tankasnowgod
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- Joined
- Jan 25, 2014
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One of the ideas of Ray Peat's that seems to run counter to both the mainstream and alternative health world is that bacteria in the GI tract is NOT beneficial, in general. Peat has said that there are some strains of bacteria that are less harmful than others, and even can produce some beneficial substances, but that all bacteria produce negative products as well, like lactic acid and endotoxin.
In another thread, I heard this quote, where Peat speaks favorably of Lactobacillus-
Of course, the thing that stuck out to me is that Lactobacillus is anti-inflammatory, EVEN IF IT'S DEAD! Well, looking around a bit, there is at least a little interest in using dead lactobacillis in people who have digestive issues-
Probiotics: Better off dead?
"Joseph Neu of the University of Florida School of Medicine and his colleagues reviewed several studies that compared health impacts using live microbes versus those that had first been killed by heat or ultraviolet radiation. The dead bugs were just as effective as live ones, they report, but “considerably safer for the host.” For instance, they appeared less likely to provoke an overzealous immune response.
One study worked with Lactobacillus rhamnosus GG, better known as LGG. Researchers administered high doses of the bacterial strain to human cells that normally line the interior surface of the gut. When stimulated in a way that simulated the presence of a pathogen, the gut cells revved up a bigger inflammatory response than when the probiotics were absent. Both live and dead LGG induced fairly comparable responses — ones that would be expected to improve the gut’s ability to fight infection."
https://www.tandfonline.com/doi/abs/10.1080/07315724.2000.10718084
"A number of studies using animal models and clinical studies in humans have confirmed the beneficial effect of such fermented products in case of lactose intolerance, viral diarrhea or antibiotics-associated diarrhea. The mechanisms by which lactic acid bacteria exert their effects are multiple. Bacterial lactase improves the absorption of lactose, but fermented products slow down the intestinal transit facilitating the action of residual intestinal lactase. The transient passage of lactic acid bacteria in the digestive tract may represent a microbial barrier against the development of pathogenic bacteria, probably due to the release of compounds contributing to the maintenance of colonization resistance to pathogens. The beneficial effects are mainly described in the presence of live bacteria, but inactivated bacteria may also present preventive or curative capacities in diarrheal diseases. "
I remember from my paleo days that the big "complaint" with probiotic products was that the species were dead and inactive. Far from being a problem, this may have actually been a benefit, and in many species, wouldn't have prevented beneficial effects, and may have contained negatives, such as lactic acid production.
Heat, UV Light, and stomach acid are all things that can help to kill probiotics. So, maybe there is benefit to getting some of the cheap, non-enteric coated lactobacillis products, not keeping them in the fridge, exposing to light, and taking either with a hot substance like coffee, or along with digestive enzymes.
Thoughts? And does anyone know of a product that sells dead or "inactivated" Lactobacillus?
In another thread, I heard this quote, where Peat speaks favorably of Lactobacillus-
Of course, the thing that stuck out to me is that Lactobacillus is anti-inflammatory, EVEN IF IT'S DEAD! Well, looking around a bit, there is at least a little interest in using dead lactobacillis in people who have digestive issues-
Probiotics: Better off dead?
"Joseph Neu of the University of Florida School of Medicine and his colleagues reviewed several studies that compared health impacts using live microbes versus those that had first been killed by heat or ultraviolet radiation. The dead bugs were just as effective as live ones, they report, but “considerably safer for the host.” For instance, they appeared less likely to provoke an overzealous immune response.
One study worked with Lactobacillus rhamnosus GG, better known as LGG. Researchers administered high doses of the bacterial strain to human cells that normally line the interior surface of the gut. When stimulated in a way that simulated the presence of a pathogen, the gut cells revved up a bigger inflammatory response than when the probiotics were absent. Both live and dead LGG induced fairly comparable responses — ones that would be expected to improve the gut’s ability to fight infection."
https://www.tandfonline.com/doi/abs/10.1080/07315724.2000.10718084
"A number of studies using animal models and clinical studies in humans have confirmed the beneficial effect of such fermented products in case of lactose intolerance, viral diarrhea or antibiotics-associated diarrhea. The mechanisms by which lactic acid bacteria exert their effects are multiple. Bacterial lactase improves the absorption of lactose, but fermented products slow down the intestinal transit facilitating the action of residual intestinal lactase. The transient passage of lactic acid bacteria in the digestive tract may represent a microbial barrier against the development of pathogenic bacteria, probably due to the release of compounds contributing to the maintenance of colonization resistance to pathogens. The beneficial effects are mainly described in the presence of live bacteria, but inactivated bacteria may also present preventive or curative capacities in diarrheal diseases. "
I remember from my paleo days that the big "complaint" with probiotic products was that the species were dead and inactive. Far from being a problem, this may have actually been a benefit, and in many species, wouldn't have prevented beneficial effects, and may have contained negatives, such as lactic acid production.
Heat, UV Light, and stomach acid are all things that can help to kill probiotics. So, maybe there is benefit to getting some of the cheap, non-enteric coated lactobacillis products, not keeping them in the fridge, exposing to light, and taking either with a hot substance like coffee, or along with digestive enzymes.
Thoughts? And does anyone know of a product that sells dead or "inactivated" Lactobacillus?
