• THANKSGIVING SALE: 15% Off @ LifeGivingStore.com & SuchLabs.com Till November 28th With Coupon Code: THANKS2022
    Click Here For Lifegivingstore.com
    Click Here For SuchLabs.com
  • Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.

Passive inhaled mRNA vaccination for SARS-Cov-2

Jam

Member
Joined
Aug 10, 2018
Messages
1,884
Age
50
Location
Piedmont

Dear Editor,

The world is currently facing an unprecedented outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the Coronavirus Disease 2019 (COVID-19) in humans. At the time of writing, more than 38 million persons have been infected with the virus, with more than a million recorded COVID-related deaths [1]. Scientists are urgently trying to develop a safe and efficacious vaccine for SARS-CoV-2, which must also be produced in large quantities to protect vulnerable populations against SARS-CoV-2.

To achieve this, we propose the massive and passive immunization of the at-risk population via cohorting with individuals who have recently contracted SARS-CoV-2, but are deemed non-infectious albeit reverse transcription-polymerase chain reaction (RT-PCR)-positive. Testing RT-PCR positive would imply the continued spread of non-viable mRNA particles into the surroundings [2].

Multiple studies have noted that individuals who has had SARS-CoV-2 for more than 10 days were non-infectious, though they remained RT-PCR-positive [3], [4]. The above finding is in line with current US Centers for Disease Control and Prevention (CDC) guidance that “persons with mild to moderate COVID-19 remain infectious no longer than 10 days after symptom onset” and persons with “more severe to critical illness or severe immunocompromise likely remain infectious no longer than 20 days after symptom onset” [5].

Messenger RNA (mRNA) as a means for passive immunization has been extensively studied for years. Early studies since the 1990s showed that exogenous mRNA could direct protein expression in vivo, cementing mRNA as a promising drug platform technology [6], [7]. Several studies later demonstrated the utility of mRNA in vaccine development and conferring protection against cancers [8] and infectious diseases [9], [10]. Moreover, passive mRNA immunization also experiences fewer safety issues due to its non‐integrative and transient nature [11], the latter of which contributes to better and/or easier control of protein expression.

The potential role of mRNA vaccination in the fight against SARS-CoV-2 is evidenced by ongoing COVID-19 Phase I vaccine trials conducted by several pharmaceutical companies, including Moderna Therapeutics’ mRNA-1273 vaccine [12], [13], which has yielding promising results. The feasibility of inhaled RNA for passive transfection has also been proven in a number of studies [14]. On a mechanistic level, the inhaled RNA may lead to passive synthesis of non-infectious spike proteins using cell transfection machinery, hence leading to immunization of the individual.

Though there are no conclusive or ongoing large scale clinical studies yet to prove the above hypothesis, we believe this proposal is worth exploring in our battle against COVID-19, given the significant number of already recovered individuals and the natural shedding of nonviable SARS-CoV-2 particles in the environment.
 

JudiBlueHen

Member
Joined
Jun 26, 2017
Messages
446
On a mechanistic level, the inhaled RNA may lead to passive synthesis of non-infectious spike proteins using cell transfection machinery,
Oh good grief please spare me from this insanity! This is how they will get it into younger children...
 

fico

Member
Joined
Aug 13, 2020
Messages
447
There were lots of problems in trying to keep the vaccines at very low temperatures.

In addition to contamination, they lost a lot of their product because of refrigeration issues.

Back to la-la land, if an airborne product is achieved, the elite can join us in getting some, too.

If it is something a la epicyte gene that's keeping you awake, watch what you eat.
 

Similar threads

Top