Prevention of paracetamol-induced liver injury by fructose

Edward

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Prevention of paracetamol-induced liver injury by fructose
http://www.sciencedirect.com/science/ar ... 529190121K

Hepatic cell injury was studied in an in vitro system using rat liver slices incubated in two stages. During the first 2 hr slices were exposed to 10 mM paracetamol, this was absent during the subsequent 4hr of incubation. Cell damage was quantified at the end by measuring leakage of lactic dehydrogenase, increase in water content and potassium loss. Treatment of slices with 20 mM fructose in the second period of incubation prevented paracetamol-induced damage. The effect of fructose was not modified by the continued presence of paracetamol in the second incubation period. The inhibition of glycolysis either with 1 mM NaF or 10 μM iodoacetate blocked the effect of fructose. The protective effect afforded by fructose was not duplicated by the addition of lactate. All these findings strongly suggest an increase in intracellular ATP levels as the most probable explanation for the protective effect of fructose, and point to fructose as a potentially useful therapeutic tool for protection of the liver late in paracetamol intoxication.
 

burtlancast

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Re: Prevention of paracetamol-induced liver injury by fructo

:hattip

Quite interesting.

Peat already explained fructose helps diabetics metabolise glucose. Paracetamol induced liver poisonning is an extremely prevalent cause for liver failure/ transplants, especially amongst Crohn and ulcerative colitis people. All it takes is to take more than 4 pills/ day.
 

Edward

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Re: Prevention of paracetamol-induced liver injury by fructo

burtlancast said:
:hattip

Quite interesting.

Peat already explained fructose helps diabetics metabolise glucose. Paracetamol induced liver poisonning is an extremely prevalent cause for liver failure/ transplants, especially amongst Crohn and ulcerative colitis people. All it takes is to take more than 4 pills/ day.

What is worse is parents who feed their children paracetamol for every ache and pain. I can only suspect what the long term consequences are plus poor eating habits. I've seen some parents dose their children with paracetamol before getting a vaccination to prevent symptoms from the vaccination!
 
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