AlphaCog
Member
- Joined
- Jan 28, 2014
- Messages
- 90
Prolonged Intake of Coenzyme Q10 Impairs Cognitive Functions in Mice
"Mice were fed a control nonpurified diet or that diet containing 0.68 mg/g (low dosage) or 2.6 mg/g (high dosage) CoQ10, starting at 4 mo of age, and were tested for sensory, motor, and cognitive function at 7, 15, and 25 mo of age. Amounts of the ubiquinols CoQ9H2 and CoQ10H2 measured in a parallel study were augmented in the cerebral cortex but not in any other region of the brain. Intake of the low-CoQ10 diet did not affect age-associated decrements in muscle strength, balance, coordinated running, or learning/memory, whereas intake at the higher amount increased spontaneous activity, worsened the age-related losses in acuity to auditory and shock stimuli, and impaired the spatial learning/memory of old mice."
"In summary, our present findings accord with those reported previously in that CoQ10 administration during adult life does not extend the life span of rodents (26,49,50). Although prolonged CoQ10 intake in low amounts did not have a discernable effect on cognitive and motor functions, intake at higher amounts exacerbated some of the cognitive and sensory impairments encountered in aged mice. Thus, regardless of whether CoQ10 ultimately proves to be ameliorative in specific disease conditions involving oxidative stress and/or mitochondrial dysfunctions, the current findings tend to controvert the view that CoQ plays a direct or significant role in the mammalian aging process and is a credible antiaging intervention."
"Mice were fed a control nonpurified diet or that diet containing 0.68 mg/g (low dosage) or 2.6 mg/g (high dosage) CoQ10, starting at 4 mo of age, and were tested for sensory, motor, and cognitive function at 7, 15, and 25 mo of age. Amounts of the ubiquinols CoQ9H2 and CoQ10H2 measured in a parallel study were augmented in the cerebral cortex but not in any other region of the brain. Intake of the low-CoQ10 diet did not affect age-associated decrements in muscle strength, balance, coordinated running, or learning/memory, whereas intake at the higher amount increased spontaneous activity, worsened the age-related losses in acuity to auditory and shock stimuli, and impaired the spatial learning/memory of old mice."
"In summary, our present findings accord with those reported previously in that CoQ10 administration during adult life does not extend the life span of rodents (26,49,50). Although prolonged CoQ10 intake in low amounts did not have a discernable effect on cognitive and motor functions, intake at higher amounts exacerbated some of the cognitive and sensory impairments encountered in aged mice. Thus, regardless of whether CoQ10 ultimately proves to be ameliorative in specific disease conditions involving oxidative stress and/or mitochondrial dysfunctions, the current findings tend to controvert the view that CoQ plays a direct or significant role in the mammalian aging process and is a credible antiaging intervention."