Out of control Aromatase, can take 4 arimidex in a day

[Diddleum]

Had health issues along time, I have some other thread if interested. Im 39 and ive had the same issues my whole adult life.

I discovered much by chance that estrogen is playing a big part in how I feel, by taking arimidex.

At the start just 0.25mg would give me a hour or two of feeling good.
I then got onto 1mg a day and for a while I felt pretty good.
At one point I was up to 4mg a day (YES IT WAS A PHARMA QUALITY)

I started getting joint and bone ache and results from where hard to get. Hard to find a sweet spot. It felt like the body was always varying its aromatase and fghting against my attempts to inhibit it.

Recently I took 5mg of pharma Letrosole as I felt so anxious and I had to go to a party, after 5 hours the anxiety started to subside. But the next day or so, the joint and bone ache came on.

I bought pfizer exemestane and they dont seem to do anything, 50mg feels like a sweet.

Without aromatase control, im anxious, lethargic, depressed. The sweet spot feels so good, like I imagine life should be,

Ive tried all the normal peat aromatase inhibitors, but they dont do anything.... Thyroid, Progesterone, White mushrooms, carrots, androsterone, diet, asprin, vitamin e, a etc etc.

Diet wise, if I Starve myself I can feel awesome for a day or two, I assume because my estrogen has dropped as I starve.... Occasionally When I start eating again or go from a period of low carb to high carb I can feel awesome for a period of time before Aromatase and estrogen take over.

Ive tried TRT, I got my T up to 5 times normal and I Felt the exact same really.

Im currently playing around with Turinabol to completely replace my T (so theres little substrate for aromatase to convert to Estrogen) and Masteron (To ensure I get something like DHT and for its Anti-E properties.

Im at a complete loss, feels impossible to be able to find a steady dosing pattern with the Aromatase Inhibitors, and takig such high doses cant be healthy.

Can anyone give me any crazy ideas how I can control my mad crazy Aromatase/Estrogen that even pharma AI's are struggling to deal with?

 

[Hans]

Do you have digestive problems? Perhaps GERD, bloating, excess flatulence, loose stool or slightly constipated? Gut issues can result in those symptoms and also increase aromatase.

 

[Andman]

5mg letro and you felt fine? thats crazy

do you have excess body fat to lose? can really help with estrogen control from personal experience

also, hows your liver?

 

[CloudsInTheHead]

Do you have blood tests?

 

[Diddleum]

Do you have digestive problems? Perhaps GERD, bloating, excess flatulence, loose stool or slightly constipated? Gut issues can result in those symptoms and also increase aromatase.

Hello, No digestive problems really, I guess you could say mildly constipated, I go most days but not every day. But many people would say thats normal I guess.

When taking the Arimidex I could feel my test increasing to compensate, my balls swelled I got greasy hair and skin. This I understand as my body trying to keep its desired level of estrogen by all means possible. Even when my T is really high from TRT and my balls have shrunk, when I Start taking Arimidex my balls seem to fire up again restoring the size like you would expect PCT would do.

It feels like my HPA axis is based upon my estrogen levels and not my testosterone levels. It wants to keep a certain level of Estrogen.

My next experiment it to try mild trenbolone to see what its progesterone increasing effects feel like. Maybe itll counter my Estrogen?

I know that none of these are healthy, but I havent really been living most of my life, and considered suicide. Doctors cant do anything but prescribe a anti depressant. The risk reward is worth it for me.

 

[Diddleum]

5mg letro and you felt fine? thats crazy

do you have excess body fat to lose? can really help with estrogen control from personal experience

also, hows your liver?

Yup, I Can pop them like sweets, and it takes a while for the joint pain to creep in, nothing major, just a slow progression before I realise I have to stop.

They are all pharma quality. Got pfizer aromasin here and feels like they do nothing.

Liver is fine as far as I can tell, liver blood tests are always good. I dont drink, have always eaten well. Go to the toilet on average once a day.

No body fat to loose, I cam ripped! I have never had an ounce of fat on me, at an age of 39, and without exercising much you Im 180lb, 6ft and you can see 8/10 of my abs. I look like a body builder.

 

[Diddleum]

Do you have blood tests?

I have loads of blood tests.

Super high SHBG, 100 before TRT.... Most people say exogenus test lowers SHBG but it increased mine to 125. I think in my case the SHBG is protective over the high levels of aromatization. Test is normal amount, but because of SHBG my free test is in the gutter. Pushing my free test into normal range with TRT didnt seem to make any sympto improvements.... Assuming because my Estrogen was to high.

Prolactin is on the high end of normal .

Other than that, there is nothing remarkable about my bloods. Estrogen is a insensitive test but always in range.

 

[Diddleum]

Have been experimenting with Masteron, 200mg per week. It seems to have improved my erection somewhat, but ive got poor libido. ITs hard to get turned on, but once the blood starts going there from alot of manual stimulation, it does seem to hang about a bit longer. Viagra works a bit better and im able to have a normalish sex life with my girlfriend at the minute which is a massive relief. Seem to be struggling to orgasm, which doesnt bother me as I have no libido, but bothers her somewhat.

Got proviron coming, its meant to have similar effect to masteron but better libido and mood.

If have been experimenting with pt-141 and it definately works. If anyone has issues with erections then pt-141 is now FDA approved for women, and works for men as well. It takes a while to get your dose and timing right but it works with less sides than viagra for me.

 

[Diddleum]

Do you have digestive problems? Perhaps GERD, bloating, excess flatulence, loose stool or slightly constipated? Gut issues can result in those symptoms and also increase aromatase.

I did read an article of yours on estrogen on reddit, it was really informative - thankyou. High carbs, blood sugar swings definately makes my symptoms worse. You mentioned insulin can affect aromatase and I have felt a bit better since spreading my carbs out little and often and always with protein/fat. So thankyou Hans, you prompted a positive change in me.

The typical Ray Peat diet followed on here with orange juice, sugar, caffiene, is literally the worst diet for me. LIttle and often eating, seems to be the best I can do for my symptoms but still no cure.

I have taken SSRIs over 15 years ago, so PSSD is possible.

 

[S-VV]

It feels like my HPA axis is based upon my estrogen levels and not my testosterone levels. It wants to keep a certain level of Estrogen.

Lol, thats because it is! Thats why SERMs are used in PCT

 

[Diddleum]

Lol, thats because it is! Thats why SERMs are used in PCT

Yeah, Im starting to see that the majority of information on the web saying that HPA is focusing mostly on Test levels is complete nonsense.

That SERMS work proves it to an extent, but do you think the HPA only looks at estrogen levels or both, variations in inviduals?

Is the HPA set point for estrogen fixed?

Ive never read anything about changing the set point itself. Im wondering if the pro progesterone effects of trenbolone might be able to influence that set point? It makes sense as guys get extremely dry and ripped on trenbolone desptite taking 400-1000mg of test, without the trenbolone im sure they would balloon up with water. So im going to experiement with low dose Tren next. Might give me some hints.

This is all just guess work from someone with no medical background, as im sure youve guessed. lol.

 

[Michael Mohn]

Once a day a dump, maybe? I eat mostly fruits as carbs and I go like 5 times a day. I think your digestion has a problem. Have you tried thyroid before?

PS. Ok you took thyroid, missed it.

 

[Michael Mohn]

If you have short term improvement with fasting you might have high endotoxin, infection, high inflamation which can antagonize androgens. How do you feel about taking antibiotics?

 

[Hans]

I did read an article of yours on estrogen on reddit, it was really informative - thankyou. High carbs, blood sugar swings definately makes my symptoms worse. You mentioned insulin can affect aromatase and I have felt a bit better since spreading my carbs out little and often and always with protein/fat. So thankyou Hans, you prompted a positive change in me.

The typical Ray Peat diet followed on here with orange juice, sugar, caffiene, is literally the worst diet for me. LIttle and often eating, seems to be the best I can do for my symptoms but still no cure.

I have taken SSRIs over 15 years ago, so PSSD is possible.

Awesome man, glad it was helpful!

 

[Diddleum]

If you have short term improvement with fasting you might have high endotoxin, infection, high inflamation which can antagonize androgens. How do you feel about taking antibiotics?

I do tend to relate times when I feel a bit better when im more regular on the toilet.

Have tried taking Tetracycline for a while after reading on here, but too no affect....

 

[Michael Mohn]

I do tend to relate times when I feel a bit better when im more regular on the toilet.

Have tried taking Tetracycline for a while after reading on here, but too no affect....

Penicillin based antibiotics are much more powerful than tetracyclines.

 

[Diddleum]

Penicillin based antibiotics are much more powerful than tetracyclines.

Ok, I will try another one then. Thanks.

 

[S-VV]

Yeah, Im starting to see that the majority of information on the web saying that HPA is focusing mostly on Test levels is complete nonsense.

That SERMS work proves it to an extent, but do you think the HPA only looks at estrogen levels or both, variations in inviduals?

Is the HPA set point for estrogen fixed?

Ive never read anything about changing the set point itself. Im wondering if the pro progesterone effects of trenbolone might be able to influence that set point? It makes sense as guys get extremely dry and ripped on trenbolone desptite taking 400-1000mg of test, without the trenbolone im sure they would balloon up with water. So im going to experiement with low dose Tren next. Might give me some hints.

This is all just guess work from someone with no medical background, as im sure youve guessed. lol.

Although both T and E have local negative feedback on the whole HPG axis, the major control is the hypothalamus, and that responds more strongly to estrogens. The E setpoint may be fixed in that the hypothalamus is striving to a homeostatic equilibrium, and it will resist changes to altering it. Your case is quite unique, have you measured your serum E2?

 

[Diddleum]

Although both T and E have local negative feedback on the whole HPG axis, the major control is the hypothalamus, and that responds more strongly to estrogens. The E setpoint may be fixed in that the hypothalamus is striving to a homeostatic equilibrium, and it will resist changes to altering it. Your case is quite unique, have you measured your serum E2?

I have, but in the UK there are only the insensitive estrogen tests so im unsure how accurate it is. The level from the test is never consistent, sometimes high in range sometimes low.

SHBG is very high (100),went up to 125 whilst on TRT. Prolactin in top of range.

When I drink alcohol, I get three day like hangover, worsening of my everyday symptoms. Im assuming it increases the aromatase activity even greater. Large amount of aromatase inhibitor would give me relief from these hangover symptoms but at the minute I feel somewhat resistant to any amount of letrozole. Since I startedregularly taking AI ive had oneof the best/most consistent periodof my life, but it started to become worse and inconsistent when I titrated up to 4 arimidex in a day to get the relief.

Im reading the HPG axis responds to Testosterone, Estrogen and Progesterone... Progesterone high dose is used as a basis of the novel male contraceptive which really lowers FSH.

Imreally at a loss what to try next, wondered if anyone had any bright ideas I could try.

 

[Hans]

I have, but in the UK there are only the insensitive estrogen tests so im unsure how accurate it is. The level from the test is never consistent, sometimes high in range sometimes low.

SHBG is very high (100),went up to 125 whilst on TRT. Prolactin in top of range.

When I drink alcohol, I get three day like hangover, worsening of my everyday symptoms. Im assuming it increases the aromatase activity even greater. Large amount of aromatase inhibitor would give me relief from these hangover symptoms but at the minute I feel somewhat resistant to any amount of letrozole. Since I startedregularly taking AI ive had oneof the best/most consistent periodof my life, but it started to become worse and inconsistent when I titrated up to 4 arimidex in a day to get the relief.

Im reading the HPG axis responds to Testosterone, Estrogen and Progesterone... Progesterone high dose is used as a basis of the novel male contraceptive which really lowers FSH.

Imreally at a loss what to try next, wondered if anyone had any bright ideas I could try.

Did you have a liver panel done?