OP
- Joined
- Apr 5, 2016
- Messages
- 1,655
Hi been a long time since I posted so I thought I would give an update to anyone who is interested.
So unfortunately she has historically not been very good at following my supplement recommendations for a long period of time. She flat out refused or would take them only when I was there to give them to her. This is understandable as she is very worried that things will make her symptoms worse and this has happened a few times as she is very sensitive to anything that increases serotonin.
About 6 months ago she went to a neurological doctor who put her on rotigotine which is a dopamine agonist, however it has one side effect which I knew was going to be devastating that is it is a 5-ht1 (serotonin) agonist. When she started on rotigotine she had some initial improvements but it would always start with her being very shaky, nervous and uncomfortable for 4-5 hours and afterwards she would be a lot calmer. So it appears when the serotonin increase died down she would get the positive effects of the dopamine.
However as the months went on the symptoms from the increase in serotonin became worse and worse to the point where it was unbearable. She could not sit still for more than 5 minutes, was constantly sweating with hot flashes, this made her very sad and depressed. The only thing that seemed to give her some relief was when I gave her topically cyproheptadine but it was not enough.
Finally a few weeks ago I got her to stop the patches altogether and gave her ORALLY 4mg of cyproheptadine and topically 100mcg of Lisuride. This was a GAME CHANGER! She instantly had an improvement like flipping a switch. She also started at the same time on a new diet that eliminates any PUFAs (something i've been trying to get her to do forever) also eliminating processed foods and grains that could irritate the gut which is where most serotonin is produced.
I think taking cyproheptadine orally has been MUCH more effective then topically for her, this really has been transformative, she is much calmer, can sleep easier, is much less anxious and her hot flashes and sweats which were almost constant have virtually gone. She also had a very bad back which has greatly improved, i've long suspected the bad back is in large part due to Parkinson's possibly with a connection to high gut serotonin and endotoxin and the oral cypro and change in diet is helping to combat that.
Her current regime is Cyproheptadine in doses of 3-4 mg three times per day and 100mcg of lisuride twice per day.
My next plan is to give her low doses of pregnenolone starting at 10mg and slowly build up. The reason for this is the multifaceted and obviously there is a lot of research on it for its neuroprotective effects but there are studies posted by @haidut that show it being beneficial for back problems.
I have also purchased some Quinine which I will eventually try for its anti-serotonin properties as I believe this may offer other benefits that Cypro does not.
So unfortunately she has historically not been very good at following my supplement recommendations for a long period of time. She flat out refused or would take them only when I was there to give them to her. This is understandable as she is very worried that things will make her symptoms worse and this has happened a few times as she is very sensitive to anything that increases serotonin.
About 6 months ago she went to a neurological doctor who put her on rotigotine which is a dopamine agonist, however it has one side effect which I knew was going to be devastating that is it is a 5-ht1 (serotonin) agonist. When she started on rotigotine she had some initial improvements but it would always start with her being very shaky, nervous and uncomfortable for 4-5 hours and afterwards she would be a lot calmer. So it appears when the serotonin increase died down she would get the positive effects of the dopamine.
However as the months went on the symptoms from the increase in serotonin became worse and worse to the point where it was unbearable. She could not sit still for more than 5 minutes, was constantly sweating with hot flashes, this made her very sad and depressed. The only thing that seemed to give her some relief was when I gave her topically cyproheptadine but it was not enough.
Finally a few weeks ago I got her to stop the patches altogether and gave her ORALLY 4mg of cyproheptadine and topically 100mcg of Lisuride. This was a GAME CHANGER! She instantly had an improvement like flipping a switch. She also started at the same time on a new diet that eliminates any PUFAs (something i've been trying to get her to do forever) also eliminating processed foods and grains that could irritate the gut which is where most serotonin is produced.
I think taking cyproheptadine orally has been MUCH more effective then topically for her, this really has been transformative, she is much calmer, can sleep easier, is much less anxious and her hot flashes and sweats which were almost constant have virtually gone. She also had a very bad back which has greatly improved, i've long suspected the bad back is in large part due to Parkinson's possibly with a connection to high gut serotonin and endotoxin and the oral cypro and change in diet is helping to combat that.
Her current regime is Cyproheptadine in doses of 3-4 mg three times per day and 100mcg of lisuride twice per day.
My next plan is to give her low doses of pregnenolone starting at 10mg and slowly build up. The reason for this is the multifaceted and obviously there is a lot of research on it for its neuroprotective effects but there are studies posted by @haidut that show it being beneficial for back problems.
I have also purchased some Quinine which I will eventually try for its anti-serotonin properties as I believe this may offer other benefits that Cypro does not.
