Rafael Lao Wai
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There was one study about excessive salt in the diet being soaked up by organs, especially skin. In the study, they said the excess sodium could be held in the skin without causing edema as osmotically inactive, by binding to these glycosaminoglycans. Since manganese can increase the amount of these substances, could it help to explain in part of the reason why some people can avoid increases in blood pressure after a big salt dose, while others get high blood pressure?"One significant function of Mn is its effect on proteoglycan (PG) and glycosaminoglycan (GAG) metabolism (Leach 1971). Manganese functions as a specific activator of glycosyltransferases, enzymes involved in the elongation and polymerization of GAG chains in connective tissue (Leach et al. 1969). Manganese deficiency affects GAGs biosynthesis and results in decreases in total and individual GAGs, especially chondroitin sulfate (CS) in chick cartilage and rat skin (Leach et al. 1969; Bolze et al. 1985; Leach 1986; Shetlar & Shetlar 1994). Manganese also effectively activates sulfotransferases, enzymes involved in GAG sulfation and synthesis (Gundlach & Conrad 1985)."
It's worth observing if having adequate manganese makes a difference on how sulfate is metabolized. Manganese follows (for the most part) the fat-soluble route of excretion through feces, whereas sulfate is eliminated mainly in urine, like other water-soluble toxins. If sulfate is applied on the skin at the same time that a meal rich in manganese is consumed, by the time that it gets digested, sulfate may already be on its way out.