Original antigenic sin, possible vaccine shedding

[zwez]

It appears people who get vaccinated never develop nucleocapsid antibodies to SARS-CoV-2. The fact that (S) spike protein antibodies do not prevent infection, death or hospitalization and they appear to prevent the development of (N) nucleocapsid antibodies means this disease may never go away for those who are vaccinated.

Original antigenic sin - Wikipedia

en.wikipedia.org

Original antigenic sin, also known as antigenic imprinting or the Hoskins effect,[1] refers to the propensity of the body's immune system to preferentially utilize immunological memory based on a previous infection when a second slightly different version of that foreign pathogen (e.g. a virus or bacterium) is encountered. This leaves the immune system "trapped" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections. Antibodies or T-cells induced during infections with the first variant of the pathogen are subject to a form of original antigenic sin, termed repertoire freeze.

https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1025358/Vaccine-surveillance-report-week-41.pdf

There may also be clues in this report as to vaccine shedding induced spike (S) protein antibodies.

 

[Don]

It appears people who get vaccinated never develop nucleocapsid antibodies to SARS-CoV-2. The fact that (S) spike protein antibodies do not prevent infection, death or hospitalization and they appear to prevent the development of (N) nucleocapsid antibodies means this disease may never go away for those who are vaccinated.

Original antigenic sin - Wikipedia

en.wikipedia.org

https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1025358/Vaccine-surveillance-report-week-41.pdf

There may also be clues in this report as to vaccine shedding induced spike (S) protein antibodies.

what a nightmare thats been pulled over most of the world...............

 

[Lollipop2]

Fascinating about the nucleocapsid antibodies. Thanks for sharing this.

 

[zwez]

This recent study seems to leave the authors perplexed as to why the majority of the vaccinated fail to develop (N) nucleocapsid antibodies.

Serological markers of SARS-CoV-2 infection; anti-nucleocapsid antibody positivity may not be the ideal marker of natural infection in vaccinated individuals

www.ncbi.nlm.nih.gov

Twenty-three participants reported a breakthrough infection post-vaccination, defined as PCR-confirmed SARS-CoV-2 infection ≥14 days after completion of vaccination (5). This represented 0.6% (23/4111) of all fully vaccinated participants in the study. All had received Pfizer vaccine (which was the vaccine received by most study participants). For these 23 participants, the median number of days between second vaccine dose and positive PCR was 30 days (IQR 25–50 days). Five (22%) had symptoms at the time of the positive PCR test and 18 (78%) did not have symptoms (they were tested as close contacts or as part of hospital outbreaks). All 23 participants had detectable anti-S antibodies, as expected post vaccination (6). Notably, only 6/23 (26%, 95%CI: 11–49) had detectable anti-N antibodies in response to their infection, compared to 663/812 (82%, 95%CI: 79–84, p-value= <0.001 (Chi-squared) of all participants in the study with previous PCR-confirmed infection having detectable anti-N antibodies. Of the 17 that were anti-N negative, median number of days between PCR positivity and sampling mid-point was 52 (range 9–67) so it is surprising that the majority of these had not mounted an anti-N antibody response (7). This low number of seroconversions might suggest that anti-N antibodies may be insensitive as a marker of natural infection post vaccination.

 

[aliml]

Original Antigenic Sin and the immune response

Editor's comment - the details described in this news item have been widely reported and links are provided to the sources. Anyone concerned about whether vaccines are appropriate for them should seek advice from their doctor.

www.totalhealth.co.uk

 

[aliml]

UK Health Security Document Indicates That That N Antibody Levels Appear To Be Lower In Fully Vaccinated Individuals Who Acquire Infection!

UK Health Security Document Indicates That That N Antibody Levels Appear To Be Lower In Fully Vaccinated Individuals Who Acquire Infection! - Thailand Medical News

(Note: Before reading this article, with winter fast approaching, and more Delta sub-variants emerging along with other new variants and recombinant strains, we strongly advised that everyone gets vaccinated fast especially since a majority are ignorant and do not have access to other protocols...

www.thailandmedical.news

 

[JohnHafterson]

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