Progesterone Is Anti-Fibrotic

[LCohen]

Effect of progesterone on Smad signaling and TGF-β/Smad-regulated genes in lung epithelial cells. - PubMed - NCBI

...While progesterone alone had no direct effect on Smad signaling in lung epithelial cells, it dose-dependently inhibited TGF-β1-induced Smad3 phosphorylation, as shown by luciferase assays and western blotting analysis. Progesterone also antagonized the TGF-β1/Smad-induced upregulation of CTGF, transgelin, and PAI-1 at the promoter, mRNA, and/or protein levels...

 

[aguilaroja]

Progesterone also antagonized the TGF-β1/Smad-induced upregulation of CTGF, transgelin, and PAI-1 at the promoter, mRNA, and/or protein levels...

Many thanks. Hopefully, there will be further investigation about the anti-fibrotic, restorative function of progesterone. Perhaps lack of commerce incentive has slowed this research previously.

Progesterone ameliorates diabetic nephropathy in streptozotocin-induced diabetic Rats
“…replacement of progesterone can ameliorate the renal damage in the experimental models of diabetic nephropathy through improving the renal function; the inhibition of renal fibrosis and abnormal angiogenesis; along with the amelioration of podocyte injury.”

Effects of hyperprolactinemia on the tibial epiphyseal plate of mice treated with sex hormones. - PubMed - NCBI
“These findings suggest that oophorectomy and hyperprolactinemia changed epiphyseal plate morphology causing cartilage degeneration.”