Progesterone And Serotonin

[Lucas]

Hello.

I had a blood test in May 2015 whit Serotonin at 367,4 ng/ml . This was when I was taking thyroid NDT whit a TSH of 0,015.

In October my serotonin was 206,6 ng/ml. This time my TSH raised to 4,8.

But now, my serotonin comes at 56,1 ng/ml, whit a TSH at 0,27 whit T4 and T3 use.

The only difference on this last blood test Is I was taking 50 mg of progesterone.

So, progesterone lowered my serotonin?

 

[dookie]

Hello.

I had a blood test in May 2015 whit Serotonin at 367,4 ng/ml . This was when I was taking thyroid NDT whit a TSH of 0,015.

In October my serotonin was 206,6 ng/ml. This time my TSH raised to 4,8.

But now, my serotonin comes at 56,1 ng/ml, whit a TSH at 0,27 whit T4 and T3 use.

The only difference on this last blood test Is I was taking 50 mg of progesterone.

So, progesterone lowered my serotonin?

This is very interesting, thanks for posting.

I have found some overlapping effects between Progesterone and Cyproheptadine, so I strongly believe that progesterone lowers serotonin, and probably also lowers histamine (it seems to have some anti-allergy effects).

Unfortunately, progesterone greatly increases estrogen in myself. Are you male? Have you experienced estrogenic effects from the progesterone?

 

[ecstatichamster]

How were you taking the progesterone?

 

[Lucas]

Orally 50 mg at bed time. It was bioidentical progesterone

 

[DaveFoster]

That's an amazing drop. I can see why progesterone would have that effect, as it's calming.

 

[ddjd]

can progesterone lower serotonin? any studies?

 

[ddjd]

post from haidut on the issue

Progesterone, Testosterone, Allopregnanolone Are Serotonin Antagonists

 

[ddjd]

These other articles tend to show lower serotonin and TPH2 with [presumably] natural progesterone

Estrogen selectively increases tryptophan hydroxylase-2 mRNA expression in distinct subregions of rat midbrain raphe nucleus: association between g... - PubMed - NCBI

In vivo evidence for progesterone dependent decreases in serotonin release in the hypothalamus and midbrain central grey: relation to the induction... - PubMed - NCBI

Differences in hypothalamic serotonin between estrous phases and gender: an in vivo microdialysis study. - PubMed - NCBI

Estrous cycle modulation of extracellular serotonin in mediobasal hypothalamus: role of the serotonin transporter and terminal autoreceptors. - PubMed - NCBI