I have been following this for some time now. The pharma industry is quickly running out of options for managing drug-resistant schizophrenia so it is turning to therapies from the beginning of the 20th century. Either way, if this makes it through the clinical trials it would be a huge win for Ray's ideas but bad news for us b/c I can guarantee you that pregnenolone's status as a dietary supplement will end the moment FDA realizes it works for a variety of "untreatable" brain conditions including all types of dementia (hint: AD) and psychiatric diseases.
http://www.sciencedirect.com/science/ar ... 0786X?np=y
http://www.ncbi.nlm.nih.gov/pubmed/24496044
http://www.ncbi.nlm.nih.gov/pubmed/23240026
The human studies used pregnenolone as adjunctive therapy and saw very positive results with the low dose of 50mg/day. The last study is a rodent study and used only pregnenolone, and it completely stopped the diseases. The human dosage equivalent from that study is 400mg-500mg per day. Though high, it is considered quite safe. Ray has taken 1g for extended period of time with no complaints and I have gone even higher with no side effects. The study I posted on pregnenolone's stimulatory effect on the thyroid used a human dose equivalent of 2.5g per day.
http://www.sciencedirect.com/science/ar ... 0786X?np=y
http://www.ncbi.nlm.nih.gov/pubmed/24496044
http://www.ncbi.nlm.nih.gov/pubmed/23240026
The human studies used pregnenolone as adjunctive therapy and saw very positive results with the low dose of 50mg/day. The last study is a rodent study and used only pregnenolone, and it completely stopped the diseases. The human dosage equivalent from that study is 400mg-500mg per day. Though high, it is considered quite safe. Ray has taken 1g for extended period of time with no complaints and I have gone even higher with no side effects. The study I posted on pregnenolone's stimulatory effect on the thyroid used a human dose equivalent of 2.5g per day.