It was recently discovered that the so-called TRM3 "receptors" in the pancreatic beta cells can be activated by pregnenolone sulfate (PS) at relatively low concentrations and result in insulin release. This makes pregnenolone a potential tool for keeping blood sugar levels normal and can also explain why some people experience nervoussness, cold extremeties, jitters, and headache from taking pregnenolone - i.e. it lowers your blood sugar.
Given the similar properties of taurine and glycine, I think a combination of pregnenolone and one of these (or both) aino acids can be a very effective way to maintain proper glucose homeostasis.
Btw, DHEA and DHEA-W had the same effect but were much less potent than PS.
TRPM3 - Wikipedia, the free encyclopedia
"...The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been -identified.[2] TRPM3 was shown to be activated by the neurosteroid pregnenolone sulphate in pancreatic beta cell. The activation causes calcium influx and subsequent insulin release, therefore it is suggested that TRPM3 modulates glucose homeostasis."
http://www.nature.com/ncb/journal/v10/n12/full/ncb1801.html
"...We show here that TRPM3, a divalent-permeable cation channel, is rapidly and reversibly activated by extracellular pregnenolone sulphate, a neuroactive steroid. We show that pregnenolone sulphate activates endogenous TRPM3 channels in insulin-producing β cells. Application of pregnenolone sulphate led to a rapid calcium influx and enhanced insulin secretion from pancreatic islets. Our results establish that TRPM3 is an essential component of an ionotropic steroid receptor enabling unanticipated crosstalk between steroidal and insulin-signalling endocrine systems."
"...We tested several other steroids, including substances with important genomic functions, and found that besides PS, only the closely related substances pregnenolone, DHEA and DHEA sulphate activated TRPM3 (Fig. 1c, e). We also searched for substances that may inhibit TRPM3 channels by testing substances that inhibit voltage-gated Ca2+ channels."
Given the similar properties of taurine and glycine, I think a combination of pregnenolone and one of these (or both) aino acids can be a very effective way to maintain proper glucose homeostasis.
Btw, DHEA and DHEA-W had the same effect but were much less potent than PS.
TRPM3 - Wikipedia, the free encyclopedia
"...The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been -identified.[2] TRPM3 was shown to be activated by the neurosteroid pregnenolone sulphate in pancreatic beta cell. The activation causes calcium influx and subsequent insulin release, therefore it is suggested that TRPM3 modulates glucose homeostasis."
http://www.nature.com/ncb/journal/v10/n12/full/ncb1801.html
"...We show here that TRPM3, a divalent-permeable cation channel, is rapidly and reversibly activated by extracellular pregnenolone sulphate, a neuroactive steroid. We show that pregnenolone sulphate activates endogenous TRPM3 channels in insulin-producing β cells. Application of pregnenolone sulphate led to a rapid calcium influx and enhanced insulin secretion from pancreatic islets. Our results establish that TRPM3 is an essential component of an ionotropic steroid receptor enabling unanticipated crosstalk between steroidal and insulin-signalling endocrine systems."
"...We tested several other steroids, including substances with important genomic functions, and found that besides PS, only the closely related substances pregnenolone, DHEA and DHEA sulphate activated TRPM3 (Fig. 1c, e). We also searched for substances that may inhibit TRPM3 channels by testing substances that inhibit voltage-gated Ca2+ channels."
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