nigma
Member
- Joined
- Dec 14, 2013
- Messages
- 218
There is a somewhat well known idea of Ray's that says insulin plays a smaller part in the insulin effect than insulin itself. While potassium looks to be the main actor in getting glucose into cells.
from 'Glycemia, starch, and sugar in context'
"Insulin is important in the regulation of blood sugar, but its importance has been exaggerated because of the diabetes/insulin industry. Insulin itself has been found to account for only about 8% of the "insulin-like activity" of the blood, with potassium being probably the largest factor. There probably isn't any process in the body that doesn't potentially affect blood sugar."
I've been looking into the interaction between insulin, potassium and glucose and reading some papers. Was looking for the original paper which found that an atom of potassium is needed for every glucose molecule to enter a cell. Haven't found it yet but did find some interesting stuff. Such as, in low potassium people a fraction of the insulin they produce is of an 'abnormal molecular species' which is 'poorly active'. Is this describing insulin resistance? I thought it was considered that something was wrong with the insulin receptors rather then insulin itself.
Kidney Int. 1977 Jun;11(6):443-52.
Role of glucoregulatory hormones in potassium homeostasis.
Knochel JP.
Role of glucoregulatory hormones in potassium homeostasis. - PubMed - NCBI
This got me thinking of Gilbert Lings model. As he sees K+ adsorbing onto proteins inside the cell in the resting state, I wonder how general this idea is. I know the extra cellular fluid such as blood has less potassium than inside the cell, but is it possible other proteins also have potassium adsorbed to give them the correct conformation? In the case of insulin, could this abnormal species that was found have some missing potassium? Or perhaps the receptor is missing some adsorbed K+ resulting in lowered function?
Does anyone know how they characterize proteins? Would electrolytes like K, Na, Mg, Ca come off the protein due to the way they are characterized?.
There are lots of hints in this paper that support the idea that diabetes is caused by potassium deficiency. The fact that Ray Peat's father and others were treated with brewers yeast for diabetes is also supportive of the idea since brewers yeast has a very high K/Na ratio.
from 'Glycemia, starch, and sugar in context'
"Insulin is important in the regulation of blood sugar, but its importance has been exaggerated because of the diabetes/insulin industry. Insulin itself has been found to account for only about 8% of the "insulin-like activity" of the blood, with potassium being probably the largest factor. There probably isn't any process in the body that doesn't potentially affect blood sugar."
I've been looking into the interaction between insulin, potassium and glucose and reading some papers. Was looking for the original paper which found that an atom of potassium is needed for every glucose molecule to enter a cell. Haven't found it yet but did find some interesting stuff. Such as, in low potassium people a fraction of the insulin they produce is of an 'abnormal molecular species' which is 'poorly active'. Is this describing insulin resistance? I thought it was considered that something was wrong with the insulin receptors rather then insulin itself.
Kidney Int. 1977 Jun;11(6):443-52.
Role of glucoregulatory hormones in potassium homeostasis.
Knochel JP.
Role of glucoregulatory hormones in potassium homeostasis. - PubMed - NCBI
This got me thinking of Gilbert Lings model. As he sees K+ adsorbing onto proteins inside the cell in the resting state, I wonder how general this idea is. I know the extra cellular fluid such as blood has less potassium than inside the cell, but is it possible other proteins also have potassium adsorbed to give them the correct conformation? In the case of insulin, could this abnormal species that was found have some missing potassium? Or perhaps the receptor is missing some adsorbed K+ resulting in lowered function?
Does anyone know how they characterize proteins? Would electrolytes like K, Na, Mg, Ca come off the protein due to the way they are characterized?.
There are lots of hints in this paper that support the idea that diabetes is caused by potassium deficiency. The fact that Ray Peat's father and others were treated with brewers yeast for diabetes is also supportive of the idea since brewers yeast has a very high K/Na ratio.