Drareg
Member
- Joined
- Feb 18, 2016
- Messages
- 4,772
This is an interesting study and is being will,be used in lawsuits against finasteride if not now but soon,it will add weight to an overall argument.
The corpus cavernosum is hugely important to penis size,any reduction in this will actually reduce penis size guaranteed.(the corpora cavernosa which contain most of the blood in the penis during an erection)
This study on rats highlights a profound reduction in the size of penis after oral finasteride.
RESULTS:
Serum T and DHT and intraprostatic DHT concentrations, erectile function, and mean weights of the corpus cavernosum and prostate were lowest in group 2. There was no significant difference in the serum T concentration and erectile function between groups 4 and 1. However, the serum and intraprostatic DHT concentrations were significantly lower in group 4 than in group 1 (both P < 0.001). The tissue weights of the corpus cavernosum and prostate were reduced by 25.9% and 92.3% in group 4 compared with group 1 (both P < 0.001). Histopathology revealed a significant atrophy of the prostate in groups 2 and 4. There was a significant decrease in the smooth muscle content in group 2, but not in groups 3 and 4.
CONCLUSIONS:
In a rat model, finasteride treatment for 4 weeks reduces the weight of the corpus cavernosum but appears not to affect the erectile responses to electrical stimulation of the cavernous nerve. As erection is a complex process involving important signaling in the brain, further studies are necessary to demonstrate the long-term effects of finasteride on both central and peripheral neural pathways of erection.
Effects of oral finasteride on erectile function in a rat model. - PubMed - NCBI
The corpus cavernosum is hugely important to penis size,any reduction in this will actually reduce penis size guaranteed.(the corpora cavernosa which contain most of the blood in the penis during an erection)
This study on rats highlights a profound reduction in the size of penis after oral finasteride.
RESULTS:
Serum T and DHT and intraprostatic DHT concentrations, erectile function, and mean weights of the corpus cavernosum and prostate were lowest in group 2. There was no significant difference in the serum T concentration and erectile function between groups 4 and 1. However, the serum and intraprostatic DHT concentrations were significantly lower in group 4 than in group 1 (both P < 0.001). The tissue weights of the corpus cavernosum and prostate were reduced by 25.9% and 92.3% in group 4 compared with group 1 (both P < 0.001). Histopathology revealed a significant atrophy of the prostate in groups 2 and 4. There was a significant decrease in the smooth muscle content in group 2, but not in groups 3 and 4.
CONCLUSIONS:
In a rat model, finasteride treatment for 4 weeks reduces the weight of the corpus cavernosum but appears not to affect the erectile responses to electrical stimulation of the cavernous nerve. As erection is a complex process involving important signaling in the brain, further studies are necessary to demonstrate the long-term effects of finasteride on both central and peripheral neural pathways of erection.
Effects of oral finasteride on erectile function in a rat model. - PubMed - NCBI