Progestene - Liquid Progesterone (bioidentical)

[yerrag]

In my experience, combining progesterone with a little DHEA has a much more potent effects on improving heart rate than progesterone alone. Also, DHEA was shown to lower blood pressure in several animal studies and this also allows the heart to work with less strain. As most elevated BP is due to stiff vessels, and the stiffness is due to elevated cortisol (and low pregnenolone/progesterone/DHEA) this makes sense. DHEA also has positive inotropic effects on heart and has been proposed as heart failure treatment.
NYAS Publications
"...Of clinical interest, DHEA stimulates hepatic sulfotransferases, enzymes which sulfate steroids, and this effect may be applicable to sulfation and the solubility of bile acids.6h Effects on cardiac inotropic response suggest that DHEA and its analogs should be looked at in heart failure, as substitutes for or adjuncts to digitalis[67]."

Thanks, I'll try progesterone with DHEA next time. I suppose it wouldn't hurt to have pregnenolone in the mix as I have Pansterone for the DHEA.

 

[yerrag]

I've been using this for the past 3 day 3 x 20mg for it to deactivate endotoxins. It didn't change my temperature, unlike the incident I had in May when I applied 30mg in the span of two hours in the morning, only to feel my temperature rise to 38 at night, and then I felt the chills and wrapped myself in blanket to sleep.

But I noticed that my heart rate went down greatly to a range of 50-68 throughout the day, as compared to the range of 56- 79 the day before I started using progestene. I continue to use this for the next 2 days, continuing even now, as I tried to make sense of it. I had the impression that Progestene is a metabolic booster, as I'd seen the heart rate of my mom increase after application. I also experienced higher heart rate in the past, or so I thought. I couldn't be sure though, as I may have experienced a higher heart rate/base- from another substance, and so the higher heart rate may not be due to the use of Progestene.

But seeing my heart rate drop so much using this much Progestene made me concerned. Was my metabolism going down? I tested my temperature and it hasn't changed from the norm of 36.5 -37C though, but I was still concerned. Had to read up on Peat's website, and as I look at this article Heart and hormones , I thought maybe it's just the inotropic action of progesterone, that :

Another standard term describing heart function is chronotropy, referring to the frequency of contraction. Because of the staircase interaction of frequency and force, there has been some confusion in classifying drugs according to chronotropism. In a state of shock or estrogen dominance, an inotropic drug will slow the heart rate by increasing the amount of blood pumped. This relationship caused digitalis' effect to be thought of as primarily slowing the rate of contraction (Willins and Keys, 1941), though its main effect is positively inotropic. It was traditionally used to treat edema, by stimulating diuresis, which is largely the result of its inotropic action. Progesterone and testosterone's inotropic action can also slow the heart beat by strengthening it.
​

Until I personally experience what Ray Peat's saying, it's really hard to understand what he's saying as now I can appreciate the meaning in an article I've read a few times and couldn't really internalize.

My heart rate is now 68. Given the inotropic effect of progesterone at work, should I be seeing this heart rate as the "true" heart rate I should be using as a basis for the soundness of my metabolism? Does this mean the higher rates I've recorded in the past are reflective more of the inefficiency of the pump called the heart, due to various issues such as acid-base balance, calcium/electrolyte imbalance, calcification in the mitral valve causing "leaks?"

Would it make sense, if one were to get a better basis for one's metabolic rate, to first take progesterone in sufficient quantity, to get into this sweet spot of chronotropy, so that the subsequent measurement of the heart rate would reflect the true heart rate?

I realize now that what I felt was progesterone lowering my heart rate to such extent may just be just my lack of thiamine.

I had been urinating a lot, and this robbed me of thiamine and potassium. Once I began to take them, my heart rate improved.

 

[Momado965]

@haidut For hair regrowth and thinkinging what hormones of the following: t3, keto dht, progesterne, or keto progesterone whould you suggest works best either alone or in combination topically on scalp?

 

[encerent]

can we can an option for mct/tocopherals as the solvent for this?

 

[Ania]

@haidut, do you think it is a good idea to add a drop or two to the face cream at night for anti wrinkle effect?

 

[Stramonium]

Is topical administration of Progestene more likely to be converted into androgens?

 

[Waynish]

A female friend of mine tried progesterone on three separate occasions (one was separate about 1.5 years). She is always upbeat, but found herself crying for reasons she didn't understand within about 30 minutes on each occasion (of 1 drop of progestene). This sounds like the mainstream description of progesterone's action... Thoughts?

 

[opethfeldt]

A female friend of mine tried progesterone on three separate occasions (one was separate about 1.5 years). She is always upbeat, but found herself crying for reasons she didn't understand within about 30 minutes on each occasion (of 1 drop of progestene). This sounds like the mainstream description of progesterone's action... Thoughts?

Lowering of prolactin I'm guessing. Prolactin is eliminated in tears.

 

[boris]

A female friend of mine tried progesterone on three separate occasions (one was separate about 1.5 years). She is always upbeat, but found herself crying for reasons she didn't understand within about 30 minutes on each occasion (of 1 drop of progestene). This sounds like the mainstream description of progesterone's action... Thoughts?

Peat commented on negative progesterone effects that circulate on the internet. Some women have such high estrogen levels that low dose progesterone can have a bad effect.

In that case he recommends about a quarter teaspoon single dose. And the following days the regular dose.

 

[Soren]

Oral dose of 15mg is making subject very sleepy. Any suggestions? Greatly reduces her anxiety but basically knocks her out.

Anyone have any idea as to how to counter this?

 

[Gone Peating]

Oral dose of 15mg is making subject very sleepy. Any suggestions? Greatly reduces her anxiety but basically knocks her out.

Anyone have any idea as to how to counter this?

Try less

 

[Soren]

Try less

Yea I originally started her on a much lower dose of only 5mg but it did not seem to have much of a beneficial effect on her anxiety. She suffers from Parkinson's disease and my theory is that her body is running on stress hormones to get by mainly cortisol.

She said that after taking it she felt a lot more relaxed but as if she had no energy or strength in her body. My theory is that she is relying on stress hormones for energy so as soon as those stress hormones are taken away she immediately feels exhausted. I've told her that this may be unavoidable in many ways while her body starts to repair itself.

Tried giving her energin yesterday along with the progesterone but this made her very jittery and increased her tremors. The key is restoring her oxidative metabolism so she is not relying on here body's stress hormones and one of the ways to do this is obviously reducing cortisol but this also has the unwanted sedative side-effect.

 

[Gone Peating]

Yea I originally started her on a much lower dose of only 5mg but it did not seem to have much of a beneficial effect on her anxiety. She suffers from Parkinson's disease and my theory is that her body is running on stress hormones to get by mainly cortisol.

She said that after taking it she felt a lot more relaxed but as if she had no energy or strength in her body. My theory is that she is relying on stress hormones for energy so as soon as those stress hormones are taken away she immediately feels exhausted. I've told her that this may be unavoidable in many ways while her body starts to repair itself.

Tried giving her energin yesterday along with the progesterone but this made her very jittery and increased her tremors. The key is restoring her oxidative metabolism so she is not relying on here body's stress hormones and one of the ways to do this is obviously reducing cortisol but this also has the unwanted sedative side-effect.

She probably needs a lot more food than she normally eats. Try giving her some soda or other sugar dense foods to snack on in addition to what she usually eats

 

[Soren]

She probably needs a lot more food than she normally eats. Try giving her some soda or other sugar dense foods to snack on in addition to what she usually eats

I tend to agree. Getting her to eat sufficient sugar and calories is the most difficult part. I also think there is an issue where her liver is not functioning very well so it is not storing glycogen. She drinks very rarely and If she has just two glasses of wine she really feels the alcohol.

 

[Yure]

@haidut What's the concentration (mg/mL) of DMSO in this product?

 

[johnwester130]

I no longer use onasnatural 10% progesterone in vitamin E

I was getting a nasty feeling in my stomach from it. Maybe the vitamin E or the MCT oil can be irritating and I just felt unwell.
I react much much better to alcohol based supplements.

 

[johnwester130]

@haidut What's the concentration (mg/mL) of DMSO in this product?

hello

he no longer uses DMSO since last year

This is dissolved in alcohol solution/ester

 

[Progesterone]

I no longer use onasnatural 10% progesterone in vitamin E

I was getting a nasty feeling in my stomach from it. Maybe the vitamin E or the MCT oil can be irritating and I just felt unwell.
I react much much better to alcohol based supplements.

Do you feel the ona's is legit?

Which batch do you have?

I have 2 batches:

in one, the bottle tinted dark, this batch seems good... almost no taste.

in an older batch, the progesterone tastes quite strongly... and the bottle is not tinted at all, prog looks orange.

 

[johnwester130]

Do you feel the ona's is legit?

Which batch do you have?

I have 2 batches:

in one, the bottle tinted dark, this batch seems good... almost no taste.

in an older batch, the progesterone tastes quite strongly... and the bottle is not tinted at all, prog looks orange.

the bottle is clear. tastes kinda rancid to be honest.
this looked like dark honey from the vitamin E it was dissolved in.

I don't know if it is legit.
Sometimes I just felt nothing from it.


Ingredient Facts

• 10% Natural USP Progesterone.
• Natural Vitamin E (Tocopherol) derived from soy oil - Provides many health benefits for the skin as a strong Vitamin E cream.
• FCO Coconut oil.

 

[Progesterone]

the bottle is clear. tastes kinda rancid to be honest.
this looked like dark honey from the vitamin E it was dissolved in.

I don't know if it is legit.
Sometimes I just felt nothing from it.


Ingredient Facts

• 10% Natural USP Progesterone.
• Natural Vitamin E (Tocopherol) derived from soy oil - Provides many health benefits for the skin as a strong Vitamin E cream.
• FCO Coconut oil.

Yeah... you got that one a while ago huh?

I don't know if that one is legit... but the most recent batch I received seems to be legit.

Health natura is more trusted, however is very expensive, unfortunately.