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Another thing to keep in mind is that the group of mice with sterile guts was fully immune to developing Parkinson. So much for sterile gut being bad for us and thus the need to supplement expensive probiotics.
Given the recent study about Alzheimer being possible caused by endotoxin, I suspect it is the serotonin/endotoxin/NO trio responsible for Parkinson.
Endotoxin (LPS) May Be A Causative Factor In Alzheimer Disease (AD)
The role of NO in Parkinson is well established, but the other two would be harder for mainstream medicine to accept.
The Nitric Oxide (NO) Theory Of Aging
Aside from the antibiotics, TLR4 antagonists and serotonin antagonists would obviously help for PD if it is indeed of gut origin. Also, vitamin K2 (MK-4) has been shown to reverse the pathology in an animal model, and thiamine recently made the news as having success in a human trial. Incidentally, thiamine was recently found to prevent septic shock and death from endotoxemia in humans. So, the success of thiamine in PD may be due to endotoxin blocking in addition to its effects on raising CO2 and stimulating PDH.
Vitamin K2 Is A Mitochondrial Electron Carrier That Rescues Pink1 Deficiency
Thiamine (B1) Reverses Parkinson Disease In Humans
Agree 100% with this assessment. I'm in the process of writing another paper on PD with a focus on serotonin. I don't believe that it is necessarily the single causative factor, but I believe that by keeping it focused on this one aspect my mothers doctors who I am presenting to, will be more open to the idea of using serotonin antagonists as a viable treatment option.
With regards to Thiamine I found an interesting study that showed that thiamine deficiency increased serotonin synthesis and impeded the expulsion of serotonin from the brain which might explain partially why supplementation with Thiamine has the beneficial effect on PD.
Effect of thiamine deficiency on brain serotonin turnover.
"These results suggest that acute thiamine deficiency, induced by PT, both increases brain 5-HT synthesis and impairs 5-HIAA efflux from the brain. There is a close correlation between neurological manifestations and changes in brain 5-HT metabolism in acute thiamine deficiency."
Oh wow, this is a great study! Thanks so much for sharing. I always wondered why thiamine seemed to have such calming and pro-metabolic effects and this seems to answer it.
Another thing to keep in mind is that the group of mice with sterile guts was protected from developing Parkinson. So much for sterile gut being bad for us and thus the need to supplement expensive probiotics.
Given the recent study about Alzheimer being possible caused by endotoxin, I suspect it is the serotonin/endotoxin/NO trio responsible for Parkinson.
Endotoxin (LPS) May Be A Causative Factor In Alzheimer Disease (AD)
The role of NO in Parkinson is well established, but the other two would be harder for mainstream medicine to accept.
The Nitric Oxide (NO) Theory Of Aging
Aside from the antibiotics, TLR4 antagonists and serotonin antagonists would obviously help for PD if it is indeed of gut origin. Also, vitamin K2 (MK-4) has been shown to reverse the pathology in an animal model, and thiamine recently made the news as having success in a human trial. Incidentally, thiamine was recently found to prevent septic shock and death from endotoxemia in humans. So, the success of thiamine in PD may be due to endotoxin blocking in addition to its effects on raising CO2 and stimulating PDH.
Vitamin K2 Is A Mitochondrial Electron Carrier That Rescues Pink1 Deficiency
Thiamine (B1) Reverses Parkinson Disease In Humans
Oh wow, this is a great study! Thanks so much for sharing. I always wondered why thiamine seemed to have such calming and pro-metabolic effects and this seems to answer it.
Another thing to keep in mind is that the group of mice with sterile guts was protected from developing Parkinson. So much for sterile gut being bad for us and thus the need to supplement expensive probiotics.
Given the recent study about Alzheimer being possible caused by endotoxin, I suspect it is the serotonin/endotoxin/NO trio responsible for Parkinson.
Endotoxin (LPS) May Be A Causative Factor In Alzheimer Disease (AD)
The role of NO in Parkinson is well established, but the other two would be harder for mainstream medicine to accept.
The Nitric Oxide (NO) Theory Of Aging
Aside from the antibiotics, TLR4 antagonists and serotonin antagonists would obviously help for PD if it is indeed of gut origin. Also, vitamin K2 (MK-4) has been shown to reverse the pathology in an animal model, and thiamine recently made the news as having success in a human trial. Incidentally, thiamine was recently found to prevent septic shock and death from endotoxemia in humans. So, the success of thiamine in PD may be due to endotoxin blocking in addition to its effects on raising CO2 and stimulating PDH.
Vitamin K2 Is A Mitochondrial Electron Carrier That Rescues Pink1 Deficiency
Thiamine (B1) Reverses Parkinson Disease In Humans
@haidut a friend of mines 17 year old daughter was diagnosed with PNKD..... PNKD is somehow related to PD and epilepsy... can you shed some light on this illness and a a Peat plan of action for this young lady?
PNKD is the abbreviation for a human neurological movement disorder paroxysmal nonkinesiogenic dyskinesia.
yes... again thank u haidut.I answered your PM. The choreic disorders are usually connected to high estrogen and cortisol, which is supported by the exacerbations of PNKD symptoms around ovulation.