Adrenaline
Member
- Joined
- Sep 9, 2019
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- 96
As you know Aldosterone, Angiotensin II and Calcium Channels are major contributors of hypertension and related heart diseases. This study shows that prolactin increases both aldosterone and angiotensin through to T-Type Calcium Channels.
Stimulatory Effects of Hyperprolactinemia on Aldosterone Secretion in Ovariectomized Rats
CONCLUSIONS: These results suggest that hyperprolactinemia increases basal, angiotensin II- and KCl-stimulated aldosterone secretion by ZG cells in OVX rats through activation of T-type Ca2+ channels, the post-cAMP and protein kinase A pathway, cytochrome P450 side-chain cleavage enzyme, and aldosterone synthase, as well as by causing increased expression of steroidogenic acute regulatory protein in ZG cells.
Stimulatory Effects of Hyperprolactinemia on Aldosterone Secretion in Ovariectomized Rats
CONCLUSIONS: These results suggest that hyperprolactinemia increases basal, angiotensin II- and KCl-stimulated aldosterone secretion by ZG cells in OVX rats through activation of T-type Ca2+ channels, the post-cAMP and protein kinase A pathway, cytochrome P450 side-chain cleavage enzyme, and aldosterone synthase, as well as by causing increased expression of steroidogenic acute regulatory protein in ZG cells.