Procaine And Its Metabolites Increase CoA And Acetyl-coA Concentration In Various Tissues In Rats

raypeatclips

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I don't fully understand this one but it looks interesting and perhaps someone more knowledgeable would be able to explain it below?

Z Alternsforsch. 1989 Jul-Aug;44(4):211-7.
[Effect of procaine and procaine metabolites on coenzyme A and acetyl coenzyme A concentration in various tissues of the rat].
[Article in German]
Kietzmann M1, Kaemmerer K.

Abstract
In rats treated with procaine hydrochloride, diethylaminoethanol, monoethylaminoethanol, ethanolamine, as well as a combination of procaine hydrochloride and haematoporphyrine the ratio of acetyl coenzyme A and coenzyme A clearly was enhanced in the liver and to a minor extent in the cerebellum. In the tissue of cerebral cortex, heart, muscle and duodenum no corresponding effects were demonstrated. These findings, showing a further intermediary effect of orally administered procaine, can be interpreted as an influence in intermediary energy utilisation.
 
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