Pansterone - Liquid Dietary Supplement For Rejuvenation

Discussion in 'IdeaLabs' started by haidut, Aug 4, 2015.

  1. jag2594

    jag2594 Member

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    Can you go into further detail regarding the possibility of raising aldosterone by taking pregnenolone and DHEA ? Pregnenolone increases progesterone, and progesterone has anti-aldosterone effects. The only reason I see aldosterone rising is if you take too much DHEA or take it within the wrong hormonal context due to estrogen.
     
  2. OP
    haidut

    haidut Member

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    This is explained in the original post of the thread. DHEA inhibits 17a-hydroxylase so it reduces the conversion of pregnenolone into DHEA and also of progesterone into the androgenic steroids. DHEA also inhibits 11b-HSD1 but enhances 11b-HSD2, so this will lower cortisol but (potentially) increase corticosterone, and thus (potentially) increase aldosterone. In other words, taking high doses DHEA or DHEA with high doses of pregnenolone may increase aldosterone for some people and thus blood pressure. How often it happens I am not sure.
     
  3. Entropy

    Entropy Member

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    Will this yield much progesterone, or should I get progesterone as well?
     
  4. emmanceb

    emmanceb Member

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    Also wondering about the equivalence of progesterone per dose if possible, an approximation :hattip
     
  5. Milky

    Milky Member

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    Does anyone have any updates/testimonials to share for this one yet? Mine arrives tomorrow.
     
  6. Such_Saturation

    Such_Saturation Member

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    What is the concentration of DMSO?
     
  7. supercoolguy

    supercoolguy Member

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    I use around 300mg in Coco Oil once per week. Didnt RP used to shovel-in around 3000mg/day? For about a year. Based on Rat Studies that showed no side effects at a 10gm dose. = about 1lb for human. (Im sure adding DHEA & DMSO would change the effect) :2cents
     
  8. bailadora

    bailadora Member

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    I've been using it for a little over a week. I started 8 drops day for a couple days on wrist and then ramped up over the past 3 days to 8 drops twice a day usually around mealtime on backs of hands. I don't know if I need to go thrice/day. I think I like this dose for now. I may get a wild hair. On the weekend and try 3xs/day just to see what happens.
    I have to rotate locations every few days- it starts to tingle/irritate skin. Otherwise there is an initial alcoholly smell that dissipates within a couple minutes.
    I feel really calm for a few hours. But energized. I am under a lot of stress with a huge project at work and so far I believe it's helping me cope well or better than I normally would. I feel as if It is helping me Communicate verbally.
    Some of this may be placebo and of course this is my experience but I am pleased so far.
    I started a weight training program last week also so I am hoping for muscle gain.
    I am in my late 40s and have been on a hormonal roller coaster since my teens although I didn't really know that until I started reading peat. I was using protest e during luteal but stopped 3 weeks ago to start this.
    My temps have usually been good-waking 97.7 and up and this has continued. Mostly wake with low 98s.
    One remarkable thing that happened yesterday was after my late in the day dance class ( very physically demanding requiring a lot of stamina) I was able to shower and drop right off to sleep. Normally I would NOT be able to drop off. I would be so wound up sleep would be short and not good quality. This is a very good thing for me.
     
  9. OP
    haidut

    haidut Member

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    Yes, it should increase progesterone but there is no guarantee. In some people it will just elevate pregnenolone and it will stay as pregnenolone and its metabolite pregnenolone sulfate. That's why some people need to supplement pure progesterone - i.e. they don't convert pregnenolone that well. But with Pansterone even those people should get a boost in progesterone. Also, in some women pregnenolone has androgenic effects, so these people also need a pure progesterone supplement. I just wanted to cover all bases.
     
  10. OP
    haidut

    haidut Member

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    What do you mean by equivalence of progesterone? This supplement does not have progesterone in it but you end up metabolizing some of it into progesterone. The Progestene supplement has pure progesterone (USP) and it is close to 100% bioavailable. So, taking a full dose of Progestene gives you about 20mg progesterone in the blood, which is how much young women produce daily in the luteal phase.
     
  11. OP
    haidut

    haidut Member

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    It is 80% DMSO and 20% ethanol. No other excipients. Studies show optimal hormone absorption when steroids are dissolved in at least 70% DMSO.
     
  12. OP
    haidut

    haidut Member

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    When applied to sore muscles Pansterone will help them recover more quickly. When applied to head parts like temples, forehead, neck, ears, etc Pansterone acts like a nootropic.
     
  13. Brian

    Brian Member

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    Which would you expect to be most beneficial to a post-menopausal woman with a lowered metabolism? (Pansterone or Progestene)
     
  14. OP
    haidut

    haidut Member

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    I would go with Pansterone since both pregnenolone and DHEA have strong pro-metabolic properties, and the person should also get an increase in progesterone from using Pansterone. I think Progestene is reserved for people with strong estrogen dominance, fibrotic conditions of the breasts / uterus / vagina, seizures, osteoporosis, etc. Of course, all of these conditions should be discussed with a doctor prior to taking the supplements.
     
  15. Such_Saturation

    Such_Saturation Member

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  16. OP
    haidut

    haidut Member

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    Unlikely, since if you take the full daily dose of 24 drops this means no more than ~750mg DMSO daily. Most studies that found systemic side effects used several grams per day, sometimes administered IV. But it can cause skin irritation is applied to the same skin spot several days in a row.
     
  17. tara

    tara Moderator

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    My understanding of DMSO is that it can increase the potency of some other chemicals - eg other medicines one is using, and potentially increase the absorption of other substances in contact with the skin (eg make-up, cleaning products, industrial chemicals).

    I don't know about how high the DMSO dose has to be to make an appreciable difference in this for different substances. But if the dose in this product affects absorption of it's ingredients, I don't see why it wouldn't also affect other substances present too.

    That doesn't mean I don't think people should use it, just that I recommend being thoughtful about whether this is OK with respect to other supplements or exposures, and at least monitor this so you can adjust other things if needed.
     
  18. Entropy

    Entropy Member

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    Thanks for the reply,

    I have to confirm with more testing but it seems twice now applying pansterone eyebrow area/forehead helps clear sinus congestion.
     
  19. OP
    haidut

    haidut Member

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    Excellent! This effect is to be expected if the congestion is caused by inflammation of the sinus cavities. I think there was/is a medical product on the market for sinusitis that delivers intranasal pregnenolone.
     
  20. Milky

    Milky Member

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    Received my bottle yesterday. Does it need to be refrigerated or is room temperature fine?
     
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