Pregnenolone Acetate?

paymanz

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i want to know how likely is it buy a pregnenolone supplement and it contain the acetate form? do they mention it on bottel?
 
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paymanz

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anyone has any thought/info on this?

this is why i worry about this
ray peat said:
For example, steroid acetates are generally a little cheaper than the simple natural steroid. Some people assume that an acetate or butyrate can be substituted for the steroid itself. This can cause dangerous reactions......Pregnenolone acetate similarly blocks the enzymes which normally metabolize pregnenolone.
 
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Peat Tong

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I asked Swanson if their products had bioidentical pregnenolone or pregnenolone acetate.
They said, "After getting back in touch with our product specialist, our Swanson brand Pregnenolone is not in the form of bioidentical pregnenolone or pregnenolone acetate."
 
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Confused.... If I were to take pregnenolone and drink vinegar at the same time, would it have the same risks as taking pregnenolone acetate??
 

haidut

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I asked Swanson if their products had bioidentical pregnenolone or pregnenolone acetate.
They said, "After getting back in touch with our product specialist, our Swanson brand Pregnenolone is not in the form of bioidentical pregnenolone or pregnenolone acetate."

Wait, then what does it contain?
 

haidut

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Confused.... If I were to take pregnenolone and drink vinegar at the same time, would it have the same risks as taking pregnenolone acetate??

The acetate forms of steroids are not recommended, so by extension I don't think combining acetate and pregnenolone is a good idea.
Progesterone Summaries - Progesterone Deceptions - Progesterone Supplementation - Dosage of Progesterone
"...Medroxyprogesterone acetate is considered a progestin (though it is not supportive of gestation), because it modifies the uterus in approximately the wasy progesterone does, but it is luteolytic, and lowers the ovaries' production of progesterone while progesterone itself has a positive effect on the corpus luteum, stimulating progesterone synthesis. Defining “progestin” in a narrow way allows many synthetics to be sold as progestogens, though some of them are strongly estrogenic, allowing them to function as contraceptives--it is odd that contraceptives and agents which suppress progesterone synthesis should be officially called “supported of pregnancy.” It is probably partly the acetate group in the medroxyprogesterone acetate molecule which makes it bind firmly to receptors, yet causes it to block the enzymes which would normally be involved in progesterone metabolism. (I think testosterone, even, might be a safer progestin than medroxyprogesterone acetate.) Pregnenolone acetate similarly blocks the enzymes which normally metabolize pregnenolone. (12) In aspirin, it has been found that it is the acetyl group which (by a free radical action) blocks an enzyme involved in prostaglandin synthesis. "
 

cry0genicz

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It is possible that Ray Peat was taking pregnenolone acetate back in the 80's, but I don't think that's confirmed and I can't say with certainty with such limited info.

Ray: "When I was buying pregnenolone from the Syntex factory in Mexico, 1984-5, to test its safety I ate a kilogram of it during a year, 3000 to 4000 milligrams per day. I didn’t detect any side effects at all, except that my skin, that had been sagging over my eyes and on my neck, firmed up. I know a man in his sixties who is taking a teaspoonful every day, without any bad effects."

An entry from Google search for 'syntex pregnenolone':
The Pharmaceutical Industry and Dependency in the Third World
https://books.google[.]com/books?isbn=1400886228
Gary Gereffi - 2017 - ‎Business & Economics
"In the ensuing flurry of activity more than two million dollars worth of pregnenolone acetate was produced and sold, almost entirely by Syntex. Unfortunately it was soon discovered that the sole basis for remission in the arthritic had been enthusiasm by the patient or his physician rather than pregnenolone. Although public ..."
 

haidut

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No one at Swanson has been able to answer this.

That's pretty concerning because it violates FDA rules to have the proper ingredient listed on the label. Surprised to see it in a big vendor like Swanson. Unlike fats, where the label can say just "MCT or SFA", the rules are a little different for steroids - i.e. the exact steroid (and its salt) need to be specified. If somebody talks to Swanson again then this can be brought up.
It reminds me once again that most of the big vendors probably sell pure junk or seriously compromised ingredient since they have contracts for production where they get whatever the production/bottling vendor offers as bulk ingredients. One more reason for us to never outsource any portion of the business. Sometimes it helps to be small :):
 

Green Dot

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That's pretty concerning because it violates FDA rules to have the proper ingredient listed on the label. Surprised to see it in a big vendor like Swanson. Unlike fats, where the label can say just "MCT or SFA", the rules are a little different for steroids - i.e. the exact steroid (and its salt) need to be specified. If somebody talks to Swanson again then this can be brought up.
It reminds me once again that most of the big vendors probably sell pure junk or seriously compromised ingredient since they have contracts for production where they get whatever the production/bottling vendor offers as bulk ingredients. One more reason for us to never outsource any portion of the business. Sometimes it helps to be small :):
Any updates?
 

Clyde

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I asked Swanson if their products had bioidentical pregnenolone or pregnenolone acetate.
They said, "After getting back in touch with our product specialist, our Swanson brand Pregnenolone is not in the form of bioidentical pregnenolone or pregnenolone acetate."
This is completely shocking! Doesn't seem possible.

I tried their pregnenolone about 3 years ago. Now I have to find out if it was formulated with pregnenolone lol. But if their pregnenolone products don't necessarily contain pregnenolone then it could have anything in it bc the label is meaningless. The label didn't say silica but why not put silica in it?
 
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Makrosky

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This is completely shocking! Doesn't seem possible.

I tried their pregnenolone about 3 years ago. Now I have to find out if it was formulated with pregnenolone lol. But if their pregnenolone products don't necessarily contain pregnenolone then it could have anything in it bc the label is meaningless. The label didn't say silica but why not put silica in it?
Buy from healthnatura. It's legit. Idealabs is legit as well. No need to go to those big brand scammers.
 

Clyde

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Buy from healthnatura. It's legit. Idealabs is legit as well. No need to go to those big brand scammers.
Yeah, well I guess you have no choice unless you're into reverse purity. Pure unadulterated excipient😜
 
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