Piracetam

[Such_Saturation]

Oh god not that guy

 

[CoolTweetPete]

post 109243 On the longcity web site there's a legendary piracetem user called Isochroma. On a MB thread he called MB a reasonable alternative to piracetem at 200 mg a day. Of course he's chugging 30 grams of fish oil to keep his membranes fluid.

Fish oil and Methylene Blue? This gentleman might be a fish.

 

[ken]

After affirming that he was Isochroma, the next poster blurted out " man, I thought you died".

 

[ken]

Actually it was interesting, his comments, because we haven't any testimony from people taking sustained high doses. He said it made him feel very clear and energetic. And that he was noticing more and more memories. Made a joke that might of been the reason for the drug name Rember.

 

[Such_Saturation]

Nah, he got tired of that too. Next up was pramiracetam which apparently was the only thing worthy of his time, until he switched to IDRA-21 or something of that sort. Also I think he was without a home for at least that period.

 

[DaveFoster]

I find Isochroma incredibly interesting; he's borderline autistic I believe. I didn't know he had such a reputation.

 

[DaveFoster]

Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats. - PubMed - NCBI

"No significant changes following choline administration were observed in the hippocampus. However, piracetam alone markedly increased choline content in hippocampus (88%) and tended to decrease acetylcholine levels (19%). No measurable changes in striatum or cortex were observed following piracetam administration."

 

[Koveras]

Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats. - PubMed - NCBI

"No significant changes following choline administration were observed in the hippocampus. However, piracetam alone markedly increased choline content in hippocampus (88%) and tended to decrease acetylcholine levels (19%). No measurable changes in striatum or cortex were observed following piracetam administration."

Kind of like how theanine increases brain tryptophan and decreases serotonin

 

[Drareg]

Kind of like how theanine increases brain tryptophan and decreases serotonin

Where did you see this Koveras? I got the impression from Peats articles, one very recent that Theanine is very positive and possibly breaking down serotonin,removing it, seems pointless to take if it increases tryptophan, stress will convert this I'm guessing.

 

[Drareg]

Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats. - PubMed - NCBI

"No significant changes following choline administration were observed in the hippocampus. However, piracetam alone markedly increased choline content in hippocampus (88%) and tended to decrease acetylcholine levels (19%). No measurable changes in striatum or cortex were observed following piracetam administration."

The cardiolipin contains phosphotidylcholine but not the cheap form which is unsaturated and rancid according to Peat , DPPC is the best form. Check out this thread, very interesting with the above study?
Peat is all about the cardiolipin I think, I'm trying to learn more about it buy it seems like the key to restoration of close to perfect metabolism .

Saturated fats and mitochondrias | Page 2 | Ray Peat Forum

 

[DaveFoster]

The cardiolipin contains phosphotidylcholine but not the cheap form which is unsaturated and rancid according to Peat , DPPC is the best form. Check out this thread, very interesting with the above study?
Peat is all about the cardiolipin I think, I'm trying to learn more about it buy it seems like the key to restoration of close to perfect metabolism .

Saturated fats and mitochondrias | Page 2 | Ray Peat Forum

Thanks for the link; I'm very interested in this. Would DPPC replace saturated fats or serve as a supplement?

 

[Koveras]

Where did you see this Koveras? I got the impression from Peats articles, one very recent that Theanine is very positive and possibly breaking down serotonin,removing it, seems pointless to take if it increases tryptophan, stress will convert this I'm guessing.

Most likely what is happening is it is interfering with the conversion of tryptophan to serotonin, thus the precursor is accumulating. Possibly what is happening with piracetam is it is preventing the conversion of choline to acetylcholine in some tissues.

Theanine-induced reduction of brain serotonin concentration in rats. - PubMed - NCBI

"Following the administration of theanine, the brain tryptophan content significantly increased or tended to increase, but the contents of serotonin and 5-hydroxyindole acetic acid (5HIAA) decreased. The use of inhibitors of serotonin metabolism enable us to speculate that theanine reduced serotonin synthesis and also increased serotonin degradation in the brain."

 

[jb116]

Increased tryptophan would still prsent as a problem attaching to albumin

 

[Drareg]

I'm not sure if it's a replacement.
Haidut mentions thread it's very expensive, probably worth a try if it reverses the cardiolipin to saturated.
I'm really interested in this, Peat may mention in an article that t3 can do it? I'd have to find that though.
What does a study like this indicate ? Prednisone can be replaced with pregnenolone?
Prevention of anticardiolipin antibody-related pregnancy losses with prednisone and aspirin. - PubMed - NCBI

 

[thyrulian]

Terrible anxiety/dysphoria with chronic use.

 

[DaveFoster]

Terrible anxiety/dysphoria with chronic use.

Piracetam or DPPC?

 

[thyrulian]

Piracetam or DPPC?

Piracetam.

 

[Drareg]

Increased tryptophan would still prsent as a problem attaching to albumin

What to do here?
If tryptophan is not been converted what is going to do ? Attach to albumin?
Aspirin stops tryptophan absorbing in gut?
B6 converts it to b3 , BCAA stop tyrosine also so not ideal.
Gelatin just blocks it also ,does destroy it.
Caffeine is behaving the same ,pcpa also just inhibiting the conversion enzyme.

Tryptophan destroyer is necessary ? Any ideas besides aspirin, and aspirin only gets it in the gut no?

 

[DaveFoster]

What to do here?
If tryptophan is not been converted what is going to do ? Attach to albumin?
Aspirin stops tryptophan absorbing in gut?
B6 converts it to b3 , BCAA stop tyrosine also so not ideal.
Gelatin just blocks it also ,does destroy it.
Caffeine is behaving the same ,pcpa also just inhibiting the conversion enzyme.

Tryptophan destroyer is necessary ? Any ideas besides aspirin, and aspirin only gets it in the gut no?

You could always block absorption with BCAA's or reduce the amount of tryptophan in your diet. Then you wouldn't need to worry about conversion.

 

[Drareg]

I use milk a lot ,really helps,2% fat, cheese.
Eggs too.
BCAA just blocks, theanine,caffeine inhibit the conversion enzyme.
This thread has good info on it
Aspirin inhibits tryptophan absorption from the intestine