Perinatal Administration Of Aromatase Inhibitors In Animal Models Of Human Male Homosexuality

[meatbag]

Perinatal Administration of Aromatase Inhibitors in Rodents as Animal Models of Human Male Homosexuality: Similarities and Differences
--
Abstract
In this chapter we briefly review the evidence supporting the existence of biological influences on sexual orientation. We focus on basic research studies that have affected the estrogen synthesis during the critical periods of brain sexual differentiation in male rat offspring with the use of aromatase inhibitors, such as 1,4,6-androstatriene-3,17 (ATD) and letrozole. The results after prenatal and/or postnatal treatment with ATD reveal that these animals, when adults, show female sexual responses, such as lordosis or proceptive behaviors, but retain their ability to display male sexual activity with a receptive female. Interestingly, the preference and sexual behavior of these rats vary depending upon the circadian rhythm.Recently, we have established that the treatment with low doses of letrozole during the second half of pregnancy produces male rat offspring, that when adults spend more time in the company of a sexually active male than with a receptive female in a preference test. In addition, they display female sexual behavior when forced to interact with a sexually experienced male and some typical male sexual behavior when faced with a sexually receptive female. Interestingly, these males displayed both sexual behavior patterns spontaneously, i.e., in absence of exogenous steroid hormone treatment. Most of these features correspond with those found in human male homosexuals; however, the "bisexual" behavior shown by the letrozole-treated rats may be related to a particular human population. All these data, taken together, permit to propose letrozole prenatal treatment as a suitable animal model to study human male homosexuality and reinforce the hypothesis that human sexual orientation is underlied by changes in the endocrine milieu during early development.
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Perinatal Administration of Aromatase Inhibitors in Rodents as Animal Models of Human Male Homosexuality: Similarities and Differences - PubMed
--
via:
https://twitter.com/uptophate

 

[Inaut]

Interesting study @meatbag

 

[lvysaur]

Very interesting study. So lowering estrogen with letrozole seems to turn rats gay/bisexual?

 

[Vinny]

Very interesting study. So lowering estrogen with letrozole seems to turn rats gay/bisexual?

I'm not good understanding scientific language, but I got it like you.

 

[gaze]

Progesterone and bisexuality: Is there a link?

Bisexuality is quite common among men and women whose mothers received additional doses of the sex hormone progesterone while pregnant. This is one of the findings of a study led by June Reinisch, Director Emerita of The Kinsey Institute in the US, published in Springer's journal Archives of...

www.eurekalert.org

"It was found that men and women whose mothers were treated with progesterone were significantly less likely to describe themselves as heterosexual. One in every five (20.6 percent) of the progesterone- exposed participants labeled themselves as other than heterosexual. Compared to the untreated group, the chances were greater that by their mid-20s they had already engaged in some form of same-sex sexual behavior (in up to 24.2 percent of cases), and that they were attracted to the same (29.4 percent) or to both sexes (17.6 percent). Both exposed males and females also had higher scores related to attraction to men."

it's only a 34 person study so take it for what it's worth

 

[tankasnowgod]

Perinatal Administration of Aromatase Inhibitors in Rodents as Animal Models of Human Male Homosexuality: Similarities and Differences
--
Abstract
In this chapter we briefly review the evidence supporting the existence of biological influences on sexual orientation. We focus on basic research studies that have affected the estrogen synthesis during the critical periods of brain sexual differentiation in male rat offspring with the use of aromatase inhibitors, such as 1,4,6-androstatriene-3,17 (ATD) and letrozole. The results after prenatal and/or postnatal treatment with ATD reveal that these animals, when adults, show female sexual responses, such as lordosis or proceptive behaviors, but retain their ability to display male sexual activity with a receptive female. Interestingly, the preference and sexual behavior of these rats vary depending upon the circadian rhythm.Recently, we have established that the treatment with low doses of letrozole during the second half of pregnancy produces male rat offspring, that when adults spend more time in the company of a sexually active male than with a receptive female in a preference test. In addition, they display female sexual behavior when forced to interact with a sexually experienced male and some typical male sexual behavior when faced with a sexually receptive female. Interestingly, these males displayed both sexual behavior patterns spontaneously, i.e., in absence of exogenous steroid hormone treatment. Most of these features correspond with those found in human male homosexuals; however, the "bisexual" behavior shown by the letrozole-treated rats may be related to a particular human population. All these data, taken together, permit to propose letrozole prenatal treatment as a suitable animal model to study human male homosexuality and reinforce the hypothesis that human sexual orientation is underlied by changes in the endocrine milieu during early development.
--
Perinatal Administration of Aromatase Inhibitors in Rodents as Animal Models of Human Male Homosexuality: Similarities and Differences - PubMed
--
via:
https://twitter.com/uptophate

While letrozole does inhibit aromatase, it is also estrogenic as well.

Some aromatase inhibitors (AI) are estrogenic – To Extract Knowledge from Matter

Of course, interfering with reproductive hormones during pregnancy could likely have all sorts of unforeseen effects.

 

[Mauritio]

Progesterone and bisexuality: Is there a link?

Bisexuality is quite common among men and women whose mothers received additional doses of the sex hormone progesterone while pregnant. This is one of the findings of a study led by June Reinisch, Director Emerita of The Kinsey Institute in the US, published in Springer's journal Archives of...

www.eurekalert.org

"It was found that men and women whose mothers were treated with progesterone were significantly less likely to describe themselves as heterosexual. One in every five (20.6 percent) of the progesterone- exposed participants labeled themselves as other than heterosexual. Compared to the untreated group, the chances were greater that by their mid-20s they had already engaged in some form of same-sex sexual behavior (in up to 24.2 percent of cases), and that they were attracted to the same (29.4 percent) or to both sexes (17.6 percent). Both exposed males and females also had higher scores related to attraction to men."

it's only a 34 person study so take it for what it's worth

The progesterone thing is interesting. Maybe it's just a healthy natural state to be bicurious or bisexual , I think the progesterone didnt make them exclusively gay, did it ?
Haidut also posted a study a few years ago on mice becoming bisexual after getting a dopamin agonist/ serotonin antagonist.

 

[rebuke]

Prog treated mothers most likely refers to synthetic progestins which Ray says are estrogenic. As mentioned earlier some AIs, like the one used in the study are also estrogenic.

Synthetic Progestins Are Estrogenic And Promote Cancer Through FAS

As many forum users know, the debate over the role of progesterone in breast cancer has been raging since the 1950s when the first synthetic progestins hit the market. Peat is strong proponent of the beneficial and anti-cancer effects of bioidentical progesterone, while at the same time voicing...

raypeatforum.com

 

[ecstatichamster]

Prog treated mothers most likely refers to synthetic progestins which Ray says are estrogenic. As mentioned earlier some AIs, like the one used in the study are also estrogenic.

Synthetic Progestins Are Estrogenic And Promote Cancer Through FAS

As many forum users know, the debate over the role of progesterone in breast cancer has been raging since the 1950s when the first synthetic progestins hit the market. Peat is strong proponent of the beneficial and anti-cancer effects of bioidentical progesterone, while at the same time voicing...

raypeatforum.com

that’s what I was thinking. Do they really mean progesterone? I doubt it.

 

[boris]

Exactly @rebuke @ecstatichamster

Progesterone and bisexuality: Is there a link?

Bisexuality is quite common among men and women whose mothers received additional doses of the sex hormone progesterone while pregnant. This is one of the findings of a study led by June Reinisch, Director Emerita of The Kinsey Institute in the US, published in Springer's journal Archives of...

www.eurekalert.org

"It was found that men and women whose mothers were treated with progesterone were significantly less likely to describe themselves as heterosexual. One in every five (20.6 percent) of the progesterone- exposed participants labeled themselves as other than heterosexual. Compared to the untreated group, the chances were greater that by their mid-20s they had already engaged in some form of same-sex sexual behavior (in up to 24.2 percent of cases), and that they were attracted to the same (29.4 percent) or to both sexes (17.6 percent). Both exposed males and females also had higher scores related to attraction to men."

it's only a 34 person study so take it for what it's worth

"The 17 men and 17 women were selected because their mothers exclusively received the progesterone lutocyclin"

Lutocyclin is not progesterone. It's a synthetic progestin.

RU486, cancer, estrogen, and progesterone.

Ray Peat

raypeat.com

Unfortunately, those synthetic compounds have a variety of functions unlike progesterone, including some estrogenic and/or androgenic and/or glucocorticoid and/or antiprogesterone functions, besides other special, idiosyncratic side effects. The rationale for their use was that they were "like progesterone, only better." The unpleasant and unwanted truth is that, as a group, they are seriously carcinogenic, besides being toxic in a variety of other ways.

 

[ecstatichamster]

Exactly @rebuke @ecstatichamster



"The 17 men and 17 women were selected because their mothers exclusively received the progesterone lutocyclin"

Lutocyclin is not progesterone. It's a synthetic progestin.

thank you for the clarification.

 

[gaze]

thank you for the clarification.

+1

 

[Nebula]

Progesterone and bisexuality: Is there a link?

Bisexuality is quite common among men and women whose mothers received additional doses of the sex hormone progesterone while pregnant. This is one of the findings of a study led by June Reinisch, Director Emerita of The Kinsey Institute in the US, published in Springer's journal Archives of...

www.eurekalert.org

"It was found that men and women whose mothers were treated with progesterone were significantly less likely to describe themselves as heterosexual. One in every five (20.6 percent) of the progesterone- exposed participants labeled themselves as other than heterosexual. Compared to the untreated group, the chances were greater that by their mid-20s they had already engaged in some form of same-sex sexual behavior (in up to 24.2 percent of cases), and that they were attracted to the same (29.4 percent) or to both sexes (17.6 percent). Both exposed males and females also had higher scores related to attraction to men."

it's only a 34 person study so take it for what it's worth

Things like this are why I remain skeptical that any exogenous hormones are safe.

Prog treated mothers most likely refers to synthetic progestins which Ray says are estrogenic. As mentioned earlier some AIs, like the one used in the study are also estrogenic.

Synthetic Progestins Are Estrogenic And Promote Cancer Through FAS

As many forum users know, the debate over the role of progesterone in breast cancer has been raging since the 1950s when the first synthetic progestins hit the market. Peat is strong proponent of the beneficial and anti-cancer effects of bioidentical progesterone, while at the same time voicing...

raypeatforum.com

Looks like this study was from the 1960’s and specifically looked at the effects of lutocyclin which was just a brand name for Ethisterone

Ethisterone - Wikipedia

en.m.wikipedia.org

It was found to have masculinizing effects so was discontinued. Quite a jump in logic to compare this to bioidentical progesterone.

Synthetic and downstream hormones don’t seem to have a good track record for health and almost always have strange unwanted side effects. I even regret messing around with Keto DHT. Much preferable to fix energy metabolism as upstream as possible imo.

 

[gaze]

deleted

 

[Drareg]

Progesterone and bisexuality: Is there a link?

Bisexuality is quite common among men and women whose mothers received additional doses of the sex hormone progesterone while pregnant. This is one of the findings of a study led by June Reinisch, Director Emerita of The Kinsey Institute in the US, published in Springer's journal Archives of...

www.eurekalert.org

"It was found that men and women whose mothers were treated with progesterone were significantly less likely to describe themselves as heterosexual. One in every five (20.6 percent) of the progesterone- exposed participants labeled themselves as other than heterosexual. Compared to the untreated group, the chances were greater that by their mid-20s they had already engaged in some form of same-sex sexual behavior (in up to 24.2 percent of cases), and that they were attracted to the same (29.4 percent) or to both sexes (17.6 percent). Both exposed males and females also had higher scores related to attraction to men."

it's only a 34 person study so take it for what it's worth

The full study is here -https://sci.bban.top/pdf/10.1007/s10508-016-0923-z.pdf?download=true.
They use lutocyclin, they claim it’s a bio-identical progesterone, I’m not sure that’s the case, I can’t find much on it,the Big pharma PR agency Wikipedia has 2 pages now for progesterone, the one linked below is titled ‘progesterone medication" ,it has a link to the page about progesterones function as a natural hormone, I’m not sure why they need 2 but my guess is it boosts sales and keeps people from discovering the difference between the artificial and bio identical.
It mentions lutocyclin on the progesterone medications page.

Progesterone (medication) - Wikipedia

en.wikipedia.org

The study also mentions complications in the pregnancy or complications with previous pregnancies hence the use of "progesterone", the stress cycle was present prior to the use of "progesterone". Would be interesting to find out what lutocyclin actually is.

"Lutocyclin is identified as progesterone (bioidentical pro- gesterone)in the Danish Physician’s Desk Reference (Junager & Schleisner, 1963) and was admin- istered during pregnancy to treat cases of potential miscarriage as indicated by staining or bleeding, abortion imminens (threatened abortion), or maternal history of repeated miscarriage. Mean age of the participants at the time of assessment for this study was 23.2 years

 

[boris]

@Drareg It's a weird sentence, they are basically just saying that the Danish PDR refers to it as progesterone. Could be a mistake in the PDR or a deliberate lie.

The Physicians' Desk Reference. Problems and possible improvements - PubMed

The Physicians' Desk Reference (PDR) is a widely used source of drug information by American physicians and patients, but as we shall discuss, it suffers from numerous shortcomings. The PDR is a collection of written and pictorial information that is provided and paid for by pharmaceutical...

pubmed.ncbi.nlm.nih.gov

The Physicians' Desk Reference (PDR) is a widely used source of drug information by American physicians and patients, but as we shall discuss, it suffers from numerous shortcomings. The PDR is a collection of written and pictorial information that is provided and paid for by pharmaceutical manufacturers. The written material for a given drug is a compilation of data and recommendations that are identical to those in the drug's package insert. The wording and directives that are included in these package inserts (and thus in the PDR) represent information that the pharmaceutical companies are permitted to present following discussion and approval by the Food and Drug Administration (FDA), Rockville, Md. The PDR is thus a negotiated effort of commercial enterprises and governmental regulators.

Lutocyclin is in fact a synthetic progestin (see Nebula's link on Ethisterone)

 

[boris]

Pharmaceutical Manufacturing Encyclopedia, 3rd Edition

This industry standard encyclopedia on pharmaceutical manufacturing processes has been completely updated to include FDA drugs approved up to the summer of 2004. The encyclopedia gives details for the manufacture of 2226 pharmaceuticals that are being marketed as a trade-named product somewhere...

books.google.de

 

[Drareg]

@Drareg It's a weird sentence, they are basically just saying that the Danish PDR refers to it as progesterone. Could be a mistake in the PDR or a deliberate lie.

The Physicians' Desk Reference. Problems and possible improvements - PubMed

The Physicians' Desk Reference (PDR) is a widely used source of drug information by American physicians and patients, but as we shall discuss, it suffers from numerous shortcomings. The PDR is a collection of written and pictorial information that is provided and paid for by pharmaceutical...

pubmed.ncbi.nlm.nih.gov

The Physicians' Desk Reference (PDR) is a widely used source of drug information by American physicians and patients, but as we shall discuss, it suffers from numerous shortcomings. The PDR is a collection of written and pictorial information that is provided and paid for by pharmaceutical manufacturers. The written material for a given drug is a compilation of data and recommendations that are identical to those in the drug's package insert. The wording and directives that are included in these package inserts (and thus in the PDR) represent information that the pharmaceutical companies are permitted to present following discussion and approval by the Food and Drug Administration (FDA), Rockville, Md. The PDR is thus a negotiated effort of commercial enterprises and governmental regulators.

Lutocyclin is in fact a synthetic progestin (see Nebula's link on Ethisterone)

Amazing, this explains Wikipedia‘s propaganda page for "progesterone medication", can’t be loosing profits by encouraging the natural route, I’m sure the medical establishment have this tied up legislatively just in case.

 

[Drareg]

Pharmaceutical Manufacturing Encyclopedia, 3rd Edition

This industry standard encyclopedia on pharmaceutical manufacturing processes has been completely updated to include FDA drugs approved up to the summer of 2004. The encyclopedia gives details for the manufacture of 2226 pharmaceuticals that are being marketed as a trade-named product somewhere...

books.google.de

View attachment 21495

BLACK BOX WARNING -SIDE EFFECTS TO INCLUDE ”MAKING YOUR CHILD GAY”.

The wokists will see this as a positive and may want a gay child as it’s trendy these days. Social outrage ensues with questions such as, should being gay be considered a side effect?

 

[gaze]

So I assume progestin use isn't that common during pregnancy, unless there is a possible miscarriage scenario? if the progestin is proven to work to prevent miscarriges in some scenerio, it probably has at least some beneficial effects that bio identical progesterone has. Of course the millions of people on the birth control estrogen and progestin leading up to the pregnancy certainly aren't doing themselves any favors health wise. Hopefully doctors don't start recommending progestin to all women as a "precautionary" motive, but I wouldn't really be surprised if the medical protocol ends up with that. Its a multi billion dollar industry. IF they were to use non synthetic pure progesterone however, a bunch of big head babies would be born according to ray. I wouldn't be surprised if like @Mauritio mentioned that high progesterone kids may be more "curious" and open sexually. I think more research would need to be done on it although reserach like that probably wont happen, im even surpised that study I posted was done.