Peat has written many times on the link between periodontal disease, and endotoxin. He mentioned how a few dentists he knows stopped doing dental cleaning after they found that that giving their patients laxatives or antibiotics cured their gum disease. In addition, a few studies came out recently claiming a link between endotoxin/iron and a host of systemic issues, including neurodegenerative conditions like AD.
Endotoxin And Iron Finally Recognized As Potential Causes Of Many Diseases
Endotoxin (LPS) Theory Of Atherosclerosis (CVD)
Dementia Breakthrough - Alzheimer Disease Linked To Endotoxin And Iron
So, it appears the link between periodontal disease and chronic systemic diseases should be rather obvious. However, mainstream medicine continues to deny that such a link exists. This new study below may begin to change that view, as it discovered a strong link between periodontal disease and AD. The only drawback of the study is that is still looks at the issue as a local pathology - i.e. it is oral bacteria exposure only that caused AD. But, as I mentioned above, periodontal disease is a known result of intestinal inflammation and endotoxin. The sooner medicine starts looking at this as a systemic issue the sooner viable therapies will emerge. Charcoal, emodin, antibiotics, anti-serotonin drugs, etc are likely to become some of the most successful drugs in the near future, once medicine gets its act together.
Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice
Study: Periodontal disease may spur Alzheimer's
"...Exposure to periodontal bacteria may initiate Alzheimer's disease in humans based upon inflammation and degeneration of brain neurons in mice, according to a study. Researchers at the University of Illinois at Chicago studied the effects of periodontal disease, a common but preventable gum infection, with Alzheimer's, which currently has no treatment or cure. The findings were published Wednesday in PLOS One."
"..."This was a big surprise," corresponding author Dr. Keiko Watanabe, a professor of periodontics at the UIC College of Dentistry, said in a press release. "We did not expect that the periodontal pathogen would have this much influence on the brain, or that the effects would so thoroughly resemble Alzheimer's disease." Watanabe noted other studies found a close association between periodontitis and cognitive impairment, "but this is the first study to show that exposure to the periodontal bacteria results in the formation of senile plaques that accelerate the development of neuropathology found in Alzheimer's patients."
Endotoxin And Iron Finally Recognized As Potential Causes Of Many Diseases
Endotoxin (LPS) Theory Of Atherosclerosis (CVD)
Dementia Breakthrough - Alzheimer Disease Linked To Endotoxin And Iron
So, it appears the link between periodontal disease and chronic systemic diseases should be rather obvious. However, mainstream medicine continues to deny that such a link exists. This new study below may begin to change that view, as it discovered a strong link between periodontal disease and AD. The only drawback of the study is that is still looks at the issue as a local pathology - i.e. it is oral bacteria exposure only that caused AD. But, as I mentioned above, periodontal disease is a known result of intestinal inflammation and endotoxin. The sooner medicine starts looking at this as a systemic issue the sooner viable therapies will emerge. Charcoal, emodin, antibiotics, anti-serotonin drugs, etc are likely to become some of the most successful drugs in the near future, once medicine gets its act together.
Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice
Study: Periodontal disease may spur Alzheimer's
"...Exposure to periodontal bacteria may initiate Alzheimer's disease in humans based upon inflammation and degeneration of brain neurons in mice, according to a study. Researchers at the University of Illinois at Chicago studied the effects of periodontal disease, a common but preventable gum infection, with Alzheimer's, which currently has no treatment or cure. The findings were published Wednesday in PLOS One."
"..."This was a big surprise," corresponding author Dr. Keiko Watanabe, a professor of periodontics at the UIC College of Dentistry, said in a press release. "We did not expect that the periodontal pathogen would have this much influence on the brain, or that the effects would so thoroughly resemble Alzheimer's disease." Watanabe noted other studies found a close association between periodontitis and cognitive impairment, "but this is the first study to show that exposure to the periodontal bacteria results in the formation of senile plaques that accelerate the development of neuropathology found in Alzheimer's patients."