

    Kunstruct Member

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    50mg to 100mg, 2 or 3 times per day is the regular dose according to some doctors, so 75mg to 150mg is not massive. And Proviron is nothing physiological, it is not DHT.
     
  10. TheBeard

    TheBeard Member

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    Exactly
     
  11. tankasnowgod

    tankasnowgod Member

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    Except it's based on DHT, and has similar action to DHT, similar to how most anabolic steroids aren't testosterone, but are based on testosterone, and have similar functioning in the body.
     
  12. tankasnowgod

    tankasnowgod Member

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    Just because something is a "regular dose" according to some, or even most, doctors, does not mean it's not a massive or problematic dose. That's discussed all the time on this forum, from "treatments" like chemotherapy to lab ranges for ferritin.
     
  13. OP
    André Luiz

    André Luiz Member

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    But if it reduced shbg bound T the total T should have increased, right?
     
  14. Kingpinguin

    Kingpinguin Member

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    SHBG would likely free up more free T. Thats usually what you see in mesterolone studies. SHBG bound Testosterone is included in the term total testosterone. That why they say free T. So if you lower shbg bound T you would lower total T. Why free T stayed the same i’m not sure. If they measure estrogen and DHT aswell it would be interesting to see how much if the new free T got converted to those steroids. But if LH stays the same its indicative that it does not cause supression at the dose they used. Thats what steroids do. They stimulate the feedback to shut off endogenous production. Anabolic steroids are more potent at this and androgenic is not. Likely because they don’t convert to estrogen. Estrogen is much more potent at turning off LH production. And mesterolone cant convert to estrogen so it does not do that. While most steroid juicers use high doses of testosterone where a big part of it gets converted to estrogen thus shutting them down hard. That why you use AIs and SERMs post cycle to get your own T synthesis going. Its all about blocking estrogens suppressive effect on the pituitary. Thats how clomid work.
     
  15. OP
    André Luiz

    André Luiz Member

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    Thanks for answering
    Juste found a study made with halotestin, it strongly supressed T but did not affected LH
    The effects of fluoxymesterone administration on testicular function. - PubMed - NCBI
    I wonder if proviron doesnt do the same? After all the reduction caused by proviron is also very significant and the free T was unchanged...
     
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