Potato Juice Exerts An Anticonvulsant Effect In Mice Through Binding To GABA Rec

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Potato (Solanum Tuberosum) Juice Exerts an Anticonvulsant Effect in Mice Through Binding to GABA Receptors
Ruta Muceniece 1, Kristine Saleniece, Liga Krigere, Juris Rumaks, Zane Dzirkale, Rudolfs Mezhapuke, Jorens Kviesis, Peteris Mekss, Vija Klusa, Helgi B Schiöth, Maija Dambrova
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Abstract


Naturally occurring benzodiazepines have been identified in regular food such as wheat and potato, but there is still no evidence that potato extracts can affect CNS responses in vivo. Here we found that undiluted potato juice and potato juice diluted with saline 1 : 2 administered 10 min intracisternally ( I. C.) and 30 min per os before bicuculline exerted significant anticonvulsant activity in the bicuculline-induced seizure threshold test in mice. In vitro, potato juice from different harvests at dilution series from 10 % to 0.000001 %, diluted 100,000-fold, displaced 50 % of gamma-aminobutyric acid (GABA) receptor ligand [ (3)H]GABA and diluted 40-fold displaced 50 % of [(3)H]flunitrazepam from binding sites in mice forebrain membranes. The low content of diazepam (0.04 +/- 0.01 mg/kg) determined by HPLC and mass spectrometry in the potato extracts could not sustain the anticonvulsant activity of potato juice in vivo; therefore we hypothesized that potato juice might contain GABA (A) receptor GABA-site active compounds. The findings of this study suggest that potato juice as well as potato taken as food may have the capacity of influencing brain GABA-ergic activity.
 

Ben.

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...in the potato extracts could not sustain the anticonvulsant activity of potato juice in vivo; therefore we hypothesized that potato juice might contain GABA (A) receptor GABA-site active compounds. The findings of this study suggest that potato juice as well as potato taken as food may have the capacity of influencing brain GABA-ergic activity.

Wait. Do i understand this correctly?

Since the anticonvulsant activity couldn't be sustained by a one time usage it had to be due to a GABA receptor active compounds which eventually will be used up?

I Know it says "hypothesized" but in plain easy words it means that potatos "may" have an temporary effect on our GABA mechanisms/system.

Either way good to know ... i love potatoes.
 

dabdabdab

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there was a post on this forum about benzodine being a nitrate scavenger and the real reason behind its psychological effect on schizophrenia. since mania is related to brain ammonia content. not sure if benzodine has direct impact on gaba
 
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