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Pentoxifylline-tocopherol-clodronate Combination: A Novel Treatment For Osteoradionecrosis Of The Te

paymanz

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Pentoxifylline-tocopherol-clodronate combination: A novel treatment for osteoradionecrosis of the temporal bone. - PubMed - NCBI

Abstract
BACKGROUND:

Osteoradionecrosis (ORN) of the temporal bone is a complication of radiation therapy that is extremely challenging to manage.
METHODS:

We report the case of a patient treated at our institution and present a review of the literature.
RESULTS:

A 52-year-old woman presented with ORN of the temporal bone 20 years after radiation therapy for an ipsilateral parotid tumor. She failed conservative management, including serial debridements, oral and topical antibiotics/antifungals, and aural lavage. As an alternative to hyperbaric oxygen (HBO) and/or temporal bone resection, treatment with pentoxifylline-tocopherol-clodronate combination (PENTOCLO) was pursued and her condition improved dramatically.
CONCLUSION:

This is the first document use of PENTOCLO to treat ORN of the temporal bone. PENTOCLO may represent an effective nonsurgical management option for ORN of the temporal bone. © 2015 Wiley Periodicals, Inc. Head Neck 37: E191-E193, 2015.
 

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