deliciousfruit
Member
- Joined
- Dec 4, 2020
- Messages
- 238
The use of exogenous glucocorticoids such as Hydrocortisone over a long period of time can lead to adrenal suppression. Hydrocortisone inhibits the release of CRH from the hypothalamus, thus inhibiting the release of ACTH from the anterior pituitary gland. Over time, this leads to atrophy of the corticotrophin cells in the anterior pituitary gland, causing the suppressed synthesis of ACTH, and thus glucocorticoid release from the adrenal cortex.
Exogenous pregnenolone inhibits the release of CRH from the hypothalamus, thus inhibiting the release of ACTH from the anterior pituitary gland.
So does pregnenolone causes adrenal suppression? @haidut
The reason I ask is because after using topical pregnenolone for months, I now am completely debilitated with severe symptoms indicative of adrenal insufficiency.
Exogenous pregnenolone inhibits the release of CRH from the hypothalamus, thus inhibiting the release of ACTH from the anterior pituitary gland.
So does pregnenolone causes adrenal suppression? @haidut
The reason I ask is because after using topical pregnenolone for months, I now am completely debilitated with severe symptoms indicative of adrenal insufficiency.