Hi,
I was reading about the effectiveness of various 'aromatase inhibitors' - particularly those 'natural' compounds found in supplements derived from extracts of plants (ie. grape fruit extract, curcumin, blueberries, celery, fenugreek, ginger, goji, safflower, etc). In my reading, I have noticed that while some of these supposed aromatase inhibitors mostly do what they say on the box, they also cause steep rises in the production of nitric oxide, which Ray strongly warns against. You can read interesting commentary on studies into these compounds here: http://www.ergo-log.com/antiestrogenic.html
Although grape seed extract is implicated in raising the levels of nitric oxide, its effect on the body contradicts the very types of symptoms that excess nitric-oxide causes - ie. varicose veins, cell death, etc. More info evidencing this here: http://www.ergo-log.com/gse.html
In further reading about the relationship between aromatase inhibition and nitric oxide via pubmed, I found some studies that demonstrated the effectiveness of various nitric oxide-inhibitors. Some of these are: NAC and l-ornithine, among others. I am interested in experimenting with grape fruit extract for its aromatase inhibition factor, but was wondering if l-ornithine would prevent the expected rise in nitric-oxide.
This study says l-ornithine irreversibly prevents nitric oxide production, but I'm not sure what this really means: http://www.ncbi.nlm.nih.gov/pubmed/15656623 and http://www.ncbi.nlm.nih.gov/pubmed/1710525
Anyway, until I know more I'm not taking grape seed extract. I know Ray says caffeine and niacinamide also antagonist nitric oxide production, but I'm not sure how effective or safe this is.
Maybe a question for haidut?
Cheers for the ever-enjoyable forum of chemistry and health discussion.
I was reading about the effectiveness of various 'aromatase inhibitors' - particularly those 'natural' compounds found in supplements derived from extracts of plants (ie. grape fruit extract, curcumin, blueberries, celery, fenugreek, ginger, goji, safflower, etc). In my reading, I have noticed that while some of these supposed aromatase inhibitors mostly do what they say on the box, they also cause steep rises in the production of nitric oxide, which Ray strongly warns against. You can read interesting commentary on studies into these compounds here: http://www.ergo-log.com/antiestrogenic.html
Although grape seed extract is implicated in raising the levels of nitric oxide, its effect on the body contradicts the very types of symptoms that excess nitric-oxide causes - ie. varicose veins, cell death, etc. More info evidencing this here: http://www.ergo-log.com/gse.html
In further reading about the relationship between aromatase inhibition and nitric oxide via pubmed, I found some studies that demonstrated the effectiveness of various nitric oxide-inhibitors. Some of these are: NAC and l-ornithine, among others. I am interested in experimenting with grape fruit extract for its aromatase inhibition factor, but was wondering if l-ornithine would prevent the expected rise in nitric-oxide.
This study says l-ornithine irreversibly prevents nitric oxide production, but I'm not sure what this really means: http://www.ncbi.nlm.nih.gov/pubmed/15656623 and http://www.ncbi.nlm.nih.gov/pubmed/1710525
Anyway, until I know more I'm not taking grape seed extract. I know Ray says caffeine and niacinamide also antagonist nitric oxide production, but I'm not sure how effective or safe this is.
Maybe a question for haidut?
Cheers for the ever-enjoyable forum of chemistry and health discussion.