Progesterone Lowers SHBG

[Nick Ireland]

This is a first in my research of experience of endocrine hormones. High SHBG may limit the expression of testosterone and dht. Drugs like Danazol and Winstrol can dramatically lower it, but the body usually responds by lowering T production - so a goal of increasing T by this mono therapy is very difficult. Shbg can rise for many reasons including inflammation and higher levels of estrogen.
But what if a novel treatment with Progesterone may treat symptoms AND cause? We already know P can increase T in males, lower and block E and treat inflammation. Now it appears to suppress SHBG expression:

http://www.ncbi.nlm.nih.gov/m/pubmed/9408086/

 

[timr]

Has anyone tried this protocol?

 

[Drareg]

T3 raises it?
If your already high on shbg while taking dhea,this may just leave dhea in the system with no conversions, dhea is not effected by shbg?

 

[Progesterone]

What is this subject headline????

All research shows Progesterone to INCREASE SHBG....

 

[Such_Saturation]

You can't make this stuff up lmao

 

[Progesterone]

View attachment 8020

View attachment 8021 You can't make this stuff up lmao

Not sure why someone made the subject 'Prog lowers SHBG'. I was searching specifically for Prog & SHBG. I don't know why OP seems to think it lowers SHBG, even with the link he posted... very odd.

 

[ddjd]

This is a first in my research of experience of endocrine hormones. High SHBG may limit the expression of testosterone and dht. Drugs like Danazol and Winstrol can dramatically lower it, but the body usually responds by lowering T production - so a goal of increasing T by this mono therapy is very difficult. Shbg can rise for many reasons including inflammation and higher levels of estrogen.
But what if a novel treatment with Progesterone may treat symptoms AND cause? We already know P can increase T in males, lower and block E and treat inflammation. Now it appears to suppress SHBG expression:

http://www.ncbi.nlm.nih.gov/m/pubmed/9408086/

what? these quotes dont make sense then...

Haidut: SHBG goes up and down together with estrogen.

Ray: SHBG should be as high as possible to keep estrogen out of cells, and that it actually enters cells when it is unloaded, unlike albumin.