Premature Ejaculation Is Ruining My Life

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How rapid would the effects take place? Could be problematic with condom use, however. I'd imagine it could lead to breakage.

I remember reading some study somewhere claiming men that had higher progesterone lasted longer than average during intercourse.

There might be a cumulative effect of using progesterone topically over time that could help with PE.

Thought methylene blue might've been a candidate but on a little over 1mg a day I haven't noticed any marked improvements. Not gonna write it off completely though. Haven't had many opportunities to see if it's helping much, to be fair.

I find progesterone + DHEA very useful. I don't put it on my penis, unless there is a reason to.
 

Jib

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A new potential risk factor in patients with erectile dysfunction and premature ejaculation: folate deficiency

I became interested in methylfolate after being diagnosed with the C677T and A1298 MTHFR genetic mutations. Perhaps I'll start taking it again. I do think it's important to consider the methylation cycle as a whole and perhaps not just focus on folate alone, although it is an important part of the puzzle. The stuff I have is pretty high potency (15mg), so I'll probably break them up.

Though I remember my doctor telling me that in the studies he looked at, 15mg methylfolate was the effective dose for major depression. I haven't read enough to understand the safety of taking such a high dose but I also don't remember coming across anything alarming implying it could do much harm. I think it's worth experimenting with at least a moderate dose.
 

Frankdee20

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A new potential risk factor in patients with erectile dysfunction and premature ejaculation: folate deficiency

I became interested in methylfolate after being diagnosed with the C677T and A1298 MTHFR genetic mutations. Perhaps I'll start taking it again. I do think it's important to consider the methylation cycle as a whole and perhaps not just focus on folate alone, although it is an important part of the puzzle. The stuff I have is pretty high potency (15mg), so I'll probably break them up.

Though I remember my doctor telling me that in the studies he looked at, 15mg methylfolate was the effective dose for major depression. I haven't read enough to understand the safety of taking such a high dose but I also don't remember coming across anything alarming implying it could do much harm. I think it's worth experimenting with at least a moderate dose.

That’s a very high dose, and the reason he suggested that is because it’s a prescription medication at that dose....
 

Jib

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That’s a very high dose, and the reason he suggested that is because it’s a prescription medication at that dose....

That's what I figured.

High dose thiamine has shown promise for lots of conditions, so I won't write off high dose methylfolate. But the question is what exactly it does in extremely super-normal amounts. A question I don't have the answer to.

For long-term supplementation I would stick closer to 1mg - 2mg. Chris Masterjohn has an interesting article about MTHFR mutations:

Start Here for MTHFR and Methylation

People wanting to throw massive doses of folate at the problem are likely misguided...or selling you something.

It does make me wonder if supplements that can support methylation (creatine and glycine, for example) may also potentially help premature ejaculation. The simple explanation would be that the sympathetic nervous system is too active and too sensitive in men with PE. Erections are a function of the parasympathetic nervous system; ejaculation, the sympathetic nervous system.

Anything that supports metabolism and suppresses stress hormone production should be helpful. At least in the case of people with MTHFR mutations, things like creatine and glycine may be of great help. I'm also a big fan of taurine and beta-alanine.

The psychological aspect is particularly interesting to me, having some background in NLP. But it could be that the lack of control and racing sexual thoughts is a result of the sympathetic nervous system being overstimulated and overactive.
 

Frankdee20

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That's what I figured.

High dose thiamine has shown promise for lots of conditions, so I won't write off high dose methylfolate. But the question is what exactly it does in extremely super-normal amounts. A question I don't have the answer to.

For long-term supplementation I would stick closer to 1mg - 2mg. Chris Masterjohn has an interesting article about MTHFR mutations:

Start Here for MTHFR and Methylation

People wanting to throw massive doses of folate at the problem are likely misguided...or selling you something.

It does make me wonder if supplements that can support methylation (creatine and glycine, for example) may also potentially help premature ejaculation. The simple explanation would be that the sympathetic nervous system is too active and too sensitive in men with PE. Erections are a function of the parasympathetic nervous system; ejaculation, the sympathetic nervous system.

Anything that supports metabolism and suppresses stress hormone production should be helpful. At least in the case of people with MTHFR mutations, things like creatine and glycine may be of great help. I'm also a big fan of taurine and beta-alanine.

The psychological aspect is particularly interesting to me, having some background in NLP. But it could be that the lack of control and racing sexual thoughts is a result of the sympathetic nervous system being overstimulated and overactive.


The only thing I’ve read on this subject that is relevant to Folate and your Methylation references is basically Histamine.... PE has been purported to be caused by high histamine, and methylfolate (not folic acid) helps lower histamine levels via methyl donors.... I don’t know honestly because I’ve never tried such doses.....
 

Frankdee20

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Foreplay / oral sex. Satisfy her needs first - then the rapid release is not a big issue.

Yeah that’s warranted, but I guarantee he is not enjoying sexual intercourse... How can you when you don’t even get into a rhythm
 

Frankdee20

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By the way, Folic Acid will not do the same thing as Methylfolate when it comes to Histamine....
 

Frankdee20

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I think SSRIs work not because of the increase in serotonin but because of the desensitization of the serotonin receptor, because I have found anything that increases serotonin does terribly for me for how long I last

Lisuride increased lasting time for me by a huge amount when I tried it. Dopamine dopamine dopamine

Yeah but Lisuride likely helped via serotonin receptors, specifically 5HT2C agonism.
 

Frankdee20

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PE has been linked to increased 1A and 2B activity and low 2C activity on 5HT circuits... Good reports of using Pindolol (beta blocker with 5HT1A antagonist properties)... You can try that approach or use condoms with the numbing agents in them already.... Durex and Trojan make them
 

pro marker

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As a bit of back-round, i started masturbating from a young age and i would literally get myself to climax VERY quick maybe 10 seconds using a death grip, i would purposely do it very quick and on a consistent basis too, so i've probably got a few years of reversing to do. if i rememeber rightly and i'm not sure if this was before or after i started masturbating but i would get to orgasm feeling (without any ejaculation at that age) By even just swimming?! So if this was before masturbating maybe i had some issue from birth?

Anyhow these days a few full pumps into a women like 2-3 and i'm gone (sometimes 1). It's absolutely humiliating. I'm very much into meditation and getting into the body, being present, taking deep breaths but the sensitivity i have is absolutely overwhelming and i dont think anyone could control it by taking deep breaths.

I was thinking a numbing spray, does anyone have any recommendations for 'safer' ones or do they all have side effects?

i used to be able hold it as long as i wanted but after peating that is no longer the case. i cum to early for my liking now. it doesnt ruin sex but it means i usually spend 5-10 minutes holding it in. heres my advice:

getting a partner is the best, you dont have to be so ashamed, you can talk about it and experiment. usually, the problem becomes better afer time with a partner.
quit porn.
masturbate less, but dont quit it completely. once or twice a week is probably fine.
find the position that you last the longest in, kinda obvious but a big factor. i cant even climax in missionary but when we do it doggy i have to look away and pray to god.
dont think about anything during the sex, try to clear your mind. if i start thinking about that one woman i slept with or how erotic the sex is i come quicker
breathe slowly and steadily. this one is important.
do it very slowly to being with
try not to look at her, steer your eyes away from her genitals.
instead do stupid unsexy things that women find sexy, like running your hands all over her back, running fingers through her hair, massaging her legs etc...
 

Frankdee20

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Combination Viagra and Dapoxetine pills help this condition as well as alpha antagonists like Silodosin
 

Ignoramus

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The based answer to this is that you're having sex with the wrong people. Be with someone who understands that you cum quick and is ok with it. Surely you last lnger on round 2?

I used to have this issue in my teens and early twenties. I think my PC muscle was too developed (I used to do the same thing as you when I was younger). What really helped me was figuring out to do 'reverse kegels' (where you push out and relax the PC muscle and anus; kinda like pushing a ***t out lol), and doing them during sex. You can practise masturbating while reverse kegeling; it will feel quite different.

Cypro makes me last as long as I want. I think the issue of PE is caused by high cortisol and sometimes by high estrogen. Also having a good workout before sex is great for PE issues.
 

MrGilbert

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In my experience a good workout routine and avoiding porn alleviates this issue. Do you regularly lift weights?
 

biomes

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Endotoxins in your gut are the cause of PE. Clear your gut of the excess endotoxins and you’ll notice PE is reduced. For example, try a carrot salad with coconut oil and you’ll feel the improvement. You can also flush out your endotoxins with high dose magnesium flushes (2 tbsp with water), coffee enemas, colonic hydrotherapy, etc.
 

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