Mauritio
Member
- Joined
- Feb 26, 2018
- Messages
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Picamilon is a molecular combination of vitamin B3 and GABA , created in russia .
It crossed the blood brain barrier and then gets metabolized into B3 and GABA .
Thus it was shown to have brain protective , mood enhancing, and lactate lowering effects .
It helps to treat parkinsons ,by enhancing dopamine :
"It was shown that NAm was more effective on serotonin content while nicotinoyl-GABA on dopamine one. Dopamine uptake was impaired at experimental parkinsonism and partially was normalized by incubation with NAD (10(-6) M). Thus, NAm, nicotinoyl-GABA and NAD are involved in the regulation of brain neurotransmission under experimental parkinsonism and can be useful in treatment of Parkinson's disease.
([Correction by nicotinamide and nicotinoyl-GABA of dopamine metabolism in rat brain in experimental Parkinson's disease] - PubMed)
It enhances oxidative phosphorylation in the brain , probably by shifting the NAD/NADH ratio.
([The effect of nootropic agents on brain mitochondrial function in the dynamics of craniocerebral trauma from the age aspect] - PubMed)
It enhances blood flow in the brain, I read somewhere else about 5 -10% improvement .
Plus this study shows it reverses some of serotonins effects on the brain .
"Picamilon, a sodium salt of N-nicotinoyl-gamma-aminobutyric acid, was shown to induce a significant increase of cerebral blood flow in conscious cats. Picamilon was found to inhibit neurogenic spasms of cerebral vessels that was followed by suppression of tonic activity and reflectory discharges in sympathetic nerves. Picamilon led to restoration of the initial condition of cerebral hemodynamics disturbed by a previous administration of serotonin."
It crossed the blood brain barrier and then gets metabolized into B3 and GABA .
Thus it was shown to have brain protective , mood enhancing, and lactate lowering effects .
It helps to treat parkinsons ,by enhancing dopamine :
"It was shown that NAm was more effective on serotonin content while nicotinoyl-GABA on dopamine one. Dopamine uptake was impaired at experimental parkinsonism and partially was normalized by incubation with NAD (10(-6) M). Thus, NAm, nicotinoyl-GABA and NAD are involved in the regulation of brain neurotransmission under experimental parkinsonism and can be useful in treatment of Parkinson's disease.
([Correction by nicotinamide and nicotinoyl-GABA of dopamine metabolism in rat brain in experimental Parkinson's disease] - PubMed)
It enhances oxidative phosphorylation in the brain , probably by shifting the NAD/NADH ratio.
([The effect of nootropic agents on brain mitochondrial function in the dynamics of craniocerebral trauma from the age aspect] - PubMed)
It enhances blood flow in the brain, I read somewhere else about 5 -10% improvement .
Plus this study shows it reverses some of serotonins effects on the brain .
"Picamilon, a sodium salt of N-nicotinoyl-gamma-aminobutyric acid, was shown to induce a significant increase of cerebral blood flow in conscious cats. Picamilon was found to inhibit neurogenic spasms of cerebral vessels that was followed by suppression of tonic activity and reflectory discharges in sympathetic nerves. Picamilon led to restoration of the initial condition of cerebral hemodynamics disturbed by a previous administration of serotonin."