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Thank you for this information. I try to research things but with such fatigue I'm limited. I've started taking nicinamide from pure bulk . I've started with low doses to start. I will look for studies on nicinamide and cfs to find a dosage.As far as I've researched, you want to have a high NAD:NADH ratio, not the other way around. Diseased tissues typically have low NAD:NADH. So supplementing NADH would worsen the ratio, although I'm not sure if there would be some therapeutically reason to push the ratio towards NADH. Niacinamide provides a lot of NAD, and some of that NAD gets converted to NADH.
I totally understand, I've been there... hope you find something that helpsI try to research things but with such fatigue I'm limited.