Ingenol

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Nov 25, 2012
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I haven't seen this discussed here, and an unfruitful search of Ray's site suggests he hasn't commented on it directly there either. PQQ is pyrryoloquinoline quinone and seems to be beneficial in humans to both protect mitochondria from oxidative damage and to encourage mitochondrial biogenesis. It would seem that these beneficial effects are extremely in line with a Peat-inspired template in order to maximize aerobic metabolism.

Is anyone here taking PQQ? Thoughts? Has this been discussed somewhere that I'm not aware of?
 

charlie

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Ingenol, welcome to the forum! :welcome

I have never heard anything about that, but hopefully you will find some answers here.

See you around! :wave:
 

fat4thought

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Aug 29, 2012
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I just got some. I was intrigued after having good luck with K2 and Vitamin E. I thought trying another quinone might be useful, and the information on the Wiki was appealing.

I got the LEF stuff, and I emptied it out of its capsules (they are made of cellulose). There is still rice starch... but I eat rice. :)

Too early to say much, but so far it doesn't seem to be a *bad* addition.
 

astral

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Nov 6, 2012
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fat4thought said:
I just got some. I was intrigued after having good luck with K2 and Vitamin E. I thought trying another quinone might be useful, and the information on the Wiki was appealing.

I got the LEF stuff, and I emptied it out of its capsules (they are made of cellulose). There is still rice starch... but I eat rice. :)

Too early to say much, but so far it doesn't seem to be a *bad* addition.
I asked ray peat what he thought of PQQ he replied no interest
he liked vitamin k-2
he wrote about coenzyme q10 in 1976 newsletter believe or not
I am using idebenone (150 mgs per day)
loved it very much I think it is better than PQQ and other forms of q10
paul
 

kiran

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Aug 9, 2012
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PQQ helped me a bit back in the day. It does nothing for me now.
 

jyb

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astral said:
fat4thought said:
I just got some. I was intrigued after having good luck with K2 and Vitamin E. I thought trying another quinone might be useful, and the information on the Wiki was appealing.

I got the LEF stuff, and I emptied it out of its capsules (they are made of cellulose). There is still rice starch... but I eat rice. :)

Too early to say much, but so far it doesn't seem to be a *bad* addition.
I asked ray peat what he thought of PQQ he replied no interest
he liked vitamin k-2
he wrote about coenzyme q10 in 1976 newsletter believe or not
I am using idebenone (150 mgs per day)
loved it very much I think it is better than PQQ and other forms of q10
paul


Random thoughts on the relative merits of idebenone and q10...

But when oxygen is in short supply, CoQ10 diverts some of these electrons into free-radical production, and the radicals damage any tissue they reach. Idebenone is thought to differ from CoQ10 in that it somehow avoids this destructive production of free radicals.
from http://www.beyond-a-century.com/Idebeno ... p_149.html

Idebenone – synthetic analog with reduced oxidant generating properties
from http://en.wikipedia.org/wiki/Coenzyme_Q ... ary_intake
 
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Here is a study which shows pqq having positive effects. Keep in mind I don't know how to read these 100% but it seems to showcase pqq having some sort of anti inflammatory effect

Jack kruse also regards this highly. He has it in his top 10 paleo supplements list https://www.jackkruse.com/top-ten-paleo-supplements/

I also found it interesting that there a conference for the coq10 supplement alone. I would love to watch some of this as I have become a believer that mitochondria health is vital for awesome health and wellbeing

Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. - PubMed - NCBI
 

Wayner82

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Oct 10, 2017
Messages
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Hi

New to the forum but I have been researching pqq and uses to prevent oxidative stree as I have an optic nerve condition, I take Idebenone currently but are these 2 supplements basically the same and taking both would cancel the effects out of each other? Any information anyone can give will be greatly appreciated.
 

johnwester130

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Aug 6, 2015
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it seems very novel

there is no need to reinvent the wheel , which is what expensive supplements usually are.

"Riboflavin, coenzyme Q10, vitamin K, niacinamide, thiamine, and selenium are the nutrients that most directly relate to mitochondrial energy production. "

""Further therapeutic indications
Due to its anti-inflammatory, anti-oxidative and anticarcinogenic properties, vitamin K, particularly MK-7, may be of interest in a number of other diseases (e.g., cancer, diabetes, age-related macular degeneration [AMD]); over the next few years, studies will show whether this is the case. Furthermore, because of its structural similarity to coenzyme Q10, it is likely that MK-7 is a Q10 mimetic with respect to the mitochondria and supports mitochondrial adenosine triphosphate (ATP) production in the respiratory chain.""
 

johnwester130

Member
Joined
Aug 6, 2015
Messages
2,776
Hi

New to the forum but I have been researching pqq and uses to prevent oxidative stree as I have an optic nerve condition, I take Idebenone currently but are these 2 supplements basically the same and taking both would cancel the effects out of each other? Any information anyone can give will be greatly appreciated.

lol you have 1 post

but generally, no, PQQ is not the answer to our problems
 

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